Results 251 to 260 of about 130,425 (315)

Referee report. For: Targeting KRAS mutation in gastrointestinal cancers [version 1; peer review: 2 approved with reservations]

Jing Lu
openalex   +1 more source

Yield of Whole Genome Sequencing for Pathogenic Single Nucleotide Variants in Congenital Heart Disease: A Systematic Review and Meta‐Analysis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to assess the diagnostic yield of pathogenic or likely pathogenic (P/LP) single nucleotide variants (SNVs) using whole genome sequencing (WGS) in congenital heart disease (CHD). Methods A systematic search of three databases (2000–2024) was conducted, and two reviewers independently ...
Hiba J. Mustafa, Parisa Najjariasl, Faezeh Aghajani, Enaja V. Sambatur, Andrew Rodenbarger, Stephanie Guseh, Amy E. Roberts, Alireza A. Shamshirsaz   +7 more
wiley   +1 more source

Activity of direct KRAS(G12C) inhibitors in preclinical models of pediatric cancer. [PDF]

Mol Cancer Ther
Price HE, Stauffer S, Lee H, Isanogle KA, Wu Y, Powell K, Baker A, Stauffer L, Perciaccante AJ, Jewell CP, Hernandez ER, Aljabri AK, Odeniyide P, Pratilas CA, Burgan W, Edmondson EF, Difilippantonio S, Kortum RL, Shern JF, Jenkins LM, Rossman KL, Yohe ME.   +21 more
europepmc   +1 more source

Identification of aHighly Cooperative PROTAC DegraderTargeting GTP-Loaded KRAS(On) Alleles

Vesna Vetma (7953920), Ilaria Puoti (18965718), Natalia K. Karolak (22531394), Sohini Chakraborti (10736907), Emelyne Diers (2112991), Enrico Girardi (78640), Shakil Khan (22531397), Giorgia Kidd (18965715), Katrin G. Kropatsch (22531400), Ross Mclennan (22531403), Suzanne O’Connor (22531406), Matthias Samwer (19333201), Nicole Trainor (2094256), Claire Whitworth (323999), Andre J. Wijaya (22531409), Jeff Y. F. Wong (22531412), David Zollman (4751685), William Farnaby (2297479), Johannes Popow (6388691), Alessio Ciulli (762789), Peter Ettmayer (3013665), Kirsten McAulay (8921045)   +21 more
openalex   +1 more source

Evolving Features of RASopathies Among Pregnancies With Abnormal Fetal Fluid Collections

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective We aimed to characterize the fetal features across gestation and describe genotype‐phenotype correlations for pregnancies with fetal RASopathies that were more severely affected as they presented with at least one abnormal fluid collection.
Natalie B. Gulrajani, John Boscardin, Billie R. Lianoglou, Katie Tick, Carmen M. A. Santoli, Kristen A. Miller, Angie C. Jelin, Lorraine Dugoff, Rose Giardine, Cori Feist, Rachel Pilliod, Stephanie Dukhovny, Kelly Gilmore, Neeta L. Vora, Aisling Murphy, Peter N. Robinson, Mary E. Norton, Teresa N. Sparks   +17 more
wiley   +1 more source

Association of TIGIT and CD155 with KRAS, NRAS, BRAF, PIK3CA, and AKT Gene Mutations, MSI Status, and Cytokine Profiles in Colorectal Cancer. [PDF]

Int J Mol Sci
Ochman B, Limanówka P, Mielcarska S, Kula A, Dawidowicz M, Hudy D, Szrot M, Piecuch J, Czuba Z, Waniczek D, Świętochowska E.   +10 more
europepmc   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Single-dose DSS-induced inflammation enhances colorectal tumorigenesis in APC and KRAS mutant mice. [PDF]

Sci Rep
Ishibashi K, Urabe Y, Uda T, Sako Y, Gurita T, Masuda S, Hatsushika Y, Nakamura T, Konishi H, Tsuboi A, Tanaka H, Yamashita K, Kishida Y, Hiyama Y, Takigawa H, Kuwai T, Niitsu H, Hinoi T, Oka S.   +18 more
europepmc   +1 more source

Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer

Phytotherapy Research, EarlyView.
Schematic illustration of SS‐induced ferroptosis through targeting APT2‐mediated STAT3 palmitoylation in GBC cells. ABSTRACT Gallbladder cancer (GBC), the most prevalent and lethal biliary tract malignancy, lacks effective therapeutic strategies. Solasonine (SS), a bioactive steroidal alkaloid derived from Solanum nigrum L, exhibits antitumor activity ...
Liu‐qing Shi, Jing‐wei Zhao, Jia‐yun Zhu, Cheng Zhao, Zi‐yi Yang, Li‐jia Pan, Ben Ma, Zheng‐yu Chen, Zi‐ying Wang, Chun‐jie Li, Shi‐lei Liu, Jia‐wei Mei, Ping Dong   +12 more
wiley   +1 more source

KRAS-targeted therapies in cancer: novel approaches and overcoming resistance. [PDF]

BMJ Oncol
Tang D, Kroemer G, Kang R.
europepmc   +1 more source