Results 251 to 260 of about 260,030 (390)

ALKBH8-mediated codon-specific translation promotes colorectal tumorigenesis. [PDF]

Nat Commun
Qian Y, Wu C, Wei S, Yan S, Peng J, Yu L, Gao Y, Hou J, Yu W, Chen Z, Zhang J, Gao X.   +11 more
europepmc   +1 more source

KRAS Mutations [PDF]

, 2008
Gregory J. Riely, Marc Ladanyi
openalex   +1 more source

Prospective validation of the modified metastatic colorectal cancer score (mCCS) in >600 patients with RAS‐wild‐type metastatic colorectal cancer treated with first‐line panitumumab plus FOLFIRI/FOLFOX: Final results of the non‐interventional study VALIDATE

International Journal of Cancer, EarlyView.
What's New? Prognostic assessment in metastatic colorectal cancer (mCRC), which is currently based on scores derived from clinical trials, requires refinement to enhance treatment outcomes and quality of care. In this study, the authors evaluated real‐world data from the German tumor registry to prospectively validate a modified mCRC prognostic score ...
Karin Potthoff, Jens Uhlig, Lutz Jacobasch, Lothar Müller, Marcel Reiser, Rebecca de Buhr, Silke Polata, Armin Gerger, Viktor Zehrer, Arno Amann, Thomas Göhler, Laura Serrer, Jan Schröder, Dieter Semsek, Andreas Köhler, Patrick Stübs, Gerald Prager, Hans Ulrich Siebenbach, Anita Schuch, Norbert Marschner   +19 more
wiley   +1 more source

TIMP-1 Modulation Correlates with KRAS Dependency and EMT Induction in NSCLC. [PDF]

Cells
M-Thirusenthilarasan I, Ahluwalia P, Thorenoor N, Ghoshal-Gupta S, Lee BR, Siddiqui B, Kolhe R, Rojiani AM, Rojiani MV.   +8 more
europepmc   +1 more source

Patterns of EGFR, HER2, TP53, and KRAS Mutations of p14arf Expression in Non–Small Cell Lung Cancers in Relation to Smoking History

, 2007
Mounia Mounawar, Anush Mukeria, Florence Le Calvez‐Kelm, Rayjean J. Hung, Hélène Renard, Alexis B. Cortot, Claire Bollart, Давид Заридзе, Paul Brennan, Paolo Boffetta, Élisabeth Brambilla, Pierre Hainaut   +11 more
openalex   +1 more source

New cell lines expanding the diversity of Ewing sarcoma models

International Journal of Cancer, EarlyView.
What's New? A chromosomal translocation between the EWSR1 and ETS genes is the key oncogenic driver in Ewing sarcoma. EWSR1::FLI1, the most frequent fusion, is subdivided into different fusion types with unclear prognostic relevance. Here, the authors describe the establishment and characterization of four new, intrinsically immortal, patient‐derived ...
Maximilian Kerkhoff, Christiane Schaefer, Wilhelm G. Dirks, Dawid Krzeciesa, Maximilian Bretschneider, Pauline R. Plaumann, Wiebke K. Guder, Arne Streitbürger, Sonja Herter, Heike Peterziel, Ina Oehme, Felina Zahnow, Thomas G. P. Grünewald, Uta Dirksen   +13 more
wiley   +1 more source

Molecular screening of natural compounds targeting KRAS(G12C): a multi-parametric strategy against acute lymphoblastic leukemia. [PDF]

J Enzyme Inhib Med Chem
Peng J, Zheng K, Ren L, Cheng J, Feng X, Zhang R.   +5 more
europepmc   +1 more source

TBCancer: A database for exploring characteristics and functions of tissue‐biased genes in cancer

iMetaOmics, EarlyView.
This study defined 10,921 tissue‐biased genes across 54 normal tissues and 41 cancer types. Tumor‐associated tissue‐biased genes exhibit downregulation, mutations, and epigenetic modifications, correlating with poor clinical outcomes. Their inactivation promotes tumorigenesis by enhancing stemness and immune evasion, highlighting their value as ...
Zhuobin Lin, Kunhua Hu, Hongyan Sun, Xiaoqiong Bao, Lin Tang, Wei Liu, Zhixiang Zuo, Zhihang Chen   +7 more
wiley   +1 more source

KRAS mutations promote PD-L1-mediated immune escape by ETV4 in lung adenocarcinoma. [PDF]

Transl Oncol
Jia D, Wang P, Zheng S, Lei Z, Xu W, Wang Y, Pan X, Feng Q, Yang J.   +8 more
europepmc   +1 more source

USP28 Promotes Osimertinib Resistance in H1975 NSCLC Cells by Deubiquitinating and Stabilizing SIRT1

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osimertinib (OSI) resistance in non‐small cell lung cancer (NSCLC) remains a significant challenge. This report explored the precise role of USP28 on OSI resistance in NSCLC and identified a functional downstream effector. OSI‐resistant H1975 cells (H1975/OSI) were established by long‐term OSI exposure.
Hu‐Sen Fan, Xiu‐Mei Li, Jia‐Qi Gu, Hai‐Feng Wang, Zhen‐Jiang Zhang   +4 more
wiley   +1 more source