Model‐Informed Optimal Dosing of Anti‐CD47 Antibody Using Target‐Mediated Drug Disposition Model
ABSTRACT IMC‐002, an anti‐cluster of differentiation 47 (CD47) antibody, was developed as a fully human immunoglobulin (Ig) G4 monoclonal antibody targeting CD47. IMC‐002 blocks CD47–signal regulatory protein alpha (SIRPα) interactions, increasing the phagocytosis of cancer cells by macrophages. This study established a target‐mediated drug disposition
Seongmee Jeong +6 more
wiley +1 more source
Prioritization approach for circuit breakers to equip with condition monitoring devices
Circuit Breakers (CBs) play an important role in ensuring the safe operation of protection systems. Condition Monitoring (CM) devices are widely implemented to extend lifetime, and to improve the maintenance quality.
Ali Karimabadi +2 more
doaj +1 more source
Dissipation of magnetic fields in star-forming clouds with different metallicities
We study dissipation process of magnetic fields in the metallicity range $0-1 Z_{\odot}$ for contracting prestellar cloud cores. By solving non-equilibrium chemistry for important charged species including charged grains, we evaluate the drift velocity ...
Doi, Kentaro +2 more
core +1 more source
RETROSPECTIVE DIAGNOSIS OF PRIMARY IMMUNODEFICIENCIES FOR CHILDREN IN SVERDLOVSK REGION
In order to justify a need for mass screening of primary immunodeficiencies (PID) in a regional program for the newborns, we performed a retrospective study of blood spots (archived screening cards) from the babies who deceased at the first year of life (
S. S. Deryabina +4 more
doaj +1 more source
Integrating fall‐planted cereal cover crops with herbicides for weed control in dry edible beans
Abstract Field experiments were conducted in Parma and Kimberly, ID, in 2023 and 2024 to determine weed suppression by fall‐planted small grain cover crops in dry beans (Phaseolus vulgaris L.). Cover crops included barley (Hordeum vulgare L.), triticale (Triticosecale wittmack L.), and winter wheat (Triticum aestivum L.), and these treatments were ...
P. Bhattarai +3 more
wiley +1 more source
Analysis of the TREC and KREC Levels in the Dried Blood Spots of Healthy Newborns with Different Gestational Ages and Weights [PDF]
D. A. Cheremokhin +5 more
openalex +1 more source
Excited‐state proton transfer dynamics of weak and medium‐strength photoacids in reverse micelles with water and methanol cores exhibit strong micelle‐size dependences. In small micelles, proton transfer rates (~109 s−1) of these photoacids display minimal dependence on solvent acidity, indicating that restricted solvation dynamics within the confined ...
Taehyung Jang, Yoonsoo Pang
wiley +1 more source
Neonatal screening for primary immunodeficiencies (PID) provides a unique opportunity for early detection of moderate to severe immune disorders. Thus, the patients could be provided with best available therapy, due to effective treatment according to ...
I. A. Korsunskiy +5 more
doaj +1 more source
Role of Newborn Screening for Immunodeficiency in Assessing the Health Status of Children (Review)
The early period of the development of the human body, characterized by a rapid growth of organs and tissues, plays an extremely important role in health.
Gyuzyal Sh. Gafiyatullina +3 more
doaj +1 more source
Development of a Multiplex Real-Time PCR Assay for the Newborn Screening of SCID, SMA, and XLA
Numerous studies have shown evidence supporting the benefits of universal newborn screening for primary immunodeficiencies (PID) and for Spinal Muscular Atrophy (SMA).
Cristina Gutierrez-Mateo +12 more
doaj +1 more source

