Results 81 to 90 of about 789 (158)

Oral Presentation

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

Approaches to the diagnosis of immunodeficiency disorders in children with Down syndrome

Аллергология и Иммунология в Педиатрии
Relevance. Down syndrome is one of the most common genetic diseases worldwide. People with this syndrome are at risk for developing immunodeficiency conditions. The article discusses the results of a study of TREC and KREC concentrations in children with
A. Yu. Chirkova, E. G. Novopoltseva, A. A. Tarasova, K. Yu. Ozhgikhin, A. S. Veselova, I. D. Morozov, U. A. Klokova, H. F. Aksyanova, N. Yu. Smelikova, E. Yu. Baskakova, E. M. Kozlova, E. E. Larionova, E. Yu. Shumskaya, M. A. Pakhomova, A. N. Krylova   +14 more
doaj   +1 more source

ОЦЕНКА КОЛИЧЕСТВА Т-РЕЦЕПТОРНЫХ ЭКСЦИЗИОННЫХ КОЛЕЦ (TREC) И КАППА-ДЕЛЕЦИОННЫХ РЕКОМБИНАЦИОННЫХ ЭКСЦИЗИОННЫХ КОЛЕЦ (KREC) У ДЕТЕЙ С ВРОЖДЕННЫМИ ПОРОКАМИ СЕРДЦА И С ВЫНУЖДЕННОЙ ТИМЭКТОМИЕЙ

Мать и дитя в Кузбассе
Целью настоящего исследования была оценка уровней Т-рецепторных эксцизионных колец (TREC) и каппа-делеционных рекомбинационных эксцизионных колец (KREC) у детей первого года жизни с врожденными пороками сердца (ВПС) и вынужденной тимэктомией.
Андрей Владимирович Шабалдин, Юрий Иванови Ровда, Анна Викторовна Синицкая, Алена Владимировна Дадонова, Светлана Александровна Шмулевич, Иван Константинови Халивопуло, Наталья Степановна Черных   +6 more
doaj  

Clinical Characteristics of Low KREC Cases in Newborn Screening for Primary Immunodeficiency

Journal of Human Immunity
Background In Saitama Prefecture, newborn screening (NBS) for severe combined immunodeficiency (SCID) was initiated as a pilot program since September 2024. Immunoglobulin kappa chain-deleting recombination excision circles (KREC) reflect newly generated B cells and enabled NBS for B cell deficiencies.
Shota Inoue, Yuya Fujita, Ryo Kojima, Sayaka Mitani, Yu Hashimoto, Yuki Sakai, Shoichiro Tateishi, Hidetoshi Hagiwara, Fumi Hirose, Junya Take, Yujin Sekinaka, Kanako Mitsui-Sekinaka, Yoji Ueshima, Kohsuke Imai   +13 more
openaire   +1 more source

Determination of the lower normal limits for the TREC and KREC indicators in newborn using the «TREC/KREC-AMP PS» reagent set

Russian Clinical Laboratory Diagnostics, 2023
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Comparative analysis of TREC and KREC concentration levels in children at medical and biological risk (CHD – frequently ill children, children who have been operated for congenital heart defect with combined thymectomy, children – without it) and those conditionally healthy

Медицинская иммунология
The purpose of the study was to compare and analyze the levels of KREC (kappa-deleting recombination excision circle) and TREC (T cell receptor excision circle) levels, which indirectly reflect impaired maturation of T and/or B lymphocytes, in children ...
Yu. I. Rovda, A. V. Vedernikova, A. V. Shabaldin, M. L. Filipenko, A. A. Sinitskaya, I. K. Khalivopulo, E. O. Grishacheva, G. A. Otstavnov, Ya. V. Shkitin, N. N. Minyailova, T. S. Khobotkova, V. V. Dadonov   +11 more
doaj   +1 more source

Efficiency of combined endocrine therapy with CDK4/6 inhibitors in metastatic HR⁺/HER2^- breast cancer: Immunological aspects

Медицинская иммунология
Luminal HER2-negative subtypes of breast cancer have always attracted oncologists due to their sensitivity to low-toxicity hormone therapy. The emergence of new inhibitors of cyclin-dependent kinases has allowed hormone therapy to achieve optimal control
A. V. Sultanbaev, I. A. Tuzankina, I. V. Kolyadina, A. F. Nasretdinov, Sh. I. Musin, N. I. Sultanbaeva, K. V. Menshikov, A. A. Izmailov, M. V. Sultanbaev, D. A. Kudlay   +9 more
doaj   +1 more source

Possibilities of Immunogenetic Methods in Testing the Activity of Tuberculosis Infection in Children

Туберкулез и болезни лёгких
The objective: to test the TREC/KREC DNA levels in children with various manifestations of tuberculosis infection.Subjects and Methods. A prospective, cross-sectional study was conducted in 2022-2024. Observation Group consisted of 115 children aged 6 (5;
M. A. Plekhanova, N. I. Klevno, N. V. Gordeeva, O. A. Kalinina, R. I. Ludanny, A. D. Pakhlavonova   +5 more
doaj   +1 more source

Recombination Excision Circle (KREC) Immunoglobulin Gene Rearrangement Mechamism and Importance in Transplants [PDF]

Turkish Journal of Immunology, 2021
Zeynep Akbulut, Gulderen Yanikkaya Demirel   +1 more
openaire   +1 more source

First 2-year experience of nationwide newborn screening for severe forms of T and B cell immunodeficiency: 2.3 million newborns analyzed using TREC and KREC in Russia. [PDF]

Front Immunol
Marakhonov A, Mukhina A, Efimova I, Balinova N, Ampleeva M, Bobreshova A, Rodina Y, Pershin D, Zabnenkova V, Ryzhkova O, Markova Z, Shilova N, Zhanin I, Savostyanov K, Matulevich S, Bilalov F, Koroteev A, Donnikov A, Trofimov D, Bairova T, Seitova G, Mordanov S, Nikolaeva E, Esmurzieva Z, Skorobogatova E, Olkhova L, Vakhonina L, Kostenko D, Bronin G, Zimin S, Bykova T, Balashov D, Zinchenko R, Grachev N, Voronin S, Shcherbina A, Kutsev S.   +36 more
europepmc   +1 more source