Results 141 to 150 of about 1,834 (180)

Initiation of lumen formation from junctions via differential actomyosin contractility regulated by dynamic recruitment of Rasip1. [PDF]

Nat Commun
Yin J, Schellinx N, Maggi L, Gundel K, Wiesner C, Kotini MP, Lee M, Phng LK, Belting HG, Affolter M.   +9 more
europepmc   +1 more source

Modulating splicing in 5’ untranslated regions to treat rare haploinsufficient disease

Beer Wells ES, De Conti L, Kim HC, Rohani N, Chundru K, Watts LM, Dawes R, Chen Y, Martin-Geary AC, Griffiths MJ, Scott S, Bamford RA, Mill J, Wright CF, Baralle M, Sanders SJ, Whiffin N.   +16 more
europepmc   +1 more source

KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction [PDF]

International Journal of Molecular Sciences, 2019
Loss-of-function mutations of the gene encoding Krev interaction trapped protein 1 (KRIT1) are associated with the pathogenesis of Cerebral Cavernous Malformation (CCM), a major cerebrovascular disease characterized by abnormally enlarged and leaky ...
Paolo Pinton, Paola Rizzo, Andrea Perrelli   +2 more
exaly   +6 more sources

KRIT1 as a Possible New Player in Melanoma Aggressiveness

Archives of Biochemistry and Biophysics, 2020
Krev interaction trapped protein 1 (KRIT1) is a scaffold protein known to form functional complexes with distinct proteins, including Malcavernin, PDCD10, Rap1 and others. It appears involved in several cellular signaling pathways and exerts a protective
Clelia Miracco, Lorenza Trabalzini, Giuseppe Valacchi   +2 more
exaly   +7 more sources

miR-21 Coordinates Tumor Growth and Modulates KRIT1 Levels [PDF]

Biochemical and Biophysical Research Communications, 2013
miR-21 is overexpressed in tumors and it displays oncogenic activity. Here, we show that expression of miR-21 in primary tumors anticorrelates with KRIT1/CCM1, an interacting partner of the Ras-like GTPase Rap1, involved in Cerebral Cavernous ...
Saverio Francesco Retta, Daniela Taverna, Francesca Orso   +2 more
exaly   +8 more sources

Heterozygous Loss of KRIT1 in Mice Affects Metabolic Functions of the Liver, Promoting Hepatic Oxidative and Glycative Stress [PDF]

International Journal of Molecular Sciences, 2022
KRIT1 loss-of-function mutations underlie the pathogenesis of Cerebral Cavernous Malformation (CCM), a major vascular disease affecting the central nervous system (CNS).
Andrea Perrelli, Saverio Francesco Retta, Raffaella Mastrocola   +2 more
exaly   +2 more sources

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KRIT1 ‐mediated regulation of neutrophil adhesion and motility

The FEBS Journal, 2022
Loss of Krev interaction‐trapped‐1 (KRIT1) expression leads to the development of cerebral cavernous malformations (CCM), a disease in which abnormal blood vessel formation compromises the structure and function of the blood–brain barrier. The role of KRIT1 in regulating endothelial function is well‐established.
Nicholas Nobiletti, Jing Liu, Angela J. Glading   +2 more
openaire   +2 more sources

Production of KRIT1-knockout and KRIT1-knockin Mouse Embryonic Fibroblasts as Cellular Models of CCM Disease

2020
The development of distinct cellular and animal models has allowed the identification and characterization of molecular mechanisms underlying the pathogenesis of cerebral cavernous malformation (CCM) disease. This is a major cerebrovascular disorder of proven genetic origin, affecting 0.5% of the population.
Goitre L., Fornelli C., Zotta A., Perrelli A., Retta S. F.   +4 more
openaire   +3 more sources