Results 161 to 170 of about 2,405 (204)
CCM Function in the Heart: Working From Outside-In Rather Than Inside-Out. [PDF]
JACC Basic Transl SciKahn ML.
europepmc +1 more source
Proteomic Dynamics of Multidrug Resistance Mechanisms in Lucena 1 Cell Line. [PDF]
CellsBeraldo-Neto E +5 more
europepmc +1 more source
Tumor microenvironment-driven microRNA dysregulation: Key interactions in colorectal cancer progression. [PDF]
World J Gastrointest OncolQuiroz-Reyes AG +8 more
europepmc +1 more source
KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction [PDF]
International Journal of Molecular Sciences, 2019 Loss-of-function mutations of the gene encoding Krev interaction trapped protein 1 (KRIT1) are associated with the pathogenesis of Cerebral Cavernous Malformation (CCM), a major cerebrovascular disease characterized by abnormally enlarged and leaky capillaries and affecting 0.5% of the human population. However, growing evidence demonstrates that KRIT1
Francesco Vieceli Dalla Sega +2 more
exaly +3 more sources
KRIT1 as a possible new player in melanoma aggressiveness
Archives of Biochemistry and Biophysics, 2020 Krev interaction trapped protein 1 (KRIT1) is a scaffold protein known to form functional complexes with distinct proteins, including Malcavernin, PDCD10, Rap1 and others. It appears involved in several cellular signaling pathways and exerts a protective role against inflammation and oxidative stress.
Federica Finetti +2 more
exaly +6 more sources
miR-21 coordinates tumor growth and modulates KRIT1 levels
Biochemical and Biophysical Research Communications, 2013 miR-21 is overexpressed in tumors and it displays oncogenic activity. Here, we show that expression of miR-21 in primary tumors anticorrelates with KRIT1/CCM1, an interacting partner of the Ras-like GTPase Rap1, involved in Cerebral Cavernous Malformations (CCM).
Francesca Orso +2 more
exaly +6 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Loss of Krev interaction‐trapped‐1 (KRIT1) expression leads to the development of cerebral cavernous malformations (CCM), a disease in which abnormal blood vessel formation compromises the structure and function of the blood–brain barrier. The role of KRIT1 in regulating endothelial function is well‐established.
Nicholas Nobiletti +2 more
openaire +2 more sources
Journal of Molecular Neuroscience, 2010
Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in seizures, haemorrhage, recurrent headaches and focal neurologic deficit. CCMs can occur as an autosomal dominant trait with incomplete penetrance and a wide phenotypic variability.
PILEGGI, S. +7 more
openaire +8 more sources
Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in seizures, haemorrhage, recurrent headaches and focal neurologic deficit. CCMs can occur as an autosomal dominant trait with incomplete penetrance and a wide phenotypic variability.
PILEGGI, S. +7 more
openaire +8 more sources
2020
The development of distinct cellular and animal models has allowed the identification and characterization of molecular mechanisms underlying the pathogenesis of cerebral cavernous malformation (CCM) disease. This is a major cerebrovascular disorder of proven genetic origin, affecting 0.5% of the population.
Goitre L. +4 more
openaire +3 more sources
The development of distinct cellular and animal models has allowed the identification and characterization of molecular mechanisms underlying the pathogenesis of cerebral cavernous malformation (CCM) disease. This is a major cerebrovascular disorder of proven genetic origin, affecting 0.5% of the population.
Goitre L. +4 more
openaire +3 more sources