Results 41 to 50 of about 1,864 (178)
Antioxidants and Redox Signaling, 2022 Significance: KRIT1 (Krev interaction trapped 1) is a scaffolding protein that plays a critical role in vascular morphogenesis and homeostasis.
A. Perrelli +4 more
semanticscholar +1 more source
Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation [PDF]
Molecular Cell, 2013 KRIT1 (Krev/Rap1 Interaction Trapped-1) mutations are observed in ∼40% of autosomal-dominant cerebral cavernous malformations (CCMs), a disease occurring in up to 0.5% of the population. We show that KRIT1 functions as a switch for β1 integrin activation by antagonizing ICAP1 (Integrin Cytoplasmic Associated Protein-1)-mediated modulation of "inside ...
Liu, Weizhi +4 more
openaire +5 more sources
Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis
eLife, 2018 Endothelial cells respond to different levels of fluid shear stress through adaptations of their mechanosensitivity. Currently, we lack a good understanding of how this contributes to sculpting of the cardiovascular system.
Stefan Donat +5 more
doaj +1 more source
PLoS ONE, 2015 Cerebral cavernous malformations are fragile blood vessel conglomerates in the central nervous system that are caused by mutations in the CCM1/KRIT1, CCM2 or CCM3 genes.
Stefanie E Herberich +5 more
doaj +1 more source
Clinicoradiologic data of familial cerebral cavernous malformation with age‐related disease burden
Annals of Clinical and Translational Neurology, 2023 Objective Familial cerebral cavernous malformation (FCCM) is an autosomal dominant disease induced by loss‐of‐function mutations in three CCM genes, KRIT1, CCM2, and PDCD10.
Seondeuk Kim +8 more
doaj +1 more source
Unexpected distribution of KRIT1 inside the nucleus: new insight in a complex molecular pathway
European Journal of Histochemistry, 2014 KRIT1 is an 84kDa protein that lacks any relevant catalytic domains, associated with the cerebral cavernous malformation disease. We have investigated by means of ultrastructural immunocytochemistry the nuclear distribution of KRIT1 in different cell ...
S. Marzo, V. Galimberti, M. Biggiogera
doaj +1 more source
Frontiers in Neuroscience, 2020 Cerebral cavernous malformations (CCMs) are vascular lesions that predominantly occur in the brain. CCMs can be sporadic or hereditary in an autosomal dominant manner. The genes harboring variants of familial CCMs (FCCMs) include CCM1/KRIT1, CCM2/MGC4607,
Fan Zhang +10 more
doaj +1 more source
Journal of Molecular Neuroscience, 2021 Cerebral cavernous malformations (CCMs) are vascular malformations that may result in headaches, seizures, focal neurological deficits, and hemorrhage. CCMs occur sporadically (80%) or in familial form (20%), with autosomal dominant inheritance.
C. Ricci +4 more
semanticscholar +1 more source
Journal of Cell Science, 2021 Krev-interaction trapped protein 1 (KRIT1) is an endothelial scaffold protein that promotes adherens junction (AJ) stability. The precise mechanism by which KRIT1 promotes barrier stabilization is unclear.
Harsha Swamy, A. Glading
semanticscholar +1 more source
Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier. [PDF]
PLoS ONE, 2016 The phosphoinositide-specific phospholipase C, PLCε, is a unique signaling protein with known roles in regulating cardiac myocyte growth, astrocyte inflammatory signaling, and tumor formation. PLCε is also expressed in endothelial cells, however its role
Peter V DiStefano +2 more
doaj +1 more source