Results 31 to 40 of about 1,864 (178)

VEGF signalling enhances lesion burden in KRIT1 deficient mice [PDF]

Journal of Cellular and Molecular Medicine, 2019
The exact molecular mechanisms underlying CCM pathogenesis remain a complicated and controversial topic. Our previous work illustrated an important VEGF signalling loop in KRIT1 depleted endothelial cells.
Peter V. DiStefano, A. Glading
semanticscholar   +3 more sources

microRNA-Mediated Regulation of Oxidative Stress in Cardiovascular Diseases. [PDF]

J Clin Lab Anal
ABSTRACT Background Cardiovascular diseases (CVDs) are the leading cause of mortality globally, often linked to oxidative stress. MicroRNAs (miRNAs) have emerged as significant regulators of oxidative stress within the cardiovascular system. Objective This review examines the complex relationship between miRNAs and oxidative stress, clarifying their ...
Abolhasani S, Ahmadi Y, Fattahi D, Rostami Y, Chollou KM.   +4 more
europepmc   +2 more sources

MicroRNA-1185 Induces Endothelial Cell Apoptosis by Targeting UVRAG and KRIT1 [PDF]

Cellular Physiology and Biochemistry, 2017
Background/Aims: Atherosclerosis is a multifactorial chronic disease and is the main cause of death and impairment in the world. Endothelial injury and apoptosis play a crucial role in the onset and development of atherosclerosis. MicroRNAs (miRNAs) have
Haoyuan Deng, Xia Chu, Zhenfeng Song, Xinrui Deng, Huan Xu, Yaxin Ye, Songtao Li, Qiao Zhang, Changhao Sun, Ying Li   +9 more
doaj   +3 more sources

Initiation of lumen formation from junctions via differential actomyosin contractility regulated by dynamic recruitment of Rasip1 [PDF]

Nature Communications
De novo lumen formation necessitates the precise segregation of junctional proteins from apical surfaces, yet the underlying mechanisms remain unclear. Using a zebrafish model, we develop a series of molecular reporters, photo-convertible and optogenetic
Jianmin Yin, Niels Schellinx, Ludovico Maggi, Kathrin Gundel, Cora Wiesner, Maria Paraskevi Kotini, Minkyoung Lee, Li-Kun Phng, Heinz-Georg Belting, Markus Affolter   +9 more
doaj   +2 more sources

GERM-LINE/SOMATIC DNA COMPARISON IN SPORADIC PATIENTS WITH CEREBRAL CAVERNOUS MALFORMATIONS.

Euromediterranean Biomedical Journal, 2017
Cerebral cavernous malformations (CCMs) are benign tumours that affect brain capillaries. Although many cases remain asymptomatic, their incidence is steadily increasing.
Ivan Anchesi
doaj   +3 more sources

21229. NUEVA MUTACIÓN EN KRIT1 COMO CAUSANTE DE CAVERNOMATOSIS FAMILIAR

Neurology Perspectives
L. Delgado Bárcena, C. Fernández Ramajo, B. Sancho Valderrama, L. Romano Flores, M. Gallego Prieto, N. Arteta Gutiérrez, A. Bonilla Zhañay, E. Madrigal Lkhou, S. Ortega Cubero   +8 more
doaj   +2 more sources

A Novel CCM2 Missense Variant Caused Cerebral Cavernous Malformations in a Chinese Family

Frontiers in Neuroscience, 2021
Cerebral cavernous malformations (CCMs) are common vascular malformations in the central nervous system. Familial CCMs (FCCMs) are autosomal dominant inherited disease with incomplete penetrance and variable symptoms.
Guoqing Han, Li Ma, Huanhuan Qiao, Lin Han, Qiaoli Wu, Qingguo Li   +5 more
doaj   +1 more source

Next-Generation Sequencing Advances the Genetic Diagnosis of Cerebral Cavernous Malformation (CCM)

Antioxidants, 2022
Cerebral Cavernous Malformation (CCM) is a cerebrovascular disease of genetic origin that predisposes to seizures, focal neurological deficits and fatal intracerebral hemorrhage. It may occur sporadically or in familial forms, segregating as an autosomal
Valerio Benedetti, Rosalia Canzoneri, Andrea Perrelli, Carlo Arduino, Andrea Zonta, Alfredo Brusco, Saverio Francesco Retta   +6 more
doaj   +1 more source

A Chinese Family With Cerebral Cavernous Malformation Caused by a Frameshift Mutation of the CCM1 Gene: A Case Report and Review of the Literature

Frontiers in Neurology, 2022
BackgroundFamilial cerebral cavernous malformation (FCCM) is a vascular malformation disease closely linked to three identified genes: KRIT1/CCM1, MGC4607/CCM2 and PDCD10/CCM3.
Wenyu Liu, Wenyu Liu, Ming Liu, Ming Liu, Di Lu, Di Lu, Jiwei Wang, Jiwei Wang, Zexin Cao, Zexin Cao, Xuchen Liu, Xuchen Liu, Zichao Feng, Zichao Feng, Bin Huang, Bin Huang, Xinyu Wang, Xinyu Wang   +17 more
doaj   +1 more source

Identification of the Kelch family protein Nd1-L as a novel molecular interactor of KRIT1.

PLoS ONE, 2012
Loss-of-function mutations of the KRIT1 gene (CCM1) have been associated with the Cerebral Cavernous Malformation (CCM) disease, which is characterized by serious alterations of brain capillary architecture.
Paolo Guazzi, Luca Goitre, Elisa Ferro, Valentina Cutano, Chiara Martino, Lorenza Trabalzini, Saverio Francesco Retta   +6 more
doaj   +1 more source