Results 11 to 20 of about 1,864 (178)

KRIT1 in vascular biology and beyond. [PDF]

Biosci Rep
KRIT1 is a 75 kDa scaffolding protein which regulates endothelial cell phenotype by limiting the response to inflammatory stimuli and maintaining a quiescent and stable endothelial barrier.
Glading AJ.
europepmc   +4 more sources

KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction [PDF]

International Journal of Molecular Sciences, 2019
Loss-of-function mutations of the gene encoding Krev interaction trapped protein 1 (KRIT1) are associated with the pathogenesis of Cerebral Cavernous Malformation (CCM), a major cerebrovascular disease characterized by abnormally enlarged and leaky ...
Francesco Vieceli Dalla Sega, Raffaella Mastrocola, Giorgio Aquila   +2 more
exaly   +4 more sources

KRIT1 as a possible new player in melanoma aggressiveness

Archives of Biochemistry and Biophysics, 2020
Krev interaction trapped protein 1 (KRIT1) is a scaffold protein known to form functional complexes with distinct proteins, including Malcavernin, PDCD10, Rap1 and others. It appears involved in several cellular signaling pathways and exerts a protective
Federica Finetti, Brittany Woodby, Clélia Miracco   +2 more
exaly   +7 more sources

KRIT1 could serve as a prognostic biomarker for glioma patients

Asian Journal of Surgery
Xiaozhu Zhou, Fanglin Shao, Yujie Xie, Chi Zhang   +3 more
doaj   +4 more sources

The Role of Immune Infiltration and Oxidative Stress in the Progression of Cerebral Cavernous Malformation. [PDF]

Brain Behav
Mechanism of rupture hemorrhage in cerebral cavernous malformations. Environmental and immune factors promote the progression of lesions and induce the risk of abnormal formation or rupture of cerebrovascular vessels. Abstract Purpose of Review To review how the immune microenvironment and oxidative stress modulate the initiation, maturation, and ...
Zhu X, Yao Y, Yu T, Xiao X.
europepmc   +2 more sources

Silencing <i>KRIT1</i> Partially Reverses the Effects of Disturbed Flow on the Endothelial Cell Transcriptome. [PDF]

Int J Mol Sci
Background Endothelial cells respond to forces generated by laminar blood flow with changes in vasodilation, anticoagulant, fibrinolytic, or anti-inflammatory functions which preserve vessel patency.
Meecham A, McCurdy S, Frias-Anaya E, Li W, Gallego-Gutierrez H, Nguyen P, Li YS, Chien S, Shyy JY, Ginsberg MH, Lopez-Ramirez MA.   +10 more
europepmc   +2 more sources

Unveiling a Novel Molecular Interaction and Pro-Metastatic Signaling Cascades Driven by KRIT1. [PDF]

Int J Mol Sci
K-Rev Interaction Trapped protein-1 (KRIT1) is a scaffold protein that forms functional protein complexes involved in physiologically important signaling networks. While it is primarily recognized for its association with Cerebral Cavernous Malformations
Paradisi L, Guazzi P, Macis M, Finetti F, Trezza A, De Paolo R, Roncetti M, Marshall JF, Poliseno L, Finetti F, Trabalzini L.   +10 more
europepmc   +2 more sources

Heterozygous Loss of KRIT1 in Mice Affects Metabolic Functions of the Liver, Promoting Hepatic Oxidative and Glycative Stress

International Journal of Molecular Sciences, 2022
KRIT1 loss-of-function mutations underlie the pathogenesis of Cerebral Cavernous Malformation (CCM), a major vascular disease affecting the central nervous system (CNS).
Raffaella Mastrocola, Eleonora Aimaretti, Gustavo Ferreira Alves   +2 more
exaly   +2 more sources

KRIT1 regulates the homeostasis of intracellular reactive oxygen species.

PLoS ONE, 2010
KRIT1 is a gene responsible for Cerebral Cavernous Malformations (CCM), a major cerebrovascular disease characterized by abnormally enlarged and leaky capillaries that predispose to seizures, focal neurological deficits, and fatal intracerebral ...
Luca Goitre, Fiorella Balzac, Simona Degani, Paolo Degan, Saverio Marchi, Paolo Pinton, Saverio Francesco Retta   +6 more
doaj   +3 more sources

Familial Cerebral Cavernous Malformations: Pathophysiology, Genetics, Biomarkers, and Treatment Perspectives. [PDF]

J Neurochem
Cerebral cavernous malformations (CCMs) are vascular lesions in the brain caused by inherited genetic mutations in the CCM1/2/3 genes that disrupt normal blood vessel function. This work demonstrates that these mutations lead to endothelial dysfunction, inflammation, and iron accumulation, which can be detected by magnetic resonance imaging (MRI) and ...
Fontes-Dantas FL, da Fontoura Galvão G, Cunha AM, de Sena Murteira Pinheiro P, Morandi V, de Souza JM.   +5 more
europepmc   +2 more sources