Results 11 to 20 of about 2,405 (204)
KRIT1 regulates the homeostasis of intracellular reactive oxygen species. [PDF]
PLoS ONE, 2010 KRIT1 is a gene responsible for Cerebral Cavernous Malformations (CCM), a major cerebrovascular disease characterized by abnormally enlarged and leaky capillaries that predispose to seizures, focal neurological deficits, and fatal intracerebral ...
Luca Goitre +6 more
doaj +6 more sources
Correction: KRIT1 Regulates the Homeostasis of Intracellular Reactive Oxygen Species.
PLoS ONE, 2019 [This corrects the article DOI: 10.1371/journal.pone.0011786.].
PLOS ONE staff
doaj +3 more sources
MicroRNA-1185 Induces Endothelial Cell Apoptosis by Targeting UVRAG and KRIT1 [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: Atherosclerosis is a multifactorial chronic disease and is the main cause of death and impairment in the world. Endothelial injury and apoptosis play a crucial role in the onset and development of atherosclerosis. MicroRNAs (miRNAs) have
Haoyuan Deng +9 more
doaj +3 more sources
GERM-LINE/SOMATIC DNA COMPARISON IN SPORADIC PATIENTS WITH CEREBRAL CAVERNOUS MALFORMATIONS.
Euromediterranean Biomedical Journal, 2017 Cerebral cavernous malformations (CCMs) are benign tumours that affect brain capillaries. Although many cases remain asymptomatic, their incidence is steadily increasing.
Ivan Anchesi
doaj +3 more sources
The Role of Immune Infiltration and Oxidative Stress in the Progression of Cerebral Cavernous Malformation. [PDF]
Brain BehavMechanism of rupture hemorrhage in cerebral cavernous malformations. Environmental and immune factors promote the progression of lesions and induce the risk of abnormal formation or rupture of cerebrovascular vessels. Abstract Purpose of Review To review how the immune microenvironment and oxidative stress modulate the initiation, maturation, and ...
Zhu X, Yao Y, Yu T, Xiao X.
europepmc +2 more sources
KRIT1 loss of function causes a ROS-dependent upregulation of c-Jun [PDF]
Free Radical Biology and Medicine, 2014 Loss-of-function mutations in the KRIT1 gene (CCM1) have been associated with the pathogenesis of cerebral cavernous malformations (CCM), a major cerebrovascular disease.
Biasi, Fiorella +9 more
core +5 more sources
Familial Cerebral Cavernous Malformations: Pathophysiology, Genetics, Biomarkers, and Treatment Perspectives. [PDF]
J NeurochemCerebral cavernous malformations (CCMs) are vascular lesions in the brain caused by inherited genetic mutations in the CCM1/2/3 genes that disrupt normal blood vessel function. This work demonstrates that these mutations lead to endothelial dysfunction, inflammation, and iron accumulation, which can be detected by magnetic resonance imaging (MRI) and ...
Fontes-Dantas FL +5 more
europepmc +2 more sources
Protein kinase Cα regulates the nucleocytoplasmic shuttling of KRIT1 [PDF]
Free Radical Biology and Medicine, 2021 ABSTRACT KRIT1 is a scaffolding protein that regulates multiple molecular mechanisms, including cell–cell and cell–matrix adhesion, and redox homeostasis and signaling. However, rather little is known about how KRIT1 is itself regulated.
Elisa De Luca +9 more
openaire +3 more sources
KRIT1 in vascular biology and beyond. [PDF]
Biosci RepAbstract KRIT1 is a 75 kDa scaffolding protein which regulates endothelial cell phenotype by limiting the response to inflammatory stimuli and maintaining a quiescent and stable endothelial barrier. Loss-of-function mutations in KRIT1 lead to the development of cerebral cavernous malformations (CCM), a disease marked by the formation ...
Glading AJ.
europepmc +3 more sources
Frontiers in Oncology, 2023 Cerebral cavernous malformation (CCM) is a vascular malformation of the central nervous system and mainly characterized by enlarged capillary cavities without intervening brain parenchyma. Genetic studies have identified three disease-causing genes (CCM1/
Zhenxing Liu +3 more
doaj +1 more source