KRIT1 regulates the homeostasis of intracellular reactive oxygen species. [PDF]
PLoS ONE, 2010 KRIT1 is a gene responsible for Cerebral Cavernous Malformations (CCM), a major cerebrovascular disease characterized by abnormally enlarged and leaky capillaries that predispose to seizures, focal neurological deficits, and fatal intracerebral ...
Luca Goitre +6 more
doaj +7 more sources
Protein kinase Cα regulates the nucleocytoplasmic shuttling of KRIT1 [PDF]
Free Radical Biology and Medicine, 2020 KRIT1 is a scaffolding protein that regulates multiple molecular mechanisms, including cell-cell and cell-matrix adhesion, and redox homeostasis and signaling. However, rather little is known about how KRIT1 is itself regulated.
Perrelli, Andrea +22 more
core +5 more sources
Identification of the Kelch family protein Nd1-L as a novel molecular interactor of KRIT1. [PDF]
PLoS ONE, 2012 Loss-of-function mutations of the KRIT1 gene (CCM1) have been associated with the Cerebral Cavernous Malformation (CCM) disease, which is characterized by serious alterations of brain capillary architecture.
Paolo Guazzi +6 more
doaj +2 more sources
Journal of Molecular Neuroscience, 2010 Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in seizures, haemorrhage, recurrent headaches and focal neurologic deficit.
Patrosso M. C. +7 more
core +10 more sources
Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium [PDF]
Scientific Reports, 2017 The intracellular scaffold KRIT1/CCM1 is an established regulator of vascular barrier function. Loss of KRIT1 leads to decreased microvessel barrier function and to the development of the vascular disorder Cerebral Cavernous Malformation (CCM).
Luca Goitre +12 more
doaj +2 more sources
Data in support of sustained upregulation of adaptive redox homeostasis mechanisms caused by KRIT1 loss-of-function [PDF]
Data in Brief, 2018 This article contains additional data related to the original research article entitled “KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: implication for Cerebral Cavernous ...
Cinzia Antognelli +8 more
doaj +2 more sources
Correction: KRIT1 Regulates the Homeostasis of Intracellular Reactive Oxygen Species.
PLoS ONE, 2019 [This corrects the article DOI: 10.1371/journal.pone.0011786.].
PLOS ONE staff
doaj +3 more sources
ROLE OF KRIT1 IN THE ACQUISITION OF AGGRESSIVE PHENOTYPE IN CANCER CELLS [PDF]
K-Rev Interaction Trapped protein-1 (KRIT1) is a scaffold protein known to form functional protein complexes involved in physiologically important signaling networks.
Paradisi, Lucrezia
core +3 more sources
MicroRNA-1185 Induces Endothelial Cell Apoptosis by Targeting UVRAG and KRIT1 [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: Atherosclerosis is a multifactorial chronic disease and is the main cause of death and impairment in the world. Endothelial injury and apoptosis play a crucial role in the onset and development of atherosclerosis. MicroRNAs (miRNAs) have
Haoyuan Deng +9 more
doaj +3 more sources
C329X in KRIT1 is a founder mutation among CCM patients in Sardinia
European Journal of Medical Genetics, 2009 Cerebral cavernous malformations(CCMs)are CNS vascular anomalies associated with seizures,head- aches and hemorrhagic strokes and represent 10–20% of cerebral lesions.CCM is present in 0.1–0.5 of the population.This disorder most often occurs ...
LOI M +17 more
core +3 more sources