Results 81 to 90 of about 1,834 (180)
Identification of the KRIT1 protein by LexA-based yeast two-hybrid system
, 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020. Cerebral cavernous malformation (CCM) is a vascular malformation of the central nervous system that is associated with leaky capillaries, and a predisposition to serious clinical ...
Elmekawy M. +2 more
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Frontiers in Surgery, 2016 Mutations in the genes KRIT1, CCM2, and PDCD10 are known to result in the formation of cerebral cavernous malformations (CCMs). CCMs are intracranial lesions comprised of aberrantly enlarged cavernous endothelial channels that can result in cerebral ...
Jacob F. Baranoski +2 more
doaj +1 more source
, 2000 Hyperkeratotic capillary-venous malformations (HCCVMs) are rare cutaneous lesions that occur in a small subgroup of patients with cerebral capillary malformation (CCM).
Boon, Laurence M. +5 more
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Molecular diagnosis in cerebral cavernous malformations
Neurología (English Edition), 2017 Introduction: Cerebral cavernous malformations (CCMs; OMIM 116860) are enlarged vascular cavities without intervening brain parenchyma whose estimated prevalence in the general population is between 0.1% and 0.5%.
R. Mondejar, M. Lucas
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Diagnóstico molecular de cavernomatosis cerebral
Neurología, 2017 Resumen: Introducción: Las malformaciones cavernosas cerebrales (CCM; OMIM 116860) son engrosamientos cavernosos vasculares sin intervención del parénquima cerebral con una prevalencia estimada en la población general del 0,1-0,5%.
R. Mondejar, M. Lucas
doaj +1 more source
, 2020 Endothelial cells (EC) line the entire circulatory system and control the passage of materials into and out of the bloodstream. EC dysfunction is damage to EC that impairs the function of the endothelium, and plays a central role in the development of ...
Rojas, Antonio, Gingras, Alex, Dr.
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KRIT1 LOSS-OF-FUNCTION INDUCES ANGIOGENESIS AND MIGRATION IN A CCM CELLULAR MODEL
, 2019 KRIT1 is a gene involved in Cerebral Cavernous Malformations (CCMs), a cerebrovascular disease characterized by thin-walled capillaries lacking of normal vessel structure that predispose to headaches, neurological deficits, seizures, stroke and ...
SCHIAVO, IRENE
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KRIT1-Mediated Regulation of the Cellular Response to Inflammation
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Pharmacology and Physiology, 2023.Cerebral cavernous malformations (CCM) is a disease in which abnormal blood vessel formation compromises the structure and function of the
Glading, Angela J., Nobiletti, Nicholas
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Regulation of Endothelial Cell Behavior via KRIT1 Localization and Function
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Pharmacology and Physiology, 2022.Stable endothelial barrier function is necessary for vascular homeostasis. Disruption of endothelial cell-cell contacts leads to a loss of
Glading, Angela J., Swamy, Harsha
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Loss of KRIT1 in PLCε depleted HPAEC prevents rescue by 8-pCPT-2′-O-Me-cAMP-AM and wild type PLCε.
, 2016 A) HRP leak through HPAEC monolayer infected with negative control (NC) or PLCε siRNA ± anti-KRIT1 siRNA or 1μM 8-pCPT-2′-O-Me-cAMP-AM (cPT-2OMe). Data shown are the mean HRP concentration, ± SEM. n = 9, pB) HRP leak through HPAEC monolayer infected with
Peter V. DiStefano (3111639) +2 more
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