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Nuclear Localization of Integrin Cytoplasmic Domain-associated Protein-1 (ICAP1) Influences β1 Integrin Activation and Recruits Krev/Interaction Trapped-1 (KRIT1) to the Nucleus [PDF]

Journal of Biological Chemistry, 2017
Binding of ICAP1 (integrin cytoplasmic domain-associated protein-1) to the cytoplasmic tails of β1 integrins inhibits integrin activation. ICAP1 also binds to KRIT1 (Krev interaction trapped-1), a protein whose loss of function leads to cerebral cavernous malformation, a cerebrovascular dysplasia occurring in up to 0.5% of the population. We previously
Bertrand Simon, David A Calderwood
exaly   +3 more sources

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Identification of a novel KRIT1 mutation in an Italian family with cerebral cavernous malformation by the protein truncation test

Journal of the Neurological Sciences, 2003
Familial cerebral cavernous malformation (CCM) exhibits autosomal dominant inheritance and is characterized by vascular disorders of the brain, which can lead to seizures, focal neurological deficits, hemorrhagic stroke, and migraine. Three CCM loci have been mapped, but the gene for only one locus--KRIT1 coding for Krev-1/rap1 interaction trapped 1 ...
Loretta Ferrera, Giuseppe Viale
exaly   +3 more sources

Structural Basis for Small G Protein Effector Interaction of Ras-related Protein 1 (Rap1) and Adaptor Protein Krev Interaction Trapped 1 (KRIT1) [PDF]

Journal of Biological Chemistry, 2012
Cerebral cavernous malformations (CCMs) affect 0.1-0.5% of the population resulting in leaky vasculature and severe neurological defects. KRIT1 (Krev interaction trapped-1) mutations associate with ∼40% of familial CCMs. KRIT1 is an effector of Ras-related protein 1 (Rap1) GTPase.
Wei-zhi Liu, Titus J Boggon, David A Calderwood   +2 more
exaly   +3 more sources

Sorting nexin 17, a non-self-assembling and a PtdIns(3)P high class affinity protein, interacts with the cerebral cavernous malformation related protein KRIT1

Biochemical and Biophysical Research Communications, 2006
The mammalian sorting nexin (SNX) proteins are involved in the endocytosis and the sorting machinery of transmembrane proteins. Additionally to the family defining phox homology (PX) domain, SNX17 is the only member with a truncated FERM (4.1, ezrin, radixin, and moesin) domain and a unique C-terminal region (together designated as FC unit).
Peter Knauth
exaly   +3 more sources

Identification of the KRIT1 Protein by LexA-Based Yeast Two-Hybrid System

2020
Cerebral cavernous malformation (CCM) is a vascular malformation of the central nervous system that is associated with leaky capillaries, and a predisposition to serious clinical conditions including intracerebral hemorrhage and seizures. Germline or sporadic mutations in the CCM1/KRIT1 gene are responsible for the majority of cases of CCM.
Serebriiskii I.G., Elmekawy M., Golemis E.A.   +2 more
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KRIT1/Cerebral Cavernous Malformation 1 Protein Localizes to Vascular Endothelium, Astrocytes, and Pyramidal Cells of the Adult Human Cerebral Cortex

Neurosurgery, 2004
Mutations in KRIT1 cause familial cerebral cavernous malformation, an autosomal dominant disorder affecting primarily the central nervous system vasculature. Although recent studies have suggested that Krev-1 interaction trapped 1 (KRIT1) is a microtubule-associated protein that interacts with integrin cytoplasmic domain-associated protein-1alpha, the ...
Richard P Lifton, Murat Günel
exaly   +3 more sources

PTEN/PI3K/Akt/VEGF signaling and the cross talk to KRIT1, CCM2, and PDCD10 proteins in cerebral cavernous malformations

Neurosurgical Review, 2014
Cerebral cavernous malformations (CCM) are common vascular malformation of the brain and are associated with abnormal angiogenesis. Although the exact etiology and the underlying molecular mechanism are still under investigation, recent advances in the identification of the mutations in three genes and their interactions with different signaling ...
Hartmann, Christian, Zhu, Yuan, Sure, Ulrich   +2 more
openaire   +3 more sources

KRIT1 as a possible new player in melanoma aggressiveness

Archives of Biochemistry and Biophysics, 2020
Federica Finetti, Clelia Miracco, Giuseppe Valacchi   +2 more
exaly  

Cocrystal structure of the ICAP1 PTB domain in complex with a KRIT1 peptide

Acta Crystallographica Section F: Structural Biology Communications, 2013
Wei-zhi Liu, Titus J Boggon
exaly  

KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction

International Journal of Molecular Sciences, 2019
Francesco Vieceli Dalla Sega, Raffaella Mastrocola, Giorgio Aquila   +2 more
exaly