Results 31 to 40 of about 1,857 (169)

Spatial Mechano‐Signaling Regulation of GTPases through Non‐Degradative Ubiquitination

Advanced Science, Volume 10, Issue 36, December 27, 2023., 2023
An integrative ubiquitinome and proteome analysis demonstrates that the non‐degradative ubiquitination of several GTPases is regulated by mechano‐signaling. Spatial analysis reveals RAP1 ubiquitination specifically in the descending aorta, a region exposed to laminar shear stress.
Raj N. Sewduth, Paolo Carai, Tonci Ivanisevic, Mingzhen Zhang, Hyunbum Jang, Benoit Lechat, Delphi Van Haver, Francis Impens, Ruth Nussinov, Elizabeth Jones, Anna Sablina   +10 more
wiley   +1 more source

Defining bone fide effectors of RAS GTPases

BioEssays, Volume 45, Issue 9, September 2023., 2023
RAS GTPases transmit extracellular signals to multiple intracellular signalling pathways through direct interaction with effector proteins. These proteins typically employ RAS‐binding RBD domains to complex with activated GTPases, but the specificity of these interactions remains poorly explored and there remain few data describing the mechanistic ...
Matthew J. Smith
wiley   +1 more source

Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations. [PDF]

, 2015
PurposeThe phenotypic manifestations of cerebral cavernous malformation disease caused by rare PDCD10 mutations have not been systematically examined, and a mechanistic link to Rho kinase-mediated hyperpermeability, a potential therapeutic target, has ...
Akers, Amy L, Austin, Cecilia, Awad, Issam A, De Souza, Jorge Marcondes, Gallione, Carol J, Gunel, Murat, Lee, Connie, Marchuk, Douglas A, McDonald, David A, Mikati, Abdul Ghani, Min, Wang, Rebeiz, Tania, Rorrer, Autumn, Shenkar, Robert, Shi, Changbin, Stockton, Rebecca A, Zhang, Lingjiao   +16 more
core   +2 more sources

Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity. [PDF]

, 2016
Heart of Glass (HEG1), a transmembrane receptor, and Rasip1, an endothelial-specific Rap1-binding protein, are both essential for cardiovascular development.
de Kreuk, Bart-Jan, Gingras, Alexandre R, Gingras, Anne-Claude, Ginsberg, Mark H, Knight, James Dr, Liu, Jian J   +5 more
core   +2 more sources

Pediatric epilepsy surgery from 2000 to 2018: Changes in referral and surgical volumes, patient characteristics, genetic testing, and postsurgical outcomes

Epilepsia, Volume 64, Issue 9, Page 2260-2273, September 2023., 2023
Abstract Objective Neurosurgery is a safe and effective form of treatment for select children with drug‐resistant epilepsy. Still, there is concern that it remains underutilized, and that seizure freedom rates have not improved over time. We investigated referral and surgical practices, patient characteristics, and postoperative outcomes over the past ...
Maria H. Eriksson, Kirstie J. Whitaker, John Booth, Rory J. Piper, Aswin Chari, Patricia Martin Sanfilippo, Ana Perez Caballero, Lara Menzies, Amy McTague, Sophie Adler, Konrad Wagstyl, Martin M. Tisdall, J. Helen Cross, Torsten Baldeweg   +13 more
wiley   +1 more source

Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis

eLife, 2018
Endothelial cells respond to different levels of fluid shear stress through adaptations of their mechanosensitivity. Currently, we lack a good understanding of how this contributes to sculpting of the cardiovascular system.
Stefan Donat, Marta Lourenço, Alessio Paolini, Cécile Otten, Marc Renz, Salim Abdelilah-Seyfried   +5 more
doaj   +1 more source

A Novel CCM2 Gene Mutation Associated With Cerebral Cavernous Malformation

Frontiers in Neurology, 2020
Cerebral cavernous malformations (CCMs) are the second most prevalent type of vascular malformation within the central nervous system. CCMs occur in two forms—sporadic and familial—the latter of which has an autosomal dominant mode of inheritance with ...
Lipeng Yang, Jian Wu, Jing Zhang
doaj   +1 more source

Impaired retinoic acid signaling in cerebral cavernous malformations

Scientific Reports, 2023
The capillary-venous pathology cerebral cavernous malformation (CCM) is caused by loss of CCM1/Krev interaction trapped protein 1 (KRIT1), CCM2/MGC4607, or CCM3/PDCD10 in some endothelial cells.
Nastasja Grdseloff, Gwenola Boulday, Claudia J. Rödel, Cécile Otten, Daphné Raphaelle Vannier, Cécile Cardoso, Eva Faurobert, Deepika Dogra, Elisabeth Tournier-Lasserve, Salim Abdelilah-Seyfried   +9 more
doaj   +1 more source

A Case Report and Overview of Familial Cerebral Cavernous Malformation Pathogenesis in an Adult Patient [PDF]

, 2018
OBJECTIVE We present a case of a 39 year-old woman who presented with a solitary cavernous malformation hemorrhage without any other lesions, and subsequently presented several months later with a new hemorrhage from a de novo lesion.
Arul, BS, Manu K., Gooch, MD, Michael R., Khanna, Omaditya   +2 more
core   +2 more sources

Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22 [PDF]

Oncogene, 1997
Krev-1/rap1A is an evolutionarily conserved Ras-family GTPase whose cellular function remains unclear, but which has been proposed to function as a tumor suppressor gene, and may act as a Ras antagonist. To elucidate Krev-1 activity, we have used LexA-Krev-1 in a two-hybrid screen of a HeLa cell cDNA library.
I, Serebriiskii, J, Estojak, G, Sonoda, J R, Testa, E A, Golemis   +4 more
openaire   +2 more sources