Results 71 to 80 of about 1,869 (158)

Identification of a Novel ECM Remodeling Macrophage Subset in AKI to CKD Transition by Integrative Spatial and Single‐Cell Analysis

Advanced Science, Volume 11, Issue 38, October 16, 2024.
This study sheds new light on the heterogeneous roles of macrophages in the complex and cumbersome pathological process of AKI to CKD. Integrating high‐throughput spatial and single‐cell transcriptomic data, the study identifies distinct macrophage lineages, with renal resident macrophages promoting repair and monocyte‐derived ECM remodeling ...
Yi‐Lin Zhang, Tao‐Tao Tang, Bin Wang, Yi Wen, Ye Feng, Qing Yin, Wei Jiang, Yue Zhang, Zuo‐Lin Li, Min Wu, Qiu‐Li Wu, Jing Song, Steven D. Crowley, Hui‐Yao Lan, Lin‐Li Lv, Bi‐Cheng Liu   +15 more
wiley   +1 more source

Cervicovaginal specimen biomarkers for early detection of ovarian and endometrial cancer: A review

Cancer Medicine, Volume 13, Issue 14, July 2024.
Abstract Background In the last decade, technical innovations have resulted in the development of several minimally invasive diagnostic cancer tools. Within women at high risk of developing ovarian cancer (OC) or endometrial cancer (EC) due to a hereditary cancer syndrome, there is an urgent need for minimally invasive and patient‐friendly methods to ...
Kevin J. J. Kwinten, Victor A. Lemain, Joanne A. de Hullu, William P. J. Leenders, Miranda P. Steenbeek, Anne M. van Altena, Johanna M. A. Pijnenborg   +6 more
wiley   +1 more source

Genetic mutations and phenotype characteristics in peripheral vascular malformations: A systematic review

Journal of the European Academy of Dermatology and Venereology, Volume 38, Issue 7, Page 1314-1328, July 2024.
Abstract Vascular malformations (VMs) are clinically diverse with regard to the vessel type, anatomical location, tissue involvement and size. Consequently, symptoms and disease impact differ significantly. Diverse causative mutations in more and more genes are discovered and play a major role in the development of VMs.
M. L. E. Stor, S. E. R. Horbach, M. M. Lokhorst, E. Tan, S. M. Maas, C. J. M. van Noesel, C. M. A. M. van der Horst   +6 more
wiley   +1 more source

KRIT1 loss of function causes a ROS-dependent upregulation of c-Jun [PDF]

, 2014
Loss-of-function mutations in the KRIT1 gene (CCM1) have been associated with the pathogenesis of cerebral cavernous malformations (CCM), a major cerebrovascular disease.
Biasi, Fiorella, Braggion, S., De Luca, Elisa, Forni, M., Goitre, Luca, Guglielmotto, Michela, Moglia, Andrea, Retta, Saverio Francesco, Trabalzini, L., Trapani, Eliana   +9 more
core   +1 more source

Clinical pharmacology and tolerability of REC‐994, a redox‐cycling nitroxide compound, in randomized phase 1 dose‐finding studies

Pharmacology Research &Perspectives, Volume 12, Issue 3, June 2024.
Cerebral cavernous malformation (CCM) pathogenesis involves elevated reactive oxygen species (ROS) levels. REC‐994 restores ROS balance, and in double‐blind, placebo‐controlled, trials in healthy volunteers, had low potential for off‐target adverse effects and pharmacokinetics suitable for phase 2 development.
Ron Alfa, Timothy Considine, Shafique Virani, Matt Pfeiffer, Anthony Donato, Daniel Dickerson, Diana Shuster, Joel Ellis, Kristen Rushton, Helen Wei, Christopher Gibson   +10 more
wiley   +1 more source

A Tight Contact: The Expanding Application of Salicylaldehydes in Lysine‐Targeting Covalent Drugs

ChemBioChem, Volume 25, Issue 7, April 2, 2024.
Salicylaldehyde‐bearing ligands can bind the protein targets forming imines with lysine‐amino groups. This drug design improves the affinity and selectivity for specific biological targets. Given the abundance of lysine residues in proteins and the reversible covalent (RC) nature of ligand‐protein interaction, SA‐bearing ligands hold significant ...
Mattia Mason, Laura Belvisi, Luca Pignataro, Alberto Dal Corso   +3 more
wiley   +1 more source

Inherited cavernous malformations of the central nervous system: clinical and genetic features in 19 Swiss families [PDF]

, 2018
Cavernous malformations (CCMs) are benign, well-circumscribed, and mulberry-like vascular malformations that may be found in the central nervous system in up to 0.5% of the population. Cavernous malformations can be sporadic or inherited.
Andermann, F., Baumann, C., Baumgartner, R., Bonassin, F., Georgiadis, D., Graeni, C., Merlo, A., Rouleau, G., Siegel, A., Stepper, F., Sturzenegger, M., Verlaan, D.   +11 more
core  

Club cell‐specific telomere protection protein 1 (TPP1) protects against tobacco smoke‐induced lung inflammation, xenobiotic metabolic dysregulation, and injurious responses

FASEB BioAdvances, Volume 6, Issue 2, Page 53-71, February 2024.
Abstract Inhaling xenobiotics, such as tobacco smoke is a major risk factor for pulmonary diseases, e.g., COPD/emphysema, interstitial lung disease, and pre‐invasive diseases. Shelterin complex or telosome provides telomeric end protection during replication.
Thivanka Muthumalage, Chiara Goracci, Irfan Rahman   +2 more
wiley   +1 more source

Functional characterisation of a novel nucleoporin gene NUP98 in zebrafish embryo. [PDF]

, 2010
Oral PresentationINTRODUCTION: The nucleoporin gene nup98 is important for the regulation of cytoplasmic-nuclear trafficking. Frequent disruptions of NUP98 during chromosomal translocation in acute myeloid leukaemia suggest that it may play a role in ...
Fung, TK, Leung, AYH, Liang, RHS
core  

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE [PDF]

, 2018
The apical inflammatory cytokine TNF regulates numerous important biological processes including inflammation and cell death, and drives inflammatory diseases.
Adrain, Colin, Bileck, Andrea, Bolado, Alfonso, Brezinova, Jana, Burbridge, Emma, Cavadas, Miguel, Clancy, Danielle, Collis, Blanka, Gerner, Christopher, Hu, Tianyi, Martin, Seamus J, Naegele, Heike, Oikonomidi, Ioanna, Steinberg, Florian, Strisovsky, Kvido, Sullivan, Graeme, Von Kriegsheim, Alex   +16 more
core   +2 more sources