Results 111 to 120 of about 723,697 (239)

Loss of the Krüppel-like factor 4 tumor suppressor is associated with epithelial-mesenchymal transition in colorectal cancer. [PDF]

J Cancer Metastasis Treat, 2019
Colorectal cancer (CRC) is the third leading cancer-related cause of death due to its propensity to metastasize. Epithelial-mesenchymal transition (EMT) is a multistep process important for invasion and metastasis of CRC.
Agbo KC, Huang JZ, Ghaleb AM, Williams JL, Shroyer KR, Bialkowska AB, Yang VW.   +6 more
europepmc   +2 more sources

SETD5 regulates the OGT-catalyzed O-GlcNAcylation of RNA polymerase II, which is involved in the stemness of colorectal cancer cells

Scientific Reports, 2023
The dosage-dependent recruitment of RNA polymerase II (Pol II) at the promoters of genes related to neurodevelopment and stem cell maintenance is required for transcription by the fine-tuned expression of SET-domain-containing protein 5 (SETD5). Pol II O-
Hye In Cho, Sora Jo, Min Seong Kim, Han Byeol Kim, Xingzhe Liu, Yanhua Xuan, Jin Won Cho, Yeun Kyu Jang   +7 more
doaj   +1 more source

MiR‐1 Is Regulated by Hydrogen Peroxide via MAPK and Limits Cell Migration and Invasion

Environmental Toxicology, EarlyView.
ABSTRACT MicroRNA‐1 (miR‐1) is a conserved microRNA that is highly expressed in skeletal and cardiac muscle tissues. Moreover, miR‐1 regulates genes and has critical roles in cell migration and invasion. Downregulation of miR‐1 has been found in many pathologies of numerous organs, including the lungs.
Maricica Pacurari, Irmanecia Cox, Ibrahim Farah   +2 more
wiley   +1 more source

Efficient Identification of Butterfly Sparse Matrix Factorizations [PDF]

SIAM Journal on Mathematics of Data Science, Society for Industrial and Applied Mathematics, In press, 2021
Fast transforms correspond to factorizations of the form $\mathbf{Z} = \mathbf{X}^{(1)} \ldots \mathbf{X}^{(J)}$, where each factor $ \mathbf{X}^{(\ell)}$ is sparse and possibly structured. This paper investigates essential uniqueness of such factorizations, i.e., uniqueness up to unavoidable scaling ambiguities.
arxiv  

Single‐cell spatial transcriptomic sequencing and machine learning models uncover molecular mechanisms and diagnostic biomarkers of Peyronie's disease formation in rats

VIEW, EarlyView.
Peyronie's disease (PD) is a common male reproductive system disorder. The exact etiology of PD remains unclear. This study aimed to investigate molecular and cellular changes in PD using single‐cell spatial transcriptomics. Abstract Peyronie's disease (PD), commonly known as penile induration, is a prevalent male reproductive system disorder with ...
Keyuan Lou, Qiancheng Mao, Junpeng Chi, Jiankun Zhang, Hao Guo, Jitao Wu, Yuanshan Cui   +6 more
wiley   +1 more source

MiR-135b-5p promotes viability, proliferation, migration and invasion of gastric cancer cells by targeting Krüppel-like factor 4 (KLF4)

Archives of medical science : AMS, 2019
Introduction The expression of MiR-135b-5p was up-regulated while Krüppel-like factor 4 (KLF4) expression was extremely low in human gastric carcinoma (GC) tissues.
Zhi Chen, Yongjian Gao, Shuohui Gao, De-feng Song, Ye Feng   +4 more
semanticscholar   +1 more source

Unique prime factorization for infinite tensor product factors [PDF]

arXiv, 2017
In this article, we investigate a unique prime factorization property for infinite tensor product factors. We provide several examples of type II and III factors which satisfy this property, including all free product factors with diffuse free product components.
arxiv  

Different parts of the mussel Gigantidas haimaensis holobiont responded differently to deep‐sea sampling stress

Integrative Zoology, EarlyView.
Symbiotic gill and nonsymbiotic mantle of mussel Gigantidas haimaensis responded differently to deep‐sea sampling stress caused by acute environmental changes. Sharply increased transcription factors potentially play key roles in initiating the response of sampled deep‐sea macrobenthos to the sampling stress.
Guoyong YAN, Tong WEI, Yi LAN, Ting XU, Peiyuan QIAN   +4 more
wiley   +1 more source

miR-7-5p regulates the proliferation and migration of colorectal cancer cells by negatively regulating the expression of Krüppel-like factor 4

Oncology Letters, 2019
Previous studies have demonstrated that microRNA-7-5p (miR-7-5p) functions as a tumor suppressor in certain types of human cancer. However, the role of miR-7-5p in colorectal cancer (CRC) remains to be investigated.
Mingjun Dong, Yangyang Xie, Yidong Xu
semanticscholar   +1 more source

Kruppel-like Factor 4 Abrogates Myocardin-induced Activation of Smooth Muscle Gene Expression [PDF]

Journal of Biological Chemistry, 2005
Platelet-derived growth factor BB (PDGF-BB) has been shown to be an extremely potent negative regulator of smooth muscle cell (SMC) differentiation. Moreover, previous studies have demonstrated that the Kruppel-like transcription factor (KLF) 4 potently represses the expression of multiple SMC genes.
Oliver G. McDonald, Yan Liu, Mark H. Hoofnagle, Sanjay Sinha, Yueting Shang, Gary K. Owens   +5 more
openaire   +3 more sources