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SOX2 in development and cancer biology
Seminars in Cancer Biology, 2020 The transcription factor SOX2 is essential for embryonic development and plays a crucial role in maintaining the stemness of embryonic cells and various adult stem cell populations. On the other hand, dysregulation of SOX2 expression is associated with a multitude of cancer types and it has been shown that SOX2 positively affects cancer cell traits ...
Daniel Novak +2 more
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Molecular Oncology, 2021 The involvement of LncRNA SOX2‐overlapping transcript (SOX2‐OT), SOX2, and GLI‐1 transcription factors in cancer has been well documented. Nonetheless, it is still unknown whether co‐expressed SOX2‐OT/SOX2 or SOX2‐OT/SOX2/GLI‐1 axes are epigenetically ...
Abril Marcela Herrera-Solorio +2 more
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Specificity and application of SOX2 antibody
Poultry Science, 2020 Sox2 is known to play an important role in maintaining the totipotency and self-renewal of embryonic stem cells. The purpose of this study was to prepare an anti-chicken Sox2 polyclonal antibody using prokaryotic expression techniques, to evaluate its ...
Longqin Wei +11 more
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CARM1 mediates modulation of Sox2. [PDF]
PLoS ONE, 2011 Sox2 is a key component of the transcription factor network that maintains the pluripotent state of embryonic stem cells (ESCs). Sox2 is regulated by multiple post-translational modifications, including ubiquitination, sumoylation, acetylation and ...
Hai-yong Zhao +4 more
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LIF signaling pathway regulates the heterogeneous Sox2 transcriptional dynamics in mESCs [PDF]
Scientific ReportsThe LIF signaling pathway is crucial for maintaining self-renewal and pluripotency in mESCs through regulation of factors like Sox2, yet its direct impact on Sox2 transcriptional dynamics remains elusive.
Gaochen Jin +4 more
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An early Sox2-dependent gene expression programme required for hippocampal dentate gyrus development [PDF]
Open Biology, 2021 The hippocampus is a brain area central for cognition. Mutations in the human SOX2 transcription factor cause neurodevelopmental defects, leading to intellectual disability and seizures, together with hippocampal dysplasia. We generated an allelic series
Sara Mercurio +7 more
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High SOX2 expression as an indicator of the potential involvement of cancer stem cells in the development of cervical cancer among females with HPV infection [PDF]
CellR4, 2021 Objective: Cervical cancer ranks fourth for both incidence and mortality among females. Human papillomavirus (HPV) infection plays an important role in the pathophysiology of cervical cancer.
E. Kldiashvili +2 more
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A predicted two to tango interaction between MUC1 and SOX2: a unique opportunity to target cancer stem cells [PDF]
World Cancer Research Journal, 2022 Objective: Cancer stem cell (CSC) genes are emerging as cancer therapeutic targets. MUC1 is a cell surface-associated glycoprotein that is aberrantly over‐expressed in >60% of human cancers including breast cancer.
A. Dutta, S. Paul
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SOX2 inhibits LLGL2 polarity protein in esophageal squamous cell carcinoma via miRNA-142-3p
Cancer Biology & Therapy, 2022 Elevated SOX2 protein levels correspond to the poor prognosis of patients with esophageal squamous cell carcinoma (ESCC). Poor prognosis is closely correlated with the loss or disruption of cellular polarity; however, the relationships between SOX2 ...
Shihui Zhang +15 more
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Long Live Sox2: Sox2 Lasts a Lifetime [PDF]
Cell Stem Cell, 2011 Sox2 is a key transcription factor required for the maintenance of pluripotency in embryonic cells and morphogenesis of several epithelia. In this issue of Cell Stem Cell, Arnold et al. (2011) demonstrate that Sox2 marks long-lived adult stem cells to ensure homeostasis in a broad range of adult tissues.
Driessens, Grégory, Blanpain, Cédric
openaire +3 more sources