Molecular Oncology, 2021 The involvement of LncRNA SOX2‐overlapping transcript (SOX2‐OT), SOX2, and GLI‐1 transcription factors in cancer has been well documented. Nonetheless, it is still unknown whether co‐expressed SOX2‐OT/SOX2 or SOX2‐OT/SOX2/GLI‐1 axes are epigenetically ...
Abril Herrera Solorio +2 more
exaly +2 more sources
LIF signaling pathway regulates the heterogeneous Sox2 transcriptional dynamics in mESCs [PDF]
Scientific ReportsThe LIF signaling pathway is crucial for maintaining self-renewal and pluripotency in mESCs through regulation of factors like Sox2, yet its direct impact on Sox2 transcriptional dynamics remains elusive.
Gaochen Jin +4 more
doaj +2 more sources
An early Sox2-dependent gene expression programme required for hippocampal dentate gyrus development [PDF]
Open Biology, 2021 The hippocampus is a brain area central for cognition. Mutations in the human SOX2 transcription factor cause neurodevelopmental defects, leading to intellectual disability and seizures, together with hippocampal dysplasia. We generated an allelic series
Sara Mercurio +7 more
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High SOX2 expression as an indicator of the potential involvement of cancer stem cells in the development of cervical cancer among females with HPV infection [PDF]
CellR4, 2021 Objective: Cervical cancer ranks fourth for both incidence and mortality among females. Human papillomavirus (HPV) infection plays an important role in the pathophysiology of cervical cancer.
E. Kldiashvili +2 more
doaj +1 more source
A predicted two to tango interaction between MUC1 and SOX2: a unique opportunity to target cancer stem cells [PDF]
World Cancer Research Journal, 2022 Objective: Cancer stem cell (CSC) genes are emerging as cancer therapeutic targets. MUC1 is a cell surface-associated glycoprotein that is aberrantly over‐expressed in >60% of human cancers including breast cancer.
A. Dutta, S. Paul
doaj +1 more source
Comparative characteristic of lung cancer stem-like cells generated in vitro under different culture conditions [PDF]
The Ukrainian Biochemical Journal, 2021 Cancer stem cells (CSCs) play an important role in resistance to cancer treatment and recurrence developing. The aim of this study was to obtain cell culture of MOR line non-small cell lung cancer cells enriched in CSCs and to investigate its functional ...
O. V. Skachkova +4 more
doaj +1 more source
SOX2 inhibits LLGL2 polarity protein in esophageal squamous cell carcinoma via miRNA-142-3p
Cancer Biology & Therapy, 2022 Elevated SOX2 protein levels correspond to the poor prognosis of patients with esophageal squamous cell carcinoma (ESCC). Poor prognosis is closely correlated with the loss or disruption of cellular polarity; however, the relationships between SOX2 ...
Shihui Zhang +15 more
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BIOSCAFFOLD FROM MOUSE EMBRYONIC FIBROBLAST MAINTAINS THE PLURIPOTENCY OF MOUSE EMBRYONIC STEM CELLS
Journal of Stem Cell Research and Tissue Engineering, 2023 Cell culture using a 3D method provides Various cell culture strategies have been developed using synthetic or biological materials; most existing publications use many reagents. Bioscaffold from mouse embryonic fibroblast (MEF) enhances cell attachment,
Rifqah Mifthahul Jannah +2 more
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Construction of recombinant sox2-encoding plasmids that regulate pluripotency of breast cancer stem cells from indonesian patient [PDF]
Pharmaciana, 2019 A therapy development with recombinant protein is a new and potential innovation to destroy cancer stem cells (CSCs). Various ways of killing CSCs include the provision of polyvalent anti-protein antibodies that code pluripotency.
Hanifah Rahmi +3 more
doaj +1 more source
Indonesian Journal of Cancer, 2021 Background: CD133 overexpression can increase cell proliferation, migration, and epithelialmesenchymal transition that promotes metastasis. CD133 expression is induced by hypoxiainduced factor (HIF) which requires SOX2 binding in the promoter region ...
Sutrisno, Dyah Fauziah, Gondo Mastutik
doaj +1 more source