Results 1 to 10 of about 43,496 (227)
Prognostic value of NOTCH1 and OCT4 in gastric carcinoma
Indian Journal of Pathology and Microbiology, 2022 Background: NOTCH1 pathway activation has been recently described to be a key player in gastric carcinogenesis, enhance the survival and proliferation of cancer stem cells (CSCs) and mediate chemoresistance in several malignancies.
Doaa Abdelaziz Ibrahim +3 more
doaj +3 more sources
Journal of the Egyptian National Cancer Institute, 2019 Background Octamer-binding transcription factor 4 (Oct4) is a transcription factor that has an important role in stem cell differentiation and self-renewal. Oct4 has also been implicated in tumorigenicity of different cancers. This study aimed to analyze
Dina El-Guindy +2 more
exaly +3 more sources
Oct4 is required for primordial germ cell survival [PDF]
EMBO Reports, 2004 Previous studies have shown that Oct4 has an essential role in maintaining pluripotency of cells of the inner cell mass (ICM) and embryonic stem cells. However, Oct4 null homozygous embryos die around the time of implantation, thus precluding further analysis of gene function during development.
Hilda Lomeli +2 more
exaly +3 more sources
Role of Oct4 in the early embryo development
Cell Regeneration, 2014 Oct4 is a key component of the pluripotency regulatory network, and its reciprocal interaction with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem cells (ESCs) or their differentiation into trophoblast.
Guangming Wu, Hans R Schöler
doaj +3 more sources
Clinical Cancer Research, 2004 AbstractPurpose: OCT4 (POU5F1, OCT3) immunostaining highlights pluripotent cells (embryonal carcinoma and seminoma) in primary testicular germ cell tumors, but its relative usefulness in diagnosing intratubular germ cell neoplasia, unclassified (IGCNU) is not well established.
Timothy D. Jones +3 more
openaire +3 more sources
Porcine OCT4 reporter system as a tool for monitoring pluripotency states
Journal of Animal Reproduction and Biotechnology, 2021 Pluripotent stem cells could self-renew and differentiate into various cells. In particular, porcine pluripotent stem cells are useful for preclinical therapy, transgenic animals, and agricultural usage. These stem cells have naïve and primed pluripotent
Seung-Hun Kim, Chang-Kyu Lee
doaj +1 more source
BIOSCAFFOLD FROM MOUSE EMBRYONIC FIBROBLAST MAINTAINS THE PLURIPOTENCY OF MOUSE EMBRYONIC STEM CELLS
Journal of Stem Cell Research and Tissue Engineering, 2023 Cell culture using a 3D method provides Various cell culture strategies have been developed using synthetic or biological materials; most existing publications use many reagents. Bioscaffold from mouse embryonic fibroblast (MEF) enhances cell attachment,
Rifqah Mifthahul Jannah +2 more
doaj +1 more source
Molecular Characterization of Differentiated-Resistance MSC Subclones by Single-Cell Transcriptomes
Frontiers in Cell and Developmental Biology, 2022 Background: The mechanism of tumorigenicity potentially evolved in mesenchymal stem cells (MSCs) remains elusive, resulting in inconsistent clinical application efficacy.
Andres Stucky +16 more
doaj +1 more source
Rambam Maimonides Medical Journal, 2021 Objectives: To study the correlation between the putative cancer stem cell (CSC) markers aldehyde dehydrogenase 1 (ALDH1), cluster of differentiation 44 (CD44), sex-determining region Y-box 2 (SOX2), and octamer-binding protein 4 (OCT4) and human ...
Prasanth Thankappan +5 more
doaj +1 more source
Epigenetic silencing of Oct4 by a complex containing SUV39H1 and Oct4 pseudogene lncRNA [PDF]
Nature Communications, 2015 AbstractPseudogene-derived, long non-coding RNAs (lncRNAs) act as epigenetic regulators of gene expression. Here we present a panel of new mouseOct4pseudogenes and demonstrate that the X-linkedOct4pseudogeneOct4P4critically impacts mouse embryonic stem cells (mESCs) self-renewal.
Scarola, Michele +8 more
openaire +5 more sources