Results 1 to 10 of about 75,024 (200)
Human papillomavirus E7 binds Oct4 and regulates its activity in HPV-associated cervical cancers. [PDF]
PLoS Pathogens, 2020 Octamer binding transcription factor-4 (Oct4), is highly expressed in stem cells and has indispensable roles in pluripotency and cellular reprogramming. In contrast to other factors used for cellular reprogramming, a role for Oct4 outside embryonic stem ...
Theofano Panayiotou +5 more
doaj +2 more sources
Journal of the Egyptian National Cancer Institute, 2019 Background Octamer-binding transcription factor 4 (Oct4) is a transcription factor that has an important role in stem cell differentiation and self-renewal. Oct4 has also been implicated in tumorigenicity of different cancers. This study aimed to analyze
Dina M El-Guindy +2 more
exaly +3 more sources
Prognostic value of NOTCH1 and OCT4 in gastric carcinoma
Indian Journal of Pathology and Microbiology, 2022 Background: NOTCH1 pathway activation has been recently described to be a key player in gastric carcinogenesis, enhance the survival and proliferation of cancer stem cells (CSCs) and mediate chemoresistance in several malignancies.
Doaa Abdelaziz Ibrahim +3 more
doaj +1 more source
Porcine OCT4 reporter system as a tool for monitoring pluripotency states
Journal of Animal Reproduction and Biotechnology, 2021 Pluripotent stem cells could self-renew and differentiate into various cells. In particular, porcine pluripotent stem cells are useful for preclinical therapy, transgenic animals, and agricultural usage. These stem cells have naïve and primed pluripotent
Seung-Hun Kim, Chang-Kyu Lee
doaj +1 more source
BIOSCAFFOLD FROM MOUSE EMBRYONIC FIBROBLAST MAINTAINS THE PLURIPOTENCY OF MOUSE EMBRYONIC STEM CELLS
Journal of Stem Cell Research and Tissue Engineering, 2023 Cell culture using a 3D method provides Various cell culture strategies have been developed using synthetic or biological materials; most existing publications use many reagents. Bioscaffold from mouse embryonic fibroblast (MEF) enhances cell attachment,
Rifqah Mifthahul Jannah +2 more
doaj +1 more source
Loss of Pten causes tumor initiation following differentiation of murine pluripotent stem cells due to failed repression of Nanog. [PDF]
, 2011 Pluripotent stem cells (PSCs) hold significant promise in regenerative medicine due to their unlimited capacity for self-renewal and potential to differentiate into every cell type in the body. One major barrier to the use of PSCs is their potential risk
Banerjee, Utpal +8 more
core +11 more sources
Molecular Characterization of Differentiated-Resistance MSC Subclones by Single-Cell Transcriptomes
Frontiers in Cell and Developmental Biology, 2022 Background: The mechanism of tumorigenicity potentially evolved in mesenchymal stem cells (MSCs) remains elusive, resulting in inconsistent clinical application efficacy.
Andres Stucky +16 more
doaj +1 more source
Expression of OCT4 isoforms is reduced in primary colorectal cancer
Frontiers in Oncology, 2023 IntroductionColorectal cancer (CRC) is one of the most common types of cancer worldwide. The carcinogenesis of CRC is indeed complex, and there are many different mechanisms and pathways that contribute to the development of malignancy and the ...
Eva Turyova +11 more
doaj +1 more source
The Regulatory Effect of lncRNA PSORS1C3 on Different Variants of OCT4 in non-Pluripotent Cells [PDF]
Journal of Cell and Molecular Research, 2019 OCT4 is the major regulator of pluripotency in embryonic stem cells and its association with tumorigenesis, cellular stress response, and homeostatic multifactorial diseases have been recently reported.
Fatemeh Mirzadeh azad +2 more
doaj +1 more source
Rambam Maimonides Medical Journal, 2021 Objectives: To study the correlation between the putative cancer stem cell (CSC) markers aldehyde dehydrogenase 1 (ALDH1), cluster of differentiation 44 (CD44), sex-determining region Y-box 2 (SOX2), and octamer-binding protein 4 (OCT4) and human ...
Prasanth Thankappan +5 more
doaj +1 more source