Results 11 to 20 of about 43,496 (227)
Molecular & Cellular Oncology, 2020 Colorectal cancer (CRC) is one of the most important malignancies and causes of cancer-related deaths worldwide. Cancer stem cell markers identification could be helpful to acquire important prognostic information and develop new treatment regimens. This
Raheleh Roudi +5 more
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Development: Sketch for a Theory of Oct4 [PDF]
Current Biology, 2013 How is it that Oct4, a transcription factor that controls pluripotency in stem cells, also controls lineage specification? A recent study investigating common Oct4 targets in vertebrate species indicates an evolutionarily conserved role in mediating cell adhesion. This finding may help decipher Oct4's versatility in governing stem cell behaviors.
Wagner, Ryan T., Zwaka, Thomas P.
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Expression of Oct4 Protein in Astrocytic Tumours-Histopathologic and Immunohistochemical Study [PDF]
Journal of Clinical and Diagnostic Research, 2018 Introduction: The majority of gliomas in adults are resistant to therapy. Therapy resistance has been attributed to the presence of cancer stem cells (CSCs).
Menar M Al-Sayed Ayoub +3 more
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Of Mice and Snakes: A Tail of Oct4 [PDF]
Developmental Cell, 2016 The vertebrate axial skeleton comprises regions of specialized vertebrae, which vary in length between lineages. Aires et al. (2016) uncover a key role for Oct4 in determining trunk length in mice. Additionally, a heterochronic shift in Oct4 expression may underlie the extreme elongation of the trunk in snakes.
Natalia A, Shylo, Scott D, Weatherbee
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The heptamer sgRNA targeting the human OCT4 mRNA can upregulate the OCT4 expression
Biochemistry and Biophysics Reports, 2021 TRUE gene silencing is one of the gene suppression technologies. This technology exploits the enzymatic property of the tRNA 3' processing endoribonuclease tRNase ZL, which is that it can cleave a target RNA under the direction of a small guide RNA (sgRNA). We have been working on the development of therapeutic sgRNAs for hematological malignancies. In
Tadasuke Nozaki +7 more
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Cancer Biology & Medicine, 2020 Objective: Cancer stem cell is one of the important causes of tumorigenesis as well as a drug target in the treatment of malignant tumor. However, at present, there is no immune vaccine targeting these cells. Octamer-binding transcription factor 4 (OCT4),
Tingting Chen +12 more
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Expression of OCT4 isoforms is reduced in primary colorectal cancer
Frontiers in Oncology, 2023 IntroductionColorectal cancer (CRC) is one of the most common types of cancer worldwide. The carcinogenesis of CRC is indeed complex, and there are many different mechanisms and pathways that contribute to the development of malignancy and the ...
Eva Turyova +11 more
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Phosphorylation regulates human OCT4 [PDF]
Proceedings of the National Academy of Sciences, 2012 The transcription factor OCT4 is fundamental to maintaining pluripotency and self-renewal. To better understand protein-level regulation of OCT4, we applied liquid chromatography–MS to identify 14 localized sites of phosphorylation, 11 of which were previously unknown.
Justin, Brumbaugh +7 more
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The Regulatory Effect of lncRNA PSORS1C3 on Different Variants of OCT4 in non-Pluripotent Cells [PDF]
Journal of Cell and Molecular Research, 2019 OCT4 is the major regulator of pluripotency in embryonic stem cells and its association with tumorigenesis, cellular stress response, and homeostatic multifactorial diseases have been recently reported.
Fatemeh Mirzadeh azad +2 more
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Cell Stem Cell, 2010 The transcription factor Oct4 plays a central role in controlling the undifferentiated state of embryonic and induced pluripotent stem cells. Two complementary papers in this issue of Cell Stem Cell describe the extended network of proteins that interact with Oct4. Together, these studies broaden our understanding of the control of pluripotency.
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