Results 11 to 20 of about 75,125 (295)
Clinical Cancer Research, 2004 AbstractPurpose: OCT4 (POU5F1, OCT3) immunostaining highlights pluripotent cells (embryonal carcinoma and seminoma) in primary testicular germ cell tumors, but its relative usefulness in diagnosing intratubular germ cell neoplasia, unclassified (IGCNU) is not well established.
Timothy D. Jones +3 more
+6 more sources
Role of Oct4 in the early embryo development
Cell Regeneration, 2014 Oct4 is a key component of the pluripotency regulatory network, and its reciprocal interaction with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem cells (ESCs) or their differentiation into trophoblast.
Guangming Wu, Hans R Schöler
doaj +3 more sources
Oct4 transforming melanoma [PDF]
Pigment Cell & Melanoma Research, 2013 Robert Ballotti
openalex +2 more sources
Epigenetic silencing of Oct4 by a complex containing SUV39H1 and Oct4 pseudogene lncRNA [PDF]
Nature Communications, 2015 AbstractPseudogene-derived, long non-coding RNAs (lncRNAs) act as epigenetic regulators of gene expression. Here we present a panel of new mouseOct4pseudogenes and demonstrate that the X-linkedOct4pseudogeneOct4P4critically impacts mouse embryonic stem cells (mESCs) self-renewal.
Scarola, Michele +8 more
openaire +5 more sources
Molecular & Cellular Oncology, 2020 Colorectal cancer (CRC) is one of the most important malignancies and causes of cancer-related deaths worldwide. Cancer stem cell markers identification could be helpful to acquire important prognostic information and develop new treatment regimens. This
Raheleh Roudi +5 more
doaj +1 more source
Development: Sketch for a Theory of Oct4 [PDF]
Current Biology, 2013 How is it that Oct4, a transcription factor that controls pluripotency in stem cells, also controls lineage specification? A recent study investigating common Oct4 targets in vertebrate species indicates an evolutionarily conserved role in mediating cell adhesion. This finding may help decipher Oct4's versatility in governing stem cell behaviors.
Wagner, Ryan T., Zwaka, Thomas P.
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Of Mice and Snakes: A Tail of Oct4 [PDF]
Developmental Cell, 2016 The vertebrate axial skeleton comprises regions of specialized vertebrae, which vary in length between lineages. Aires et al. (2016) uncover a key role for Oct4 in determining trunk length in mice. Additionally, a heterochronic shift in Oct4 expression may underlie the extreme elongation of the trunk in snakes.
Natalia A, Shylo, Scott D, Weatherbee
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The heptamer sgRNA targeting the human OCT4 mRNA can upregulate the OCT4 expression
Biochemistry and Biophysics Reports, 2021 TRUE gene silencing is one of the gene suppression technologies. This technology exploits the enzymatic property of the tRNA 3' processing endoribonuclease tRNase ZL, which is that it can cleave a target RNA under the direction of a small guide RNA (sgRNA). We have been working on the development of therapeutic sgRNAs for hematological malignancies. In
Tadasuke Nozaki +7 more
openaire +3 more sources
PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation. [PDF]
, 2018 Germ cell tumors (GCTs) are a heterogeneous group of tumors occurring in gonadal and extragonadal locations. GCTs are hypothesized to arise from primordial germ cells (PGCs), which fail to differentiate.
Chen, Di +4 more
core +9 more sources
Phosphorylation regulates human OCT4 [PDF]
Proceedings of the National Academy of Sciences, 2012 The transcription factor OCT4 is fundamental to maintaining pluripotency and self-renewal. To better understand protein-level regulation of OCT4, we applied liquid chromatography–MS to identify 14 localized sites of phosphorylation, 11 of which were previously unknown.
Justin, Brumbaugh +7 more
openaire +2 more sources