Results 11 to 20 of about 54,485 (283)
Role of Oct4 in the early embryo development
Cell Regeneration, 2014 Oct4 is a key component of the pluripotency regulatory network, and its reciprocal interaction with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem cells (ESCs) or their differentiation into trophoblast.
Guangming Wu, Hans R Schöler
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Cell Stem Cell, 2010 The transcription factor Oct4 plays a central role in controlling the undifferentiated state of embryonic and induced pluripotent stem cells. Two complementary papers in this issue of Cell Stem Cell describe the extended network of proteins that interact
Lemischka, Ihor R., Ihor R. Lemischka
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Prognostic value of NOTCH1 and OCT4 in gastric carcinoma
Indian Journal of Pathology and Microbiology, 2022 Background: NOTCH1 pathway activation has been recently described to be a key player in gastric carcinogenesis, enhance the survival and proliferation of cancer stem cells (CSCs) and mediate chemoresistance in several malignancies.
Doaa Abdelaziz Ibrahim +3 more
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Journal of the Egyptian National Cancer Institute, 2019 Background Octamer-binding transcription factor 4 (Oct4) is a transcription factor that has an important role in stem cell differentiation and self-renewal. Oct4 has also been implicated in tumorigenicity of different cancers. This study aimed to analyze
Muhammad Tarek Abdel Ghafar +2 more
exaly +3 more sources
Interaction between MicroRNAs and OCT4
Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2015 Octamer-binding transcription factor 4 (OCT4) belongs to the POU-homeodomain family of transcription factors and binds to an octamer motif, ATGCAAAT.
Chen CHEN +3 more
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PIAS Proteins as Repressors of Oct4 Function
Journal of Molecular Biology, 2007 The POU domain transcription factor Oct4 plays essential functions in the maintenance of pluripotent embryonic and germ cells of mammals. Molecular mechanisms of Oct4 action remain poorly understood. To isolate modulators of Oct4 activity, we performed a
Tolkunova, E. +5 more
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Stem Cell Reports, 2018 Summary: The protein level of OCT4, a core pluripotency transcription factor, is vital for embryonic stem cell (ESC) maintenance, differentiation, and somatic cell reprogramming.
Shuang Li +11 more
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Oct4 Gene Expression in Primary Colorectal Cancer Promotes Liver Metastasis
Stem Cells International, 2019 Purpose. The Oct4 gene plays an important role in undifferentiated embryonic stem cells and regulates stem cell pluripotency. The aim of this study was to examine the relationship between Oct4 expression and liver metastasis of colorectal cancer (CRC) in
Shiki Fujino, Norikatsu Miyoshi
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Stem Cell Research, 2017 The development of human induced pluripotent stem cells (iPSCs) holds great promise for regenerative medicine. However the iPSC induction efficiency is still very low and with lengthy reprogramming process.
Ling Wang +6 more
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Clinical Cancer Research, 2004 AbstractPurpose: OCT4 (POU5F1, OCT3) immunostaining highlights pluripotent cells (embryonal carcinoma and seminoma) in primary testicular germ cell tumors, but its relative usefulness in diagnosing intratubular germ cell neoplasia, unclassified (IGCNU) is not well established.
Timothy D. Jones +3 more
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