Investigating the functionality of an OCT4-short response element in human induced pluripotent stem cells. [PDF]
, 2016 Pluripotent stem cells offer great therapeutic promise for personalized treatment platforms for numerous injuries, disorders, and diseases. Octamer-binding transcription factor 4 (OCT4) is a key regulatory gene maintaining pluripotency and self-renewal ...
Awe, Jason P +9 more
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Upregulation of long noncoding RNA MIAT in aggressive form of chronic lymphocytic leukemias. [PDF]
, 2016 Long noncoding RNAs (lncRNAs) are non-proten-coding transcripts of more than 200 nucleotides generated by RNA polymerase II and their expressions are tightly regulated in cell type specific- and/or cellular differential stage specific- manner.
Croce, Carlo M +6 more
core +5 more sources
Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication. [PDF]
, 2016 The transcription factor Yin Yang 1 (YY1) is frequently overexpressed in cancerous tissues compared to normal tissues and has regulatory roles in cell proliferation, cell viability, epithelial-mesenchymal transition, metastasis and drug/immune resistance.
Bonavida, Benjamin +2 more
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Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation [PDF]
, 2020 Embryonic Stem Cell (ESC) differentiation requires complex cell signalling network dynamics, although the key molecular events remain poorly understood.
Budzyk, Manon +10 more
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Expression of Oct4 Protein in Astrocytic Tumours-Histopathologic and Immunohistochemical Study [PDF]
Journal of Clinical and Diagnostic Research, 2018 Introduction: The majority of gliomas in adults are resistant to therapy. Therapy resistance has been attributed to the presence of cancer stem cells (CSCs).
Menar M Al-Sayed Ayoub +3 more
doaj +1 more source
Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [PDF]
, 2006 The POU domain transcription factor OCT4 is a key regulator of pluripotency in the early mammalian embryo and is highly expressed in the inner cell mass of the blastocyst. Consistent with its essential role in maintaining pluripotency, Oct4 expression is
Adjaye, J. +8 more
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Quantitative profiling of selective Sox/POU pairing on hundreds of sequences in parallel by Coop-seq [PDF]
, 2016 © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. Cooperative binding of transcription factors is known to be important in the regulation of gene expression programs conferring cellular identities.
Chang, Yiming K +8 more
core +3 more sources
Acoustic Tweezing Cytometry Induces Rapid Initiation of Human Embryonic Stem Cell Differentiation. [PDF]
, 2018 Mechanical forces play critical roles in influencing human embryonic stem cell (hESC) fate. However, it remains largely uncharacterized how local mechanical forces influence hESC behavior in vitro.
Deng, Cheri X +8 more
core +2 more sources
Cell Stem Cell, 2010 The transcription factor Oct4 plays a central role in controlling the undifferentiated state of embryonic and induced pluripotent stem cells. Two complementary papers in this issue of Cell Stem Cell describe the extended network of proteins that interact with Oct4. Together, these studies broaden our understanding of the control of pluripotency.
openaire +2 more sources
Cancer Biology & Medicine, 2020 Objective: Cancer stem cell is one of the important causes of tumorigenesis as well as a drug target in the treatment of malignant tumor. However, at present, there is no immune vaccine targeting these cells. Octamer-binding transcription factor 4 (OCT4),
Tingting Chen +12 more
doaj +1 more source