Results 21 to 30 of about 54,485 (283)
Porcine OCT4 reporter system as a tool for monitoring pluripotency states
Journal of Animal Reproduction and Biotechnology, 2021 Pluripotent stem cells could self-renew and differentiate into various cells. In particular, porcine pluripotent stem cells are useful for preclinical therapy, transgenic animals, and agricultural usage. These stem cells have naïve and primed pluripotent
Seung-Hun Kim, Chang-Kyu Lee
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BIOSCAFFOLD FROM MOUSE EMBRYONIC FIBROBLAST MAINTAINS THE PLURIPOTENCY OF MOUSE EMBRYONIC STEM CELLS
Journal of Stem Cell Research and Tissue Engineering, 2023 Cell culture using a 3D method provides Various cell culture strategies have been developed using synthetic or biological materials; most existing publications use many reagents. Bioscaffold from mouse embryonic fibroblast (MEF) enhances cell attachment,
Rifqah Mifthahul Jannah +2 more
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Chemical Screening Identifies Danofloxacin as a Self-Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1-Mediated Deacetylation of Tert and Prdm10. [PDF]
Adv Sci (Weinh)This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Zhang Y +8 more
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Molecular Characterization of Differentiated-Resistance MSC Subclones by Single-Cell Transcriptomes
Frontiers in Cell and Developmental Biology, 2022 Background: The mechanism of tumorigenicity potentially evolved in mesenchymal stem cells (MSCs) remains elusive, resulting in inconsistent clinical application efficacy.
Andres Stucky +16 more
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Rambam Maimonides Medical Journal, 2021 Objectives: To study the correlation between the putative cancer stem cell (CSC) markers aldehyde dehydrogenase 1 (ALDH1), cluster of differentiation 44 (CD44), sex-determining region Y-box 2 (SOX2), and octamer-binding protein 4 (OCT4) and human ...
Prasanth Thankappan +5 more
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Epigenetic silencing of Oct4 by a complex containing SUV39H1 and Oct4 pseudogene lncRNA [PDF]
Nature Communications, 2015 AbstractPseudogene-derived, long non-coding RNAs (lncRNAs) act as epigenetic regulators of gene expression. Here we present a panel of new mouseOct4pseudogenes and demonstrate that the X-linkedOct4pseudogeneOct4P4critically impacts mouse embryonic stem cells (mESCs) self-renewal.
Scarola, Michele +8 more
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Molecular & Cellular Oncology, 2020 Colorectal cancer (CRC) is one of the most important malignancies and causes of cancer-related deaths worldwide. Cancer stem cell markers identification could be helpful to acquire important prognostic information and develop new treatment regimens. This
Raheleh Roudi +5 more
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Development: Sketch for a Theory of Oct4 [PDF]
Current Biology, 2013 How is it that Oct4, a transcription factor that controls pluripotency in stem cells, also controls lineage specification? A recent study investigating common Oct4 targets in vertebrate species indicates an evolutionarily conserved role in mediating cell adhesion. This finding may help decipher Oct4's versatility in governing stem cell behaviors.
Wagner, Ryan T., Zwaka, Thomas P.
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Of Mice and Snakes: A Tail of Oct4 [PDF]
Developmental Cell, 2016 The vertebrate axial skeleton comprises regions of specialized vertebrae, which vary in length between lineages. Aires et al. (2016) uncover a key role for Oct4 in determining trunk length in mice. Additionally, a heterochronic shift in Oct4 expression may underlie the extreme elongation of the trunk in snakes.
Natalia A, Shylo, Scott D, Weatherbee
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Expression of Oct4 Protein in Astrocytic Tumours-Histopathologic and Immunohistochemical Study [PDF]
Journal of Clinical and Diagnostic Research, 2018 Introduction: The majority of gliomas in adults are resistant to therapy. Therapy resistance has been attributed to the presence of cancer stem cells (CSCs).
Menar M Al-Sayed Ayoub +3 more
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