Results 21 to 30 of about 43,496 (227)
Oct4-Transfection한 중간엽줄기세포 유래 핵이식 배반포의 Oct4 발현 분포 및 세포 자멸사의 변화에 관한 연구
Journal of Animal Reproduction and Biotechnology, 2016 There are various factors i.e. donor cell type, culture system as well as technical procedures which influence the pre-implantation embryonic development; however, may attempts have been made and still it is under investigation to improve the cloning ...
Won-Jae Lee +3 more
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Radiology and Oncology, 2016 The data on expression and clinical impact of cancer stem cell markers SOX2, NANOG and OCT4 in lung cancer is still lacking. The aim of our study was to compare SOX2, NANOG and OCT4 mRNA expression levels in whole blood between advanced small-cell lung ...
Sodja Eva +5 more
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OCT4: A penetrant pluripotency inducer
Cell Regeneration, 2014 Native OCT4 protein has the intrinsic ability of crossing cellular membranes to enter cells. This finding could revive efforts to induce pluripotency with proteins replacing nucleic acid-based approaches, and raises the intriguing question as to whether OCT4 can act non-cell-autonomously.
Jauch, Ralf, Wang, Xuecong
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Transcriptional regulation of Oct4 by a long non-coding RNA antisense to Oct4-pseudogene 5 [PDF]
Transcription, 2010 Long non-coding RNAs (lncRNAs) have been shown to epigenetically regulate certain genes in human cells. Here we report evidence for the involvement of an antisense lncRNA in the transcriptional regulation of the pluripotency-associated factor Oct4. When an lncRNA antisense to Oct4-pseudogene 5 was suppressed, transcription of Oct4 and Oct4 pseudogenes ...
Peter G, Hawkins, Kevin V, Morris
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Effect of Intracytoplasmic Sperm Injection (ICSI) on Mouse Embryos Preimplantational Development
Scientific Papers Animal Science and Biotechnologies, 2023 It is known that the in vitro culture (IVC) of preimplantation embryos is associated with changes in gene expression. It is however, not known if the method of fertilization affects the global pattern of gene expression.
Claudia Cârste +5 more
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The roles of long noncoding RNAs in the regulation of OCT4 expression
Stem Cell Research & Therapy, 2022 OCT4 is a major transcription factor that maintains the pluripotency of stem cells, including embryonic stem cells, induced pluripotent stem cells and cancer stem cells. An increasing number of long noncoding RNAs have been reported to participate in the
Rui-Ting Zhou, Yi-Ran Ni, Fan-Jun Zeng
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Transcriptional Regulation of Nanog by OCT4 and SOX2 [PDF]
Journal of Biological Chemistry, 2005 Nanog, Sox2, and Oct4 are transcription factors all essential to maintaining the pluripotent embryonic stem cell phenotype. Through a cooperative interaction, Sox2 and Oct4 have previously been described to drive pluripotent-specific expression of a number of genes. We now extend the list of Sox2-Oct4 target genes to include Nanog.
Rodda, D.J. +6 more
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OCT4 interprets and enhances nucleosome flexibility
Nucleic Acids Research, 2022 Abstract Pioneer transcription factors are proteins that induce cellular identity transitions by binding to inaccessible regions of DNA in nuclear chromatin. They contribute to chromatin opening and recruit other factors to regulatory DNA elements.
MacCarthy, Caitlin M +10 more
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FUS-dependent loading of SUV39H1 to OCT4 pseudogene-lncRNA programs a silencing complex with OCT4 promoter specificity [PDF]
Communications Biology, 2020 AbstractThe resurrection of pseudogenes during evolution produced lncRNAs with new biological function. Here we show that pseudogene-evolution created an Oct4 pseudogene lncRNA that is able to direct epigenetic silencing of the parental Oct4 gene via a 2-step, lncRNA dependent mechanism.
Michele Scarola +6 more
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Targeting aggressive cancer stem cells in glioblastoma
Frontiers in Oncology, 2015 Glioblastoma (GBM) is the most common and fatal type of primary brain tumor. Gliosarcoma (GSM) is a rarer and more aggressive variant of GBM that has recently been considered a potentially different disease.
Tracy Christina Seymour +2 more
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