Results 41 to 50 of about 75,125 (295)

Transcriptional Regulation of Nanog by OCT4 and SOX2 [PDF]

Journal of Biological Chemistry, 2005
Nanog, Sox2, and Oct4 are transcription factors all essential to maintaining the pluripotent embryonic stem cell phenotype. Through a cooperative interaction, Sox2 and Oct4 have previously been described to drive pluripotent-specific expression of a number of genes. We now extend the list of Sox2-Oct4 target genes to include Nanog.
Rodda, D.J., Chew, J.-L., Lim, L.-H., Loh, Y.-H., Wang, B., Ng, H.-H., Robson, P.   +6 more
openaire   +2 more sources

OCT4 interprets and enhances nucleosome flexibility

Nucleic Acids Research, 2022
Abstract Pioneer transcription factors are proteins that induce cellular identity transitions by binding to inaccessible regions of DNA in nuclear chromatin. They contribute to chromatin opening and recruit other factors to regulatory DNA elements.
MacCarthy, Caitlin M, Huertas, Jan, Ortmeier, Claudia, Vom Bruch, Hermann, Tan, Daisylyn Senna, Reinke, Deike, Sander, Astrid, Bergbrede, Tim, Jauch, Ralf, Schöler, Hans R, Cojocaru, Vlad   +10 more
openaire   +2 more sources

NBMA Promotes Spermatogenesis by Mediating Oct4 Pathway [PDF]

ChemistryOpen, 2022
AbstractNon‐obstructive azoospermia is one of the most common causes of male infertility, but there is still no specific treatment drug. Given that the Oct4 (Octamer‐binding transcription factor 4) has an important regulatory effect on spermatogenesis, activating it can effectively promote spermatogenesis, so it is of great value to develop Oct4 ...
Jinfei Yang, Dengfeng Lin, Weiwei Yao, Damin Yun, Liwei Zhou, Sheng Gao, Fei Sun   +6 more
openaire   +3 more sources

First steps to define murine amniotic fluid stem cell microenvironment [PDF]

, 2016
Stem cell niche refers to the microenvironment where stem cells reside in living organisms. Several elements define the niche and regulate stem cell characteristics, such as stromal support cells, gap junctions, soluble factors, extracellular matrix ...
Bertin, Enrica, Bonaldo, Paolo, Braghetta, Paola, DE COPPI, Paolo, Dedja, Arben, Dona', Silvia, Franzin, Chiara, Piccoli, Martina, Pozzobon, Michela, Schiavi, Francesca, Spiro, Giovanna, Taschin, E.   +11 more
core   +3 more sources

FUS-dependent loading of SUV39H1 to OCT4 pseudogene-lncRNA programs a silencing complex with OCT4 promoter specificity [PDF]

Communications Biology, 2020
AbstractThe resurrection of pseudogenes during evolution produced lncRNAs with new biological function. Here we show that pseudogene-evolution created an Oct4 pseudogene lncRNA that is able to direct epigenetic silencing of the parental Oct4 gene via a 2-step, lncRNA dependent mechanism.
Michele Scarola, Elisa Comisso, Massimo Rosso, Giannino Del Sal, Claudio Schneider, Stefan Schoeftner, Roberta Benetti   +6 more
openaire   +4 more sources

Suv4-20h Histone Methyltransferases Promote Neuroectodermal Differentiation by Silencing the Pluripotency-Associated Oct-25 Gene [PDF]

, 2013
Post-translational modifications (PTMs) of histones exert fundamental roles in regulating gene expression. During development, groups of PTMs are constrained by unknown mechanisms into combinatorial patterns, which facilitate transitions from uncommitted
A Barski, A Magklara, AK Teo, Anne C. Ferguson-Smith, BM Lee, CD Rogers, CS Hinkley, Dario Nicetto, E Meshorer, E Meshorer, G Schotta, G Schotta, GM Morrison, Gunnar Schotta, H Niwa, I Munoz-Sanjuan, JH Lee, Julia Jung, K Takebayashi-Suzuki, L Yang, LA Banaszynski, LA Boyer, LA Boyer, M Hemberger, M Snir, M Tachibana, M Thomson, Matthias Hahn, N Singhal, NL Vastenhouw, NS Christophersen, P Kapoor-Vazirani, R Cao, R David, Ralph A. W. Rupp, RC Akkers, Robert David, S Dambacher, S Rea, SA Blythe, SC Dillon, SR Bhaumik, SV Saladi, T Hashimshony, T Hollemann, T Kwon, TD Schneider, Tobias D. Schneider, Tobias Straub, TS Mikkelsen, U Hellsten, VL Biron, WA Harris, Y Cao, Y Cao, Y Cao, Y Zhang, Z Li   +57 more
core   +3 more sources

Unveiling combinatorial regulation through the combination of ChIP information and in silico cis-regulatory module detection [PDF]

, 2012
Computationally retrieving biologically relevant cis-regulatory modules (CRMs) is not straightforward. Because of the large number of candidates and the imperfection of the screening methods, many spurious CRMs are detected that are as high scoring as ...
Fierro, Ana Carolina, Guns, Tias, Marchal, Kathleen, Nijssen, Siegfried, Sun, Hong, Thorrez, Lieven   +5 more
core   +2 more sources

Oct4 mediates tumor initiating properties in oral squamous cell carcinomas through the regulation of epithelial-mesenchymal transition. [PDF]

PLoS ONE, 2014
Overexpression of Oct4, an important transcription factor of embryonic stem cells (ESC), has been reported in several cancers. The aim of this study was to determine the emerging role of Oct4 in oral squamous cell carcinoma (OSCC) both in vitro and in ...
Lo-Lin Tsai, Fang-Wei Hu, Shiuan-Shinn Lee, Chuan-Hang Yu, Cheng-Chia Yu, Yu-Chao Chang   +5 more
doaj   +1 more source

Targeting aggressive cancer stem cells in glioblastoma

Frontiers in Oncology, 2015
Glioblastoma (GBM) is the most common and fatal type of primary brain tumor. Gliosarcoma (GSM) is a rarer and more aggressive variant of GBM that has recently been considered a potentially different disease.
Tracy Christina Seymour, Anna eNowak, Foteini eKakulas   +2 more
doaj   +1 more source

NonO Binds to the CpG Island of oct4 Promoter and Functions as a Transcriptional Activator of oct4 Gene Expression [PDF]

Molecules and Cells, 2013
We investigated the relationship between oct4 gene expression patterns and CpG sites methylation profiles during ES cell differentiation into neurons, and identified relevant binding factor. The oct4 gene expression level gradually declined as ES cell differentiation progressed, and the CpG sites in the oct4 proximal enhancer (PE) and promoter regions ...
Yoojin, Park, Ja-Myong, Lee, Min-Young, Hwang, Gi-hoon, Son, Dongho, Geum   +4 more
openaire   +2 more sources