Results 41 to 50 of about 54,485 (283)
Effect of Intracytoplasmic Sperm Injection (ICSI) on Mouse Embryos Preimplantational Development
Scientific Papers Animal Science and Biotechnologies, 2023 It is known that the in vitro culture (IVC) of preimplantation embryos is associated with changes in gene expression. It is however, not known if the method of fertilization affects the global pattern of gene expression.
Claudia Cârste +5 more
doaj
The roles of long noncoding RNAs in the regulation of OCT4 expression
Stem Cell Research & Therapy, 2022 OCT4 is a major transcription factor that maintains the pluripotency of stem cells, including embryonic stem cells, induced pluripotent stem cells and cancer stem cells. An increasing number of long noncoding RNAs have been reported to participate in the
Rui-Ting Zhou, Yi-Ran Ni, Fan-Jun Zeng
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Transcriptional Regulation of Nanog by OCT4 and SOX2 [PDF]
Journal of Biological Chemistry, 2005 Nanog, Sox2, and Oct4 are transcription factors all essential to maintaining the pluripotent embryonic stem cell phenotype. Through a cooperative interaction, Sox2 and Oct4 have previously been described to drive pluripotent-specific expression of a number of genes. We now extend the list of Sox2-Oct4 target genes to include Nanog.
Rodda, D.J. +6 more
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Targeting aggressive cancer stem cells in glioblastoma
Frontiers in Oncology, 2015 Glioblastoma (GBM) is the most common and fatal type of primary brain tumor. Gliosarcoma (GSM) is a rarer and more aggressive variant of GBM that has recently been considered a potentially different disease.
Tracy Christina Seymour +2 more
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NBMA Promotes Spermatogenesis by Mediating Oct4 Pathway [PDF]
ChemistryOpen, 2022 AbstractNon‐obstructive azoospermia is one of the most common causes of male infertility, but there is still no specific treatment drug. Given that the Oct4 (Octamer‐binding transcription factor 4) has an important regulatory effect on spermatogenesis, activating it can effectively promote spermatogenesis, so it is of great value to develop Oct4 ...
Jinfei Yang +6 more
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OCT4: A penetrant pluripotency inducer
Cell Regeneration, 2014 Native OCT4 protein has the intrinsic ability of crossing cellular membranes to enter cells. This finding could revive efforts to induce pluripotency with proteins replacing nucleic acid-based approaches, and raises the intriguing question as to whether OCT4 can act non-cell-autonomously.
Jauch, Ralf, Wang, Xuecong
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FUS-dependent loading of SUV39H1 to OCT4 pseudogene-lncRNA programs a silencing complex with OCT4 promoter specificity [PDF]
Communications Biology, 2020 AbstractThe resurrection of pseudogenes during evolution produced lncRNAs with new biological function. Here we show that pseudogene-evolution created an Oct4 pseudogene lncRNA that is able to direct epigenetic silencing of the parental Oct4 gene via a 2-step, lncRNA dependent mechanism.
Michele Scarola +6 more
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Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the role of High-mobility group box-1 (HMGB1) protein in regulating the expression of cancer stem cell markers Nanog, OCT4 and Sox2.
WANG Hua +4 more
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Higher LSD1 in Non-Seminomatous Germ Cell Tumors and LSD1 Inhibition by NCL1 Suppresses Embryonal Carcinoma Growth. [PDF]
Cancer SciLSD1 expression was higher in non‐seminomatous than in seminomatous testicular germ cell tumor components. In embryonal carcinoma models, selective LSD1 inhibition by NCL1 induced epigenetic and apoptotic responses, reduced viability including in cisplatin‐adapted cells, and suppressed early xenograft outgrowth, supporting LSD1 as a potential ...
Shimizu N +16 more
europepmc +2 more sources