Results 41 to 50 of about 43,496 (227)

The diagnostic value of cytoplasmic expression of the transcription factor Oct4 in neuroendocrine tumors

Alʹmanah Kliničeskoj Mediciny
Background: The transcription factor Oct4 plays an important role in tumor progression; however, it has not been adequately studied in neuroendocrine neoplasms. Its impact on the differentiation, functional activity of neuroendocrine cells and mechanisms
Larisa E. Gurevich, Irena A. Ilovayskaya, Anna Y. Lugovskaya, Ekaterina V. Markarova, Lali M. Kogoniya, Galiya R. Setdikova, Vlada M. Tyurina, Irina P. Yakovenko   +7 more
doaj   +1 more source

Connecting Oct4 to chromatin [PDF]

Nature Reports Stem Cells, 2009
An RNAi screen finds a protein complex that keeps pluripotency genes open for ...
openaire   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy

Advanced Science, EarlyView.
Tumor metabolism and epigenetic regulation are intrinsically linked. This review highlights lactylation as a pivotal bridge connecting these processes, acting as an active epigenetic effector in cancer stemness. We delineate how lactylation orchestrates the cancer stem cell landscape and evaluate its regulatory networks.
Ting Li, Hongyu Gu, Chang Liu, Yuesheng Lv, Feifei Li, Liang Liang, Jia Yi, Xuanyi Wang, Yi Zhun Zhu, Chuan Xu   +9 more
wiley   +1 more source

Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4 Protein Stability in Mouse Embryonic Stem Cells

Stem Cell Reports, 2017
Summary: The POU transcription factor OCT4 is critical for maintaining the undifferentiated state of embryonic stem cells (ESCs) and generating induced pluripotent stem cells (iPSCs), but its precise mechanisms of action remain poorly understood.
Ki Beom Bae, Dong Hoon Yu, Kun Yeong Lee, Ke Yao, Joohyun Ryu, Do Young Lim, Tatyana A. Zykova, Myoung Ok Kim, Ann M. Bode, Zigang Dong   +9 more
doaj   +1 more source

The Pro-Survival Oct4/Stat1/Mcl-1 Axis Is Associated with Poor Prognosis in Lung Adenocarcinoma Patients

Cells, 2021
The embryonic stem cell marker Oct4 is expressed in several human cancers and is positively correlated with a poor outcome in cancer patients. However, its physiological role in cancer progression remains poorly understood. Tumor cells block apoptosis to
Yu-Chu Su, Yi-Cheng Chen, Yau-Lin Tseng, Gia-Shing Shieh, Pensee Wu, Ai-Li Shiau, Chao-Liang Wu   +6 more
doaj   +1 more source

Bidirectional talk between AhR and Oct4

Oncotarget, 2015
The aryl hydrocarbon receptor (AhR) is a member of the family of basic helix-loop-helix transcription factors that is widely expressed in most differentiated mammalian cells and implicated in a variety of cellular processes, such as cell cycle progression, cell migration, carcinogenesis and immune functions. Upon the binding of its synthetic or natural
Bo, Kang, Ying-Jie, Wang
openaire   +2 more sources

Developmentally Inspired Bioprinting of Nascent Multicellular Human Heart Tissue Through in Situ Differentiation and Morphogenesis of iPSCs

Advanced Science, EarlyView.
A developmentally inspired bioprinting approach enables the fabrication of pluripotent tissues that undergo shape‐morphing and in situ cardiac lineage specification. This method employs embedded bioprinting to deposit iPSCs within soft granular hydrogels to create pluripotent tissue constructs that undergo cell‐mediated shape morphogenesis.
Ankita Pramanick, Juhi Chakraborty, Orlaith Kennedy, Hey Wei Wong, Sogol Kianersi, Daniel Kelly, Vasileios Sergis, Abhay Pandit, Andrew C. Daly   +8 more
wiley   +1 more source

The regulation of Oct4 in human gingival fibroblasts stimulated by cyclosporine A: Preliminary observations

Journal of Dental Sciences, 2020
Background/purpose: Oct4, a key transcription factor, could reprogram human somatic fibroblasts into embryonic stem cell-like pluripotent cells. The exact mechanism of cyclosporine A (CsA)-induced gingival overgrowth is still unclear.
Cheng-Chia Yu, Chia-Ming Liu, Tai-Chen Lin, Ni-Yu Su, Li-Chiu Yang, Yu-Chao Chang   +5 more
doaj   +1 more source

Involvement of crosstalk between Oct4 and Meis1a in neural cell fate decision. [PDF]

PLoS ONE, 2013
Oct4 plays a critical role both in maintaining pluripotency and the cell fate decision of embryonic stem (ES) cells. Nonetheless, in the determination of the neuroectoderm (NE) from ES cells, the detailed regulation mechanism of the Oct4 gene expression ...
Takeyuki Yamada, Yumiko Urano-Tashiro, Saori Tanaka, Hirotada Akiyama, Fumio Tashiro   +4 more
doaj   +1 more source