Results 51 to 60 of about 54,485 (283)

Human PPIN topological properties of 1TF (OCT4 or SOX2 or NANOG), 2TF (OCT4-SOX2 or OCT4-NANOG or SOX2-NANOG) and 3TF (OCT4-SOX2-NANOG) targets.

, 2014
Human PPIN topological properties of 1TF (OCT4 or SOX2 or NANOG), 2TF (OCT4-SOX2 or OCT4-NANOG or SOX2-NANOG) and 3TF (OCT4-SOX2-NANOG) targets.
Liangcai Zhang (156659), Jinlian Hua (182220), Shihua Zhang (21549), Guiyou Liu (224712), Lei Yang (102719), Yongshuai Jiang (194259), Rennan Feng (186785), Mingzhi Liao (473967), Leijie Li (623371)   +8 more
core   +1 more source

NonO Binds to the CpG Island of oct4 Promoter and Functions as a Transcriptional Activator of oct4 Gene Expression [PDF]

Molecules and Cells, 2013
We investigated the relationship between oct4 gene expression patterns and CpG sites methylation profiles during ES cell differentiation into neurons, and identified relevant binding factor. The oct4 gene expression level gradually declined as ES cell differentiation progressed, and the CpG sites in the oct4 proximal enhancer (PE) and promoter regions ...
Yoojin, Park, Ja-Myong, Lee, Min-Young, Hwang, Gi-hoon, Son, Dongho, Geum   +4 more
openaire   +2 more sources

Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2 [PDF]

, 2019
Oct4, along with Sox2 and Klf4 (SK), can induce pluripotency but structurally similar factors like Oct6 cannot. To decode why Oct4 has this unique ability, we compare Oct4-binding, accessibility patterns and transcriptional waves with Oct6 and an Oct4 ...
Holzner, M., Zimmer, D, Hutchins, AP, Zimmer, D., Veerapandian, V., Jauch, R, Weng, M, Schöler, HR, Glaser, L., Wang, H., Malik, V., Velychko, S., Weng, M., Chen, Y, Scholer, H., Holzner, M, Wang, H, Glaser, LV, Chen, J, Pott, S, Pott, S., Meijsing, SH, Arend, M., Hutchins, A., Esteban, M., Jauch, R., Chen, Y., Arend, M, Velychko, S, Shah, Z, Malik, V, Chen, J., Srivastava, Y, Srivastava, Y., Shah, Z., Veerapandian, V, Meijsing, S., Esteban, MA   +37 more
core   +1 more source

Oct4 mediates tumor initiating properties in oral squamous cell carcinomas through the regulation of epithelial-mesenchymal transition. [PDF]

PLoS ONE, 2014
Overexpression of Oct4, an important transcription factor of embryonic stem cells (ESC), has been reported in several cancers. The aim of this study was to determine the emerging role of Oct4 in oral squamous cell carcinoma (OSCC) both in vitro and in ...
Lo-Lin Tsai, Fang-Wei Hu, Shiuan-Shinn Lee, Chuan-Hang Yu, Cheng-Chia Yu, Yu-Chao Chang   +5 more
doaj   +1 more source

Meis1a suppresses Oct4 expression.

, 2013
(A) Reduction of Oct4 by ectopic expression of Meis1a RNA. P19 cells were transfected with the vacant vector or pcDNA3-EF1-α-Oct4 and after 24 h, these aggregated cells were treated with RA for 0 and 6 h.
Yumiko Urano-Tashiro (381737), Fumio Tashiro (381738), Saori Tanaka (370508), Hirotada Akiyama (230768), Takeyuki Yamada (381736)   +4 more
core   +1 more source

Connecting Oct4 to chromatin [PDF]

Nature Reports Stem Cells, 2009
An RNAi screen finds a protein complex that keeps pluripotency genes open for ...
openaire   +1 more source

Nucleosome binding by the pioneer transcription factor OCT4 [PDF]

Scientific Reports, 2020
AbstractTranscription factor binding to genomic DNA is generally prevented by nucleosome formation, in which the DNA is tightly wrapped around the histone octamer. In contrast, pioneer transcription factors efficiently bind their target DNA sequences within the nucleosome.
Echigoya, Kenta, Koyama, Masako, Negishi, Lumi, Takizawa, Yoshimasa, Mizukami, Yuka, Shimabayashi, Hideki, Kuroda, Akari, Kurumizaka, Hitoshi   +7 more
openaire   +2 more sources

OCT4 induces EMT and promotes ovarian cancer progression by regulating the PI3K/AKT/mTOR pathway

Frontiers in Oncology, 2022
BackgroundOctamer-binding transcription factor 4 (OCT4) is a key stem cell transcription factor involved in the development of various cancers. The role of OCT4 in ovarian cancer (OC) progression and its molecular mechanism are not fully understood ...
Weiwei Xie, Jun Yu, Yujia Yin, Xiaoqian Zhang, Xiaocui Zheng, Xipeng Wang   +5 more
doaj   +1 more source

OCT4 is post-translationally modified.

, 2014
A. HEK293T cells transfected with a His6-OCT4 expression plasmid for 48 h were treated with vehicle, MG132 or CoCl2 for 3 h. Equal amounts of cell lysates were incubated with Ni-NTA resin.
Tao Cheng (131540), Yupo Ma (236944), Yixin Yao (353108), Wei Dai (95957), Wen-Chi Chen (286343), Yongping Jiang (296449), Lou Lu (518137), Yinghua Lu (518136)   +7 more
core   +1 more source

Microgels Enable iPSCs to Assemble, Expand, and Differentiate Into Organoids—From Sizable to High‐Throughput

Advanced Materials, EarlyView.
A chemically defined PEG‐based microgel platform enables scalable, reproducible production of three‐dimensional microgel‐iPSC constructs in multiple sizes. The system is compatible with high‐throughput automation and supports human iPSC expansion and differentiation within a single construct, including directed differentiation into cardiac organoids ...
Laura Klasen, Matthias Mork, Ramin Nasehi, Vasudha Turuvekere Krishnamurthy, Kira Zeevaert, Aaron Babendreyer, Jacopo Di Russo, Wolfgang Wagner, Laura De Laporte   +8 more
wiley   +1 more source