Results 61 to 70 of about 54,485 (283)

Impacts of Haematococcus pluvialis extract on the expression of the SOX2 and OCT4 genes in the prostate cancer cell line, PC3 [PDF]

Caspian Journal of Environmental Sciences
There is a small population of cells with stem cell properties in cancer tissues that are responsible for the initiation of tumour formation and have the ability to resist apoptosis inducing agents and chemotherapy. SOX2 is a transcription factor in stem
Mahsa Khatami, Fatemeh Moradi, Mahmoudreza Aghamaali, Seyedeh Fatemeh Fallah   +3 more
doaj   +1 more source

Ubiquitous depletion of Oct4 ∼E7.5 results in the Oct4^{COND MUT} phenotype ∼E9.5.

, 2013
A–C E9.5 Oct4f/f embryo with no phenotype and Oct4COND MUT (Oct4f/f;CreERT2+/−) littermates. Tamoxifen was administered ∼E7.0 and ∼E7.5 and embryos dissected ∼E9.5 (Table S1D). Scale bars in ‘A–C’ are 200 µm. A Sagittal view. Arrows indicate somites that
Andras Nagy (58911), Paria Mohseni (484734), Alexey Tomilin (197899), Larysa Pevny (484737), Charles Yoon (484735), Anthony Lin (484736), Irina Brokhman (484733), Peter W. Zandstra (79978), Kento Onishi (261459), Brian DeVeale (174713), Tomas Babak (6744), Derek van der Kooy (7574)   +11 more
core   +1 more source

Evidence that transcription factor AP-2γ is not required for Oct4 repression in mouse blastocysts.

PLoS ONE, 2013
In mouse blastocysts segregation of the inner cell mass (ICM) and the trophectoderm (TE) is regulated by the mutually antagonistic effects of the transcription factors Oct4 and Cdx2 expressed in the ICM and TE, respectively. In contrast, in other species
Inchul Choi, Timothy S Carey, Catherine A Wilson, Jason G Knott   +3 more
doaj   +1 more source

Oct4 activates Meis1a expression.

, 2013
Monolayer-cultured P19 cells were transfected with the pcDNA3-EF1-α-Oct4 expression vector and after 24 h Meis1a and Oct4 mRNAs and proteins were analyzed by RT-PCR (A) and WB (B), respectively.
Yumiko Urano-Tashiro (381737), Fumio Tashiro (381738), Saori Tanaka (370508), Hirotada Akiyama (230768), Takeyuki Yamada (381736)   +4 more
core   +1 more source

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source

The diagnostic value of cytoplasmic expression of the transcription factor Oct4 in neuroendocrine tumors

Alʹmanah Kliničeskoj Mediciny
Background: The transcription factor Oct4 plays an important role in tumor progression; however, it has not been adequately studied in neuroendocrine neoplasms. Its impact on the differentiation, functional activity of neuroendocrine cells and mechanisms
Larisa E. Gurevich, Irena A. Ilovayskaya, Anna Y. Lugovskaya, Ekaterina V. Markarova, Lali M. Kogoniya, Galiya R. Setdikova, Vlada M. Tyurina, Irina P. Yakovenko   +7 more
doaj   +1 more source

Oct4-GFP expression characteristics.

, 2014
A) Immunofluorescence of Oct4-GFP transgenic iPSC line LV1-7b cultured in non-differentiating conditions. Depicted are the Oct4-GFP marker, staining for OCT4 protein, a DAPI counterstain and phase contrast images.
Sebastian Knöbel (599152), Eva Warlich (599148), Axel Schambach (214256), Silke Glage (108551), Dirk Wedekind (295505), Dominik Lock (599149), Andreas Bosio (599151), Dominik Eckardt (599150)   +7 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Involvement of crosstalk between Oct4 and Meis1a in neural cell fate decision. [PDF]

PLoS ONE, 2013
Oct4 plays a critical role both in maintaining pluripotency and the cell fate decision of embryonic stem (ES) cells. Nonetheless, in the determination of the neuroectoderm (NE) from ES cells, the detailed regulation mechanism of the Oct4 gene expression ...
Takeyuki Yamada, Yumiko Urano-Tashiro, Saori Tanaka, Hirotada Akiyama, Fumio Tashiro   +4 more
doaj   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source