Results 61 to 70 of about 75,125 (295)

The diagnostic value of cytoplasmic expression of the transcription factor Oct4 in neuroendocrine tumors

Alʹmanah Kliničeskoj Mediciny
Background: The transcription factor Oct4 plays an important role in tumor progression; however, it has not been adequately studied in neuroendocrine neoplasms. Its impact on the differentiation, functional activity of neuroendocrine cells and mechanisms
Larisa E. Gurevich, Irena A. Ilovayskaya, Anna Y. Lugovskaya, Ekaterina V. Markarova, Lali M. Kogoniya, Galiya R. Setdikova, Vlada M. Tyurina, Irina P. Yakovenko   +7 more
doaj   +1 more source

Systematic optimization of human pluripotent stem cells media using Design of Experiments. [PDF]

, 2015
Human pluripotent stem cells (hPSC) are used to study the early stages of human development in vitro and, increasingly due to somatic cell reprogramming, cellular and molecular mechanisms of disease.
Chailangkarn, Thanathom, Marinho, Paulo A, Muotri, Alysson R   +2 more
core   +1 more source

Connecting Oct4 to chromatin [PDF]

Nature Reports Stem Cells, 2009
An RNAi screen finds a protein complex that keeps pluripotency genes open for ...
openaire   +1 more source

Polymer Matrix‐Based 3D Culture Significantly Enhances the Differentiation and Immunomodulatory Functions of Human Adipose‐Derived Stem Cells

Advanced Science, EarlyView.
The 3D culture of human adipose‐derived stem cells (hADSCs) on a crosslinked cyclosiloxane‐based poly‐Z matrix platform enables the formation of spheroid structures enriched with extracellular matrix (ECM). These ECM‐enriched hADSC spheroids cultured on poly‐Z exhibit enhanced differentiation potential, immunomodulatory capacity, and in vivo ...
Changjin Seo, Dohyeon Kim, Junhyuk Song, Sun‐Young Kim, Youngju Son, Afia Tasnim Rahman, Sangyong Jon   +6 more
wiley   +1 more source

The Pro-Survival Oct4/Stat1/Mcl-1 Axis Is Associated with Poor Prognosis in Lung Adenocarcinoma Patients

Cells, 2021
The embryonic stem cell marker Oct4 is expressed in several human cancers and is positively correlated with a poor outcome in cancer patients. However, its physiological role in cancer progression remains poorly understood. Tumor cells block apoptosis to
Yu-Chu Su, Yi-Cheng Chen, Yau-Lin Tseng, Gia-Shing Shieh, Pensee Wu, Ai-Li Shiau, Chao-Liang Wu   +6 more
doaj   +1 more source

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

Advanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang, Haowei Fang, Lili Qi, Song Myoungseop, Aawrish Khan, Lunli Gong, Guangdong Zhou, Kunxi Zhang, Haiyan Cui   +8 more
wiley   +1 more source

Oct4 transcriptionally regulates the expression of long non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression

Molecular Cancer, 2017
Background Oct4, a key stemness transcription factor, is overexpressed in lung cancer. Here, we reveal a novel transcription regulation of long non-coding RNAs (lncRNAs) by Oct4. LncRNAs have emerged as important players in cancer progression.
Jayu Jen, Yen-An Tang, Ying-Hung Lu, Che-Chung Lin, Wu-Wei Lai, Yi-Ching Wang   +5 more
doaj   +1 more source

The regulation of Oct4 in human gingival fibroblasts stimulated by cyclosporine A: Preliminary observations

Journal of Dental Sciences, 2020
Background/purpose: Oct4, a key transcription factor, could reprogram human somatic fibroblasts into embryonic stem cell-like pluripotent cells. The exact mechanism of cyclosporine A (CsA)-induced gingival overgrowth is still unclear.
Cheng-Chia Yu, Chia-Ming Liu, Tai-Chen Lin, Ni-Yu Su, Li-Chiu Yang, Yu-Chao Chang   +5 more
doaj   +1 more source

Developmentally Inspired Bioprinting of Nascent Multicellular Human Heart Tissue Through in Situ Differentiation and Morphogenesis of iPSCs

Advanced Science, EarlyView.
A developmentally inspired bioprinting approach enables the fabrication of pluripotent tissues that undergo shape‐morphing and in situ cardiac lineage specification. This method employs embedded bioprinting to deposit iPSCs within soft granular hydrogels to create pluripotent tissue constructs that undergo cell‐mediated shape morphogenesis.
Ankita Pramanick, Juhi Chakraborty, Orlaith Kennedy, Hey Wei Wong, Sogol Kianersi, Daniel Kelly, Vasileios Sergis, Abhay Pandit, Andrew C. Daly   +8 more
wiley   +1 more source

Enhanced human somatic cell reprogramming efficiency by fusion of the MYC transactivation domain and OCT4

Stem Cell Research, 2017
The development of human induced pluripotent stem cells (iPSCs) holds great promise for regenerative medicine. However the iPSC induction efficiency is still very low and with lengthy reprogramming process.
Ling Wang, Delun Huang, Chang Huang, Yexuan Yin, Kaneha Vali, Ming Zhang, Young Tang   +6 more
doaj   +1 more source