Results 81 to 90 of about 54,485 (283)

Akt phosphorylates Oct4 and accelerates its degradation.

, 2013
(A) Oct4 phosphorylation by Akt is ATP-dependent. (B) Akt phosphorylates GST-Oct4, but not GST, GST-Oct4T228A, GST-Oct4T228D or GST-Oct4T228E. Under the same reaction condition, mutation of serine 229 to alanine or aspartic acid significantly reduced the
Zheng Xue (266750), Bingyang Shi (419014), Guanghui Yang (191351), Xue Wang (102830), Bo Chen (32294), Yue Huang (285485), Ben Yang (419015), Yuemin Yan (419016), Wenji Dong (419017), Daishu Han (346593)   +9 more
core   +1 more source

Human papillomavirus E7 binds Oct4 and regulates its activity in HPV-associated cervical cancers.

PLoS Pathogens, 2020
Octamer binding transcription factor-4 (Oct4), is highly expressed in stem cells and has indispensable roles in pluripotency and cellular reprogramming. In contrast to other factors used for cellular reprogramming, a role for Oct4 outside embryonic stem ...
Theofano Panayiotou, Stella Michael, Apostolos Zaravinos, Ece Demirag, Charis Achilleos, Katerina Strati   +5 more
doaj   +1 more source

The regulation of Oct4 in human gingival fibroblasts stimulated by cyclosporine A: Preliminary observations

Journal of Dental Sciences, 2020
Background/purpose: Oct4, a key transcription factor, could reprogram human somatic fibroblasts into embryonic stem cell-like pluripotent cells. The exact mechanism of cyclosporine A (CsA)-induced gingival overgrowth is still unclear.
Cheng-Chia Yu, Chia-Ming Liu, Tai-Chen Lin, Ni-Yu Su, Li-Chiu Yang, Yu-Chao Chang   +5 more
doaj   +1 more source

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

Inhibition of OCT4 binding at the MYCN locus induces neuroblastoma cell death accompanied by downregulation of transcripts with high-open reading frame dominance

Frontiers in Oncology
Amplification of MYCN is observed in high-risk neuroblastomas (NBs) and is associated with a poor prognosis. MYCN expression is directly regulated by multiple transcription factors, including OCT4, MYCN, CTCF, and p53 in NB.
Kazuma Nakatani, Kazuma Nakatani, Kazuma Nakatani, Kazuma Nakatani, Hiroyuki Kogashi, Hiroyuki Kogashi, Takanori Miyamoto, Taiki Setoguchi, Tetsushi Sakuma, Kazuto Kugou, Yoshinori Hasegawa, Takashi Yamamoto, Yoshitaka Hippo, Yoshitaka Hippo, Yoshitaka Hippo, Yusuke Suenaga   +15 more
doaj   +1 more source

SUMOylation impairs the protein-protein interaction between Oct4 and Sox2.

, 2012
NIH3T3 cells were cotransfected with various combinations of Oct4/Oct4 K118R, Sox2/Sox2 K247R, HA-Sumo1 and HA-Ubc9 expression plasmids as indicated.
Lixia Yang (156282), Wenzhong Li (156311), Bo Tang (23472), Yong Zhang (5893), Zekun Guo (156269), Haibo Wu (156272), Juan Du (118107), Xiaohai Wang (156274), Liping Yang (156318), Yongyan Wu (156264), Xiaoyan Shi (156294)   +10 more
core   +1 more source

OCT4 positively regulates Survivin expression to promote cancer cell proliferation and leads to poor prognosis in esophageal squamous cell carcinoma. [PDF]

PLoS ONE, 2012
BACKGROUND: OCT4 and Survivin are important factors for cancer cell proliferation, renewal and dedifferentiation, and correlate with resistance to radiotherapy and chemotherapy in most human cancers, but their regulatory mechanisms are not well known ...
Chunguang Li, Yan Yan, Weidan Ji, Longlong Bao, Haihua Qian, Lei Chen, Mengchao Wu, Hezhong Chen, Zhigang Li, Changqing Su   +9 more
doaj   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source

Biology of regeneration in earthworms: mechanisms, factors and molecular insights. A review

Romanian Journal of Ecology & Environmental Chemistry
Earthworms are ecosystem engineers that play a vital role in soil structure, nutrient cycling, and ecological balance. Beyond their ecological importance, they exhibit remarkable regenerative potential, making them valuable models for studying cellular ...
AMAR KUMAR, ANIRUDDHA MAHATO, SALMAN HAIDER, DAMODAR HEMBRAM, LAXMI SOREN, CHHOTAN MANDAL, ANIT KUMAR HANSDAH, SHALU PRIYA   +7 more
doaj   +1 more source

oct4

oct4 cut&tag in wt vs ...
Xiaomei Zhang (17756439)
core   +1 more source