Results 91 to 100 of about 75,125 (295)

Oct4 is required ~E7.5 for proliferation in the primitive streak. [PDF]

PLoS Genetics, 2013
Oct4 is a widely recognized pluripotency factor as it maintains Embryonic Stem (ES) cells in a pluripotent state, and, in vivo, prevents the inner cell mass (ICM) in murine embryos from differentiating into trophectoderm. However, its function in somatic
Brian DeVeale, Irina Brokhman, Paria Mohseni, Tomas Babak, Charles Yoon, Anthony Lin, Kento Onishi, Alexey Tomilin, Larysa Pevny, Peter W Zandstra, Andras Nagy, Derek van der Kooy   +11 more
doaj   +1 more source

Pluripotency factors functionally premark cell-type-restricted enhancers in ES cells. [PDF]

, 2018
Enhancers for embryonic stem (ES) cell-expressed genes and lineage-determining factors are characterized by conventional marks of enhancer activation in ES cells1-3, but it remains unclear whether enhancers destined to regulate cell-type-restricted ...
Destici, Eugin, Friedman, Meyer, Kim, Hong Sook, Ma, Qi, Ma, Wubin, Merkurjev, Daria, Ohgi, Kenneth, Rosenfeld, Michael G, Skowronska-Krawczyk, Dorota, Suter, Tom, Tan, Yuliang   +10 more
core   +2 more sources

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Inhibition of OCT4 binding at the MYCN locus induces neuroblastoma cell death accompanied by downregulation of transcripts with high-open reading frame dominance

Frontiers in Oncology
Amplification of MYCN is observed in high-risk neuroblastomas (NBs) and is associated with a poor prognosis. MYCN expression is directly regulated by multiple transcription factors, including OCT4, MYCN, CTCF, and p53 in NB.
Kazuma Nakatani, Kazuma Nakatani, Kazuma Nakatani, Kazuma Nakatani, Hiroyuki Kogashi, Hiroyuki Kogashi, Takanori Miyamoto, Taiki Setoguchi, Tetsushi Sakuma, Kazuto Kugou, Yoshinori Hasegawa, Takashi Yamamoto, Yoshitaka Hippo, Yoshitaka Hippo, Yoshitaka Hippo, Yusuke Suenaga   +15 more
doaj   +1 more source

Hierarchical Oct4 Binding in Concert with Primed Epigenetic Rearrangements during Somatic Cell Reprogramming

Cell Reports, 2016
The core pluripotency factor Oct4 plays key roles in somatic cell reprogramming through transcriptional control. Here, we profile Oct4 occupancy, epigenetic changes, and gene expression in reprogramming.
Jun Chen, Xiaolong Chen, Min Li, Xiaoyu Liu, Yawei Gao, Xiaochen Kou, Yanhong Zhao, Weisheng Zheng, Xiaobai Zhang, Yi Huo, Chuan Chen, You Wu, Hong Wang, Cizhong Jiang, Shaorong Gao   +14 more
doaj   +1 more source

Gene Expression Profile Changes After Short-activating RNA-mediated Induction of Endogenous Pluripotency Factors in Human Mesenchymal Stem Cells [PDF]

, 2012
It is now recognized that small noncoding RNA sequences have the ability to mediate transcriptional activation of specific target genes in human cells.
Alluin, J, Habib, N, Kasahara, N, Mintz, P, Rossi, J, Sun, G, Sætrom, P, Voutila, J   +7 more
core   +4 more sources

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Oct4 Gene Expression in Primary Colorectal Cancer Promotes Liver Metastasis

Stem Cells International, 2019
Purpose. The Oct4 gene plays an important role in undifferentiated embryonic stem cells and regulates stem cell pluripotency. The aim of this study was to examine the relationship between Oct4 expression and liver metastasis of colorectal cancer (CRC) in
Shiki Fujino, Norikatsu Miyoshi
doaj   +1 more source

Simulated microgravity promotes the formation of tridimensional cultures and stimulates pluripotency and a glycolytic metabolism in human hepatic and biliary tree stem/progenitor cells [PDF]

, 2019
Many pivotal biological cell processes are affected by gravity. The aim of our study was to evaluate biological and functional effects, differentiation potential and exo-metabolome profile of simulated microgravity (SMG) on human hepatic cell line (HepG2)
Alvaro, Domenico, Berloco, Pasquale Bartolomeo, Bizzarri, Mariano, Cardinale, Vincenzo, Carpino, Guido, Casadei, Luca, Costantini, Daniele, Di Matteo, Sabina, Gaudio, Eugenio, Manetti, Cesare, Melandro, Fabio, Nevi, Lorenzo, Overi, Diletta, Safarikia, Samira, Valerio, Mariacristina   +14 more
core   +2 more sources