Results 1 to 10 of about 70,327 (209)

FGF2 supports NANOG expression via pyruvate dehydrogenase–dependent histone acetylation under low oxygen conditions [PDF]

Frontiers in Cell and Developmental Biology
IntroductionThe safe and effective application of human pluripotent stem cells (hPSCs) in research and regenerative medicine requires precise control over pluripotency and cell fate.
Petr Fojtík, Petr Fojtík, Petr Fojtík, Martin Senfluk, Katerina Holomkova, Anton Salykin, Jana Gregorova, Pavel Smak, Ondrej Pes, Jan Raska, Jan Raska, Deborah Beckerova, Deborah Beckerova, Monika Stetkova, Petr Skladal, Miroslava Sedlackova, Ales Hampl, Ales Hampl, Dasa Bohaciakova, Dasa Bohaciakova, Stjepan Uldrijan, Stjepan Uldrijan, Vladimir Rotrekl, Vladimir Rotrekl   +23 more
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Comparative characteristic of lung cancer stem-like cells generated in vitro under different culture conditions [PDF]

The Ukrainian Biochemical Journal, 2021
Cancer stem cells (CSCs) play an important role in resistance to cancer treatment and recurrence developing. The aim of this study was to obtain cell culture of MOR line non-small cell lung cancer cells enriched in CSCs and to investigate its functional ...
O. V. Skachkova, O. I. Gorbach , M. V. Inomistova, L. V. Garmanchuk, N. M. Khranovska   +4 more
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NANOG expression in parthenogenetic porcine blastocysts is required for intact lineage specification and pluripotency [PDF]

Animal Bioscience, 2023
Objective Nanog homeobox (NANOG) is a core transcription factor that contributes to pluripotency along with octamer binding transcription factor-4 (OCT4) and sex determining region-Y box-2 (SOX2).
Mingyun Lee, Jong-Nam Oh, Gyung Cheol Choe, Kwang-Hwan Choi, Dong-Kyung Lee, Seung-Hun Kim, Jinsol Jeong, Yelim Ahn, Chang-Kyu Lee   +8 more
doaj   +1 more source

Loss of Pten causes tumor initiation following differentiation of murine pluripotent stem cells due to failed repression of Nanog. [PDF]

, 2011
Pluripotent stem cells (PSCs) hold significant promise in regenerative medicine due to their unlimited capacity for self-renewal and potential to differentiate into every cell type in the body. One major barrier to the use of PSCs is their potential risk
Banerjee, Utpal, Clark, Amander T, Jiao, Jing, Li, Xinmin, Lindgren, Anne G, Natsuhara, Kyle, Tian, E, Vincent, John J, Wu, Hong   +8 more
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Combination of Doxorubicin and Berberine Generated Synergistic Anticancer Effect on Breast Cancer Cells Through Down-regulation of Nanog and miRNA-21 Gene Expression

Middle East Journal of Cancer, 2020
Background: Our purpose was to investigate the effect of berberine (BER) and doxorubicin (DOX) on the expression of stem cell markers Nanog and microRNA- 21 in MCF-7 cells.
Samia A. Ebeid, Nadia A. Abd El Moneim, Hossam El-Din M. Ghoneim, Sanaa A. El-Benhawy, Samah E. Ismail   +4 more
doaj   +1 more source

A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in stemness and Notch signaling

Biology Open, 2021
The development of three-dimensional cell culture techniques has allowed cancer researchers to study the stemness properties of cancer cells in in vitro culture.
Katherine K. Slemmons, Michael D. Deel, Yi-Tzu Lin, Kristianne M. Oristian, Nina Kuprasertkul, Katia C. Genadry, Po-Han Chen, Jen-Tsan Ashley Chi, Corinne M. Linardic   +8 more
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Super-Enhancers and CTCF in Early Embryonic Cell Fate Decisions

Frontiers in Cell and Developmental Biology, 2021
Cell fate decisions are the backbone of many developmental and disease processes. In early mammalian development, precise gene expression changes underly the rapid division of a single cell that leads to the embryo and are critically dependent on ...
Puja Agrawal, Puja Agrawal, Sridhar Rao, Sridhar Rao, Sridhar Rao   +4 more
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Expression patterns and clinical significance of the potential cancer stem cell markers OCT4 and NANOG in colorectal cancer patients

Molecular & Cellular Oncology, 2020
Colorectal cancer (CRC) is one of the most important malignancies and causes of cancer-related deaths worldwide. Cancer stem cell markers identification could be helpful to acquire important prognostic information and develop new treatment regimens. This
Raheleh Roudi, Mahboubeh Barodabi, Zahra Madjd, Giandomenico Roviello, Silvia Paola Corona, Mahshid Panahi   +5 more
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NANOG/NANOGP8 Localizes at the Centrosome and is Spatiotemporally Associated with Centriole Maturation

Cells, 2020
NANOG is a transcription factor involved in the regulation of pluripotency and stemness. The functional paralog of NANOG, NANOGP8, differs from NANOG in only three amino acids and exhibits similar reprogramming activity.
Erika Mikulenkova, Jakub Neradil, Ondrej Vymazal, Jan Skoda, Renata Veselska   +4 more
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miR-150 suppresses the proliferation and tumorigenicity of leukemia stem cells by targeting the Nanog signaling pathway

Frontiers in Pharmacology, 2016
Proliferation, a key feature of cancer cells, accounts for the majority of cancer-related diseases resulting in mortality. MicroRNAs (miRNAs) plays important post-transcriptional modulation roles by acting on multiple signaling pathways, but the ...
Dan-dan Xu, Dan-dan Xu, Peng-jun Zhou, Peng-jun Zhou, Ying Wang, Ying Wang, Yi Zhang, Rong Zhang, Li Zhang, Su-hong Chen, Bi-bo Ruan, Hai-peng Xu, Wu-yu Fu, Chao-zhi Hu, Lu Tian, Jin-hong Qin, Sheng Wang, Xiao Wang, Qiu-ying Liu, Zhe Ren, Xue-qui Gu, Yao-he Li, Zhong Liu, Yi Fei Wang   +23 more
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