Results 1 to 10 of about 48,754 (252)
The roles of NANOG in tumorigenesis [PDF]
Molecular & Cellular Oncology, 2018 The pluripotency factor Nanog is highly expressed in pluripotent stem cells and certain adult stem cells, but is not expressed in normal adult cells. However, Nanog is frequently overexpressed in human cancers.
Jinchul Kim, Stefan Yu, Yang Xu
doaj +5 more sources
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on NANOG (Nanog homeobox), with data on DNA, on the protein encoded, and where the gene is implicated.
Schorle, H, Nettersheim, D
openaire +4 more sources
Role for Med12 in Regulation of Nanog and Nanog Target Genes [PDF]
Journal of Biological Chemistry, 2009 Nanog, Oct4, and Sox2 form the core of a transcription factor network that maintains embryonic stem cells in the pluripotent state in both humans and mice. These critical factors have been implicated as both positive and negative regulators of transcription, varying by promoter and differentiation state of the cell.
Antonin V, Tutter +6 more
openaire +4 more sources
Regulation of NANOG in cancer cells [PDF]
Molecular Carcinogenesis, 2015 As one of the key pluripotency transcription factors, NANOG plays a critical role in maintaining the self‐renewal and pluripotency in normal embryonic stem cells. Recent data indicate that NANOG is expressed in a variety of cancers and its expression correlates with poor survival in cancer patients. Of interest,
Tang Dg, Collene Jeter
exaly +3 more sources
Cross-regulation of the Nanog and Cdx2 promoters [PDF]
Cell Research, 2009 The first cell fate choice in the mammalian embryo, the segregation of the inner cell mass (ICM) and trophectoderm (TE), is regulated by the mutually antagonistic effects of the transcription factors, Oct4 and Cdx2, while the pluripotency factor, Nanog, is essential to specify the epiblast.
Konrad Hochedlinger +2 more
exaly +3 more sources
NANOG expression in human development and cancerogenesis
Experimental Biology and Medicine, 2020 NANOG is an important stem cell transcription factor involved in human development and cancerogenesis. Its expression is complex and regulated on different levels. Moreover, NANOG protein might regulate hundreds of target genes at the same time. NANOG is crucial for preimplantation development phase and progressively decreases during embryonic stem ...
Gasper Grubelnik +2 more
exaly +4 more sources
Comparative characteristic of lung cancer stem-like cells generated in vitro under different culture conditions [PDF]
The Ukrainian Biochemical Journal, 2021 Cancer stem cells (CSCs) play an important role in resistance to cancer treatment and recurrence developing. The aim of this study was to obtain cell culture of MOR line non-small cell lung cancer cells enriched in CSCs and to investigate its functional ...
O. V. Skachkova +4 more
doaj +1 more source
NANOG expression in parthenogenetic porcine blastocysts is required for intact lineage specification and pluripotency [PDF]
Animal Bioscience, 2023 Objective Nanog homeobox (NANOG) is a core transcription factor that contributes to pluripotency along with octamer binding transcription factor-4 (OCT4) and sex determining region-Y box-2 (SOX2).
Mingyun Lee +8 more
doaj +1 more source
Middle East Journal of Cancer, 2020 Background: Our purpose was to investigate the effect of berberine (BER) and doxorubicin (DOX) on the expression of stem cell markers Nanog and microRNA- 21 in MCF-7 cells.
Samia A. Ebeid +4 more
doaj +1 more source
A NANOG‐pERK reciprocal regulatory circuit regulates Nanog autoregulation and ERK signaling dynamics [PDF]
The EMBO Reports, 2021 Abstract The self‐renewal and differentiation potential of embryonic stem cells (ESCs) is maintained by the regulated expression of core pluripotency factors. Expression levels of the core pluripotency factor Nanog are tightly regulated by a negative feedback autorepression ...
Hanuman T Kale +7 more
openaire +2 more sources