Results 11 to 20 of about 48,754 (252)
Eleven daughters of NANOG☆ [PDF]
Genomics, 2004 Nanog is a recently discovered ANTP class homeobox gene. Mouse Nanog is expressed in the inner cell mass and in embryonic stem cells and has roles in self-renewal and maintenance of pluripotency. Here we describe the location, genomic organization, and relative ages of all human NANOG pseudogenes, comprising ten processed pseudogenes and one tandem ...
Booth, H, Holland, P
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Esrrb Is a Direct Nanog Target Gene that Can Substitute for Nanog Function in Pluripotent Cells [PDF]
Cell Stem Cell, 2012 Embryonic stem cell (ESC) self-renewal efficiency is determined by the level of Nanog expression. However, the mechanisms by which Nanog functions remain unclear, and in particular, direct Nanog target genes are uncharacterized. Here we investigate ESCs expressing different Nanog levels and Nanog(-/-) cells with distinct functionally inducible Nanog ...
Festuccia, Nicola +9 more
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Hypoblast Formation in Bovine Embryos Does Not Depend on NANOG [PDF]
Cells, 2021 The role of the pluripotency factor NANOG during the second embryonic lineage differentiation has been studied extensively in mouse, although species-specific differences exist.
Claudia Springer +3 more
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Context-Dependent Functions of NANOG Phosphorylation in Pluripotency and Reprogramming [PDF]
Stem Cell Reports, 2017 The core pluripotency transcription factor NANOG is critical for embryonic stem cell (ESC) self-renewal and somatic cell reprogramming. Although NANOG is phosphorylated at multiple residues, the role of NANOG phosphorylation in ESC self-renewal is ...
Arven Saunders +10 more
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ZMYM2 inhibits NANOG-mediated reprogramming [PDF]
Wellcome Open Research, 2019 Background: NANOG is a homeodomain-containing transcription factor which forms one of the hubs in the pluripotency network and plays a key role in the reprogramming of somatic cells and epiblast stem cells to naïve pluripotency.
Lawrence, Moyra +4 more
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Esrrb Complementation Rescues Development of Nanog-Null Germ Cells [PDF]
Cell Reports, 2018 Summary: The transcription factors (TFs) Nanog and Esrrb play important roles in embryonic stem cells (ESCs) and during primordial germ-cell (PGC) development.
Man Zhang +8 more
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Nanog structure and simulation setup. [PDF]
, 2023 (A) Human Nanog sequence. NTD, N-terminal domain; DBD, DNA-binding domain; CTD, C-terminal domain; WR, tryptophan-repeated region. The amino acid sequence in WR is depicted. (B) Charged resides in Nanog.
Cheng Tan (293674) +3 more
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Mutant Nanog simulations. [PDF]
, 2023 (A–C) Simulation results for the Nanog mutant W8A. (A) Time course of 200 Nanog molecules along the z-axis (long axis) of the slab. (B) Snapshot at the end of the simulation. (C) Density of amino acids along the z-axis. Yellow, W8A; blue, WT.
Cheng Tan (293674) +3 more
core +1 more source
Biology Open, 2021 The development of three-dimensional cell culture techniques has allowed cancer researchers to study the stemness properties of cancer cells in in vitro culture.
Katherine K. Slemmons +8 more
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