Results 11 to 20 of about 70,422 (295)

The roles of NANOG in tumorigenesis [PDF]

Molecular & Cellular Oncology, 2018
The pluripotency factor Nanog is highly expressed in pluripotent stem cells and certain adult stem cells, but is not expressed in normal adult cells. However, Nanog is frequently overexpressed in human cancers.
Jinchul Kim, Stefan Yu, Yang Xu
doaj   +3 more sources

NaNog: A pluripotency homeobox (master) molecule. [PDF]

Global Cardiology Science and Practice, 2015
One of the most intriguing aspects of cell biology is the state of pluripotency, where the cell is capable of self-renewal for as many times as deemed necessary , then at a specified time can differentiate into any type of cell. This fundamental process
Aguib, YE, Allouba, MH, ElGuindy, AM, Krishnamoorthy, N, Yacoub, MH   +4 more
core   +4 more sources

NANOG Gene [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources

Nanog Heterogeneity: Tilting at Windmills? [PDF]

Cell Stem Cell, 2013
Fluctuating expression of transcription factors in embryonic stem cells is an alluring observation, but, as outlined by two articles in this issue, appearances can be misleading.
Austin Smith
openalex   +3 more sources

NANOG (Nanog homeobox) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on NANOG (Nanog homeobox), with data on DNA, on the protein encoded, and where the gene is implicated.
Schorle, H, Nettersheim, D
openaire   +2 more sources

Role for Med12 in Regulation of Nanog and Nanog Target Genes [PDF]

Journal of Biological Chemistry, 2009
Nanog, Oct4, and Sox2 form the core of a transcription factor network that maintains embryonic stem cells in the pluripotent state in both humans and mice. These critical factors have been implicated as both positive and negative regulators of transcription, varying by promoter and differentiation state of the cell.
Antonin V, Tutter, Michael P, Kowalski, Gretchen A, Baltus, Vadim, Iourgenko, Mark, Labow, En, Li, Shilpa, Kadam   +6 more
openaire   +2 more sources

A NANOG‐pERK reciprocal regulatory circuit regulates Nanog autoregulation and ERK signaling dynamics [PDF]

EMBO reports, 2021
The self-renewal and differentiation potential of Embryonic stem cells (ESCs) is maintained by the regulated expression of core pluripotency factors. The expression level of core pluripotency factor Nanog is tightly regulated by a negative feedback autorepression loop.
Hanuman T Kale, Rajendra Singh Rajpurohit, Debabrata Jana, Vijay V Vishnu, Mansi Srivastava, Preeti R Mourya, Gunda Srinivas, P Chandra Shekar   +7 more
openaire   +2 more sources

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal [PDF]

, 2013
Embryonic stem (ES) cell self-renewal efficiency is determined by the Nanog protein level. However, the protein partners of Nanog that function to direct self-renewal are unclear.
Alessia Gagliardi, Ambrosetti DC, Ambrosetti DC, Anastasia Felker, Anastasia I Kousa, Avilion AA, Bailey TL, Bogan AA, Brookes E, Chambers I, Chambers I, Chen X, Chen X, Costa Y, DeLano WL, Dignam JD, Douglas Colby, Engelen E, Favaro R, Festuccia N, Fidalgo M, Florian Halbritter, Gao Z, Genzor CG, Halbritter F, Han JD, Harley VR, Hatano SY, Ho SN, Hooper M, Hutchins AP, Ian Chambers, Jang H, Jason T Weiss, Jauch R, Jepsen K, Jeroen Demmers, Karel Bezstarosti, Kim J, Laemmli UK, Lam CS, Liang J, Ma T, Marson A, Maruyama M, Masui S, McDonel P, Mitsui K, Moretto-Zita M, Mullin NP, Navarro P, Navarro P, Nicholas P Mullin, Noble SM, Pardo M, Parisi S, Perkins DN, Qin J, Raymond A Poot, Rebecca Favaro, Remenyi A, Reynolds N, Rogers MS, Rugg-Gunn PJ, Shi W, Silvia K Nicolis, Simon R Tomlinson, Singh AM, Smith AG, Surface LE, Ura H, van den Berg DL, Wang J, Wang Z, Whyte WA, Wu Q, Yates A, Yuan H, Zappone MV, Zi Ying Tan   +79 more
core   +1 more source

In silico prediction of the transcription factor-enhancer interaction as a first stage of axonal growth regulation

Сеченовский вестник, 2023
The development of neurodegenerative diseases is associated with proper neuronal circuit formation, axonal guidance. The DCC receptor (deleted in colorectal cancer / colorectal cancer suppressor) and SHH (sonic hedgehog protein) are among the key ...
D. D. Kotelnikov, I. A. Sinyakin, E. A. Borodin, T. A. Batalova   +3 more
doaj   +1 more source

Identification of Nanog as a novel inhibitor of Rad51 [PDF]

Cell Death & Disease, 2022
AbstractTo develop inhibitors targeting DNA damage repair pathways is important to improve the effectiveness of chemo- and radiotherapy for cancer patients. Rad51 mediates homologous recombination (HR) repair of DNA damages. It is widely overexpressed in human cancers and overwhelms chemo- and radiotherapy-generated DNA damages through enhancing HR ...
Ying Xin, Juanjuan Wang, Yahong Wu, Qianqian Li, Mingyang Dong, Chang Liu, Qijia He, Ruifeng Wang, Dian Wang, Sen Jiang, Wei Xiao, Yang Tian, Weiwei Zhang   +12 more
openaire   +3 more sources