Results 11 to 20 of about 11,262 (208)
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on NANOG (Nanog homeobox), with data on DNA, on the protein encoded, and where the gene is implicated.
Schorle, H, Nettersheim, D
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Role for Med12 in Regulation of Nanog and Nanog Target Genes [PDF]
Journal of Biological Chemistry, 2009 Nanog, Oct4, and Sox2 form the core of a transcription factor network that maintains embryonic stem cells in the pluripotent state in both humans and mice. These critical factors have been implicated as both positive and negative regulators of transcription, varying by promoter and differentiation state of the cell.
Antonin V, Tutter +6 more
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Esrrb Is a Direct Nanog Target Gene that Can Substitute for Nanog Function in Pluripotent Cells [PDF]
Cell Stem Cell, 2012 Embryonic stem cell (ESC) self-renewal efficiency is determined by the level of Nanog expression. However, the mechanisms by which Nanog functions remain unclear, and in particular, direct Nanog target genes are uncharacterized. Here we investigate ESCs expressing different Nanog levels and Nanog(-/-) cells with distinct functionally inducible Nanog ...
Festuccia, Nicola +9 more
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The roles of NANOG in tumorigenesis [PDF]
Molecular & Cellular Oncology, 2018 The pluripotency factor Nanog is highly expressed in pluripotent stem cells and certain adult stem cells, but is not expressed in normal adult cells. However, Nanog is frequently overexpressed in human cancers.
Jinchul Kim, Stefan Yu, Yang Xu
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Hypoblast Formation in Bovine Embryos Does Not Depend on NANOG
Cells, 2021 The role of the pluripotency factor NANOG during the second embryonic lineage differentiation has been studied extensively in mouse, although species-specific differences exist.
Claudia Springer +3 more
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Genomics, 2004 Nanog is a recently discovered ANTP class homeobox gene. Mouse Nanog is expressed in the inner cell mass and in embryonic stem cells and has roles in self-renewal and maintenance of pluripotency. Here we describe the location, genomic organization, and relative ages of all human NANOG pseudogenes, comprising ten processed pseudogenes and one tandem ...
Booth, H, Holland, P
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Esrrb Complementation Rescues Development of Nanog-Null Germ Cells [PDF]
Cell Reports, 2018 Summary: The transcription factors (TFs) Nanog and Esrrb play important roles in embryonic stem cells (ESCs) and during primordial germ-cell (PGC) development.
Man Zhang +8 more
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Nanog Is the Gateway to the Pluripotent Ground State [PDF]
Cell, 2009 Pluripotency is generated naturally during mammalian development through formation of the epiblast, founder tissue of the embryo proper. Pluripotency can be recreated by somatic cell reprogramming. Here we present evidence that the homeodomain protein Nanog mediates acquisition of both embryonic and induced pluripotency.
Silva, Jose +9 more
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Anti-Metastatic Function of Extracellular Vesicles Derived from Nanog-Overexpressing Melanoma
Current Oncology, 2022 A metastatic melanoma cell line B16-F10 (F10) was modified to a more undifferentiated state by Nanog overexpression. The produced cell line Nanog+F10 showed a higher metastatic potential than F10.
Tomohiro Hatakenaka +4 more
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A sister of NANOG regulates genes expressed in pre-implantation human development [PDF]
Open Biology, 2017 The NANOG homeobox gene plays a pivotal role in self-renewal and maintenance of pluripotency in human, mouse and other vertebrate embryonic stem cells, and in pluripotent cells of the blastocyst inner cell mass.
Thomas L. Dunwell, Peter W. H. Holland
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