Results 1 to 10 of about 62,870 (256)

Assessing kidney development and disease using kidney organoids and CRISPR engineering

Frontiers in Cell and Developmental Biology, 2022
The differentiation of human pluripotent stem cells (hPSCs) towards organoids is one of the biggest scientific advances in regenerative medicine. Kidney organoids have not only laid the groundwork for various organ-like tissue systems but also provided ...
Wajima Safi, Andrés Marco, Daniel Moya, Patricia Prado, Elena Garreta, Nuria Montserrat, Nuria Montserrat, Nuria Montserrat   +7 more
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Harnessing mechanobiology for kidney organoid research

Frontiers in Cell and Developmental Biology, 2023
Recently, organoids have emerged as revolutionizing tools with the unprecedented potential to recreate organ-specific microanatomy in vitro. Upon their derivation from human pluripotent stem cells (hPSCs), organoids reveal the blueprints of human ...
Zarina Nauryzgaliyeva, Iphigénie Goux Corredera, Elena Garreta, Nuria Montserrat, Nuria Montserrat, Nuria Montserrat   +5 more
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Limited in vitro differentiation of porcine induced pluripotent stem cells into endothelial cells

Journal of Animal Reproduction and Biotechnology, 2023
Background: Pluripotent stem cells (PSCs) including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) offer the immense therapeutic potential in stem cell-based therapy of degenerative disorders.
In-Won Lee, Hyeon-Geun Lee, Dae-Ky Moon, Yeon-Ji Lee, Bo-Gyeong Seo, Sang-Ki Baek, Tae-Suk Kim, Cheol Hwangbo, Joon-Hee Lee   +8 more
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Hybridization led to a rewired pluripotency network in the allotetraploid Xenopus laevis

eLife, 2023
After fertilization, maternally contributed factors to the egg initiate the transition to pluripotency to give rise to embryonic stem cells, in large part by activating de novo transcription from the embryonic genome.
Wesley A Phelps, Matthew D Hurton, Taylor N Ayers, Anne E Carlson, Joel C Rosenbaum, Miler T Lee   +5 more
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Differential Expression Pattern of linc-ROR Spliced Variants in Pluripotent and Non-Pluripotent Cell Lines [PDF]

Cell Journal, 2022
Objective: The human large intergenic non-coding RNA-regulator of reprogramming program (linc-ROR) is known as astem cell specific linc-RNA. linc-ROR counteracts differentiation via sequestering microRNA-145 (miR-145) that targets OCT4 transcript ...
Fatemeh Mirzadeh Azad, Elham Taheri Bajgan, Parisa Naeli, Alexander Rudov, Mahrokh Bagheri Moghadam, Mozhgan Sadat Akhtar, Akram Gholipour, Seyed Javad Mowla, Mahshid Malakootian   +8 more
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Identification of ALPPL2 as a Naive Pluripotent State-Specific Surface Protein Essential for Human Naive Pluripotency Regulation

Cell Reports, 2020
Summary: Human naive pluripotent stem cells established from the epiblasts of preimplantation blastocysts provide a useful model for mechanistic studies of pluripotency regulation and lineage differentiation. Important advances have been made to optimize
Yan Bi, Zhifen Tu, Yanping Zhang, Peng Yang, Mingyue Guo, Xuehao Zhu, Chengchen Zhao, Jianfeng Zhou, Hong Wang, Yixuan Wang, Shaorong Gao   +10 more
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Pressure-induced changes on the morphology and gene expression in mammalian cells

Biology Open, 2021
We evaluated the effect of high hydrostatic pressure on mouse embryonic fibroblasts (MEFs) and mouse embryonic stem (ES) cells. Hydrostatic pressures of 15, 30, 60, and 90 MPa were applied for 10 min, and changes in gene expression were evaluated.
Kazuko Okamoto, Tomonobu M. Watanabe, Masanobu Horie, Masayoshi Nishiyama, Yoshie Harada, Hideaki Fujita   +5 more
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Neural induction drives body axis formation during embryogenesis, but a neural induction-like process drives tumorigenesis in postnatal animals

Frontiers in Cell and Developmental Biology, 2023
Characterization of cancer cells and neural stem cells indicates that tumorigenicity and pluripotency are coupled cell properties determined by neural stemness, and tumorigenesis represents a process of progressive loss of original cell identity and gain
Ying Cao, Ying Cao, Ying Cao
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Generation and cardiac subtype-specific differentiation of PITX2-deficient human iPS cell lines for exploring familial atrial fibrillation

Stem Cell Research, 2017
Loss-of-function mutations in the PITX2 transcription factor gene have been shown to cause familial atrial fibrillation (AF). To potentially model aspects of AF and unravel PITX2-regulated downstream genes for drug target discovery, we here report the ...
Maike Marczenke, Jakob Fell, Ilaria Piccini, Albrecht Röpke, Guiscard Seebohm, Boris Greber   +5 more
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Pluripotential Risk and Clinical Staging: Theoretical Considerations and Preliminary Data From a Transdiagnostic Risk Identification Approach

Frontiers in Psychiatry, 2021
Most psychiatric disorders develop during adolescence and young adulthood and are preceded by a phase during which attenuated or episodic symptoms and functional decline are apparent. The introduction of the ultra-high risk (UHR) criteria two decades ago
Jessica A. Hartmann, Jessica A. Hartmann, Patrick D. McGorry, Patrick D. McGorry, Louise Destree, G. Paul Amminger, G. Paul Amminger, Andrew M. Chanen, Andrew M. Chanen, Christopher G. Davey, Christopher G. Davey, Christopher G. Davey, Rachid Ghieh, Rachid Ghieh, Andrea Polari, Andrea Polari, Aswin Ratheesh, Aswin Ratheesh, Hok Pan Yuen, Hok Pan Yuen, Barnaby Nelson, Barnaby Nelson   +21 more
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