Results 41 to 50 of about 62,870 (256)
Cells, 2022 Pluripotency maintenance and exit in embryonic stem cells is a focal topic in stem cell biology. However, the effects of screening under very stringent culture conditions (e.g., differentiation medium, no leukemia inhibitory factor, no chemical ...
Chen Gao +9 more
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A Pluripotency Platform for Prdm14 [PDF]
Developmental Cell, 2016 The tripartite network of Prdm14, Blimp1, and AP2γ is essential for the important process of germ cell specification, but their precise molecular mechanisms of action remain lacking. Tu and colleagues (2016) report in Nature that the transcriptional co-repressor CBFA2T2 is an essential interactor protein regulating PRDM14 function, shedding light into ...
Burton, Adam +1 more
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An Endogenously Tagged Fluorescent Fusion Protein Library in Mouse Embryonic Stem Cells
Stem Cell Reports, 2017 Embryonic stem cells (ESCs), with their dual capacity to self-renew and differentiate, are commonly used to study differentiation, epigenetic regulation, lineage choices, and more. Using non-directed retroviral integration of a YFP/Cherry exon into mouse
Arigela Harikumar +11 more
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The Epigenome in Pluripotency and Differentiation [PDF]
Epigenomics, 2014 The ability to culture pluripotent stem cells and direct their differentiation into specific cell types in vitro provides a valuable experimental system for modeling pluripotency, development and cellular differentiation. High-throughput profiling of the transcriptomes and epigenomes of pluripotent stem cells and their differentiated derivatives has ...
Thiagarajan, Rathi D +2 more
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Stem Cell Reports, 2017 Promyelocytic leukemia protein (PML), the main constituent of PML nuclear bodies, regulates various physiological processes in different cell types. However, little is known about its functions in embryonic stem cells (ESC).
Christiana Hadjimichael +7 more
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Frontiers in Oncology, 2014 The striking similarity displayed at the mechanistic level between tumorigenesis and the generation of induced pluripotent stem cells and the fact that genes and pathways relevant for embryonic development are reactivated during tumor progression ...
Juan Manuel eIglesias +20 more
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BCMA (TNFRSF17) Induces APRIL and BAFF Mediated Breast Cancer Cell Stemness
Frontiers in Oncology, 2018 Recent advances in cancer immunology revealed immune-related properties of cancer cells as novel promising therapeutic targets. The two TNF superfamily members, APRIL (TNFSF13), and BAFF (TNFSF13B), which are type II membrane proteins, released in active
Vasiliki Pelekanou +12 more
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Repressing Ago2 mRNA translation by Trim71 maintains pluripotency through inhibiting let-7 microRNAs
eLife, 2021 The regulation of stem cell fate is poorly understood. Genetic studies in Caenorhabditis elegans lead to the hypothesis that a conserved cytoplasmic double-negative feedback loop consisting of the RNA-binding protein Trim71 and the let-7 microRNA ...
Qiuying Liu +4 more
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Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells
eLife, 2022 The transcription factor Oct4 is essential for the maintenance and induction of stem cell pluripotency, but its functional roles are not fully understood.
Le Xiong +10 more
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Connecting the DOTs on Cell Identity
Frontiers in Cell and Developmental Biology, 2022 DOT1-Like (DOT1L) is the sole methyltransferase of histone H3K79, a modification enriched mainly on the bodies of actively transcribing genes. DOT1L has been extensively studied in leukemia were some of the most frequent onco-fusion proteins contain ...
Coral K. Wille +2 more
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