Results 61 to 70 of about 83,579 (259)

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

FGF2 supports NANOG expression via pyruvate dehydrogenase–dependent histone acetylation under low oxygen conditions

Frontiers in Cell and Developmental Biology
IntroductionThe safe and effective application of human pluripotent stem cells (hPSCs) in research and regenerative medicine requires precise control over pluripotency and cell fate.
Petr Fojtík, Petr Fojtík, Petr Fojtík, Martin Senfluk, Katerina Holomkova, Anton Salykin, Jana Gregorova, Pavel Smak, Ondrej Pes, Jan Raska, Jan Raska, Deborah Beckerova, Deborah Beckerova, Monika Stetkova, Petr Skladal, Miroslava Sedlackova, Ales Hampl, Ales Hampl, Dasa Bohaciakova, Dasa Bohaciakova, Stjepan Uldrijan, Stjepan Uldrijan, Vladimir Rotrekl, Vladimir Rotrekl   +23 more
doaj   +1 more source

Reconstruction, visualization and explorative analysis of human pluripotency network [PDF]

, 2017
Identification of genes/proteins involved in pluripotency and their inter-relationships is important for understanding the induction/loss and maintenance of pluripotency.
Priyanka Narad, Anup Som, Kailash C.Upadhyaya   +2 more
core   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Non-coding RNAs in pluripotency and neural differentiation of human pluripotent stem cells

Frontiers in Genetics, 2014
Several studies have demonstrated the important role of non-coding RNAs as regulators of posttranscriptional processes, including stem cells self-renewal and neural differentiation.
Dunja eLukovic, Victoria eMoreno-Manzano, Martin eKlabusay, Miodrag eStojkovic, Miodrag eStojkovic, Shomi S Bhattacharya, SLAVEN eERCEG   +6 more
doaj   +1 more source

BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells

Advanced Science, EarlyView.
BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li, Nana Zhang, Zexin Bian, Baobao Geng, Liyun Cao, Peipei Liu, Zengming Li, Yan Zhao, Jun Tan   +8 more
wiley   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Inheritance of OCT4 predetermines fate choice in human embryonic stem cells

Molecular Systems Biology, 2018
It is well known that clonal cells can make different fate decisions, but it is unclear whether these decisions are determined during, or before, a cell's own lifetime.
Samuel C Wolff, Katarzyna M Kedziora, Raluca Dumitru, Cierra D Dungee, Tarek M Zikry, Adriana S Beltran, Rachel A Haggerty, JrGang Cheng, Margaret A Redick, Jeremy E Purvis   +9 more
doaj   +1 more source

Protein Kinases in Pluripotency - Beyond the Usual Suspects [PDF]

, 2017
Post-translational modification of proteins by phosphorylation plays a key role in regulating all aspects of eukaryotic biology. Embryonic Stem Cell (ESC) pluripotency, defined as the ability to differentiate into all cell types in the adult body, is no ...
Williams, Charles A. C., Findlay, Greg M., Fernandez-Alonso, Rosalia, Bustos, Francisco, Charles A.C. Williams, Greg M. Findlay, Francisco Bustos, Rosalia Fernandez-Alonso   +7 more
core   +1 more source

Profiling mitochondria-polyribosome lncRNAs associated with pluripotency

, 2023
Pluripotent stem cells (PSCs) provide unlimited resources for regenerative medicine because of their potential for self-renewal and differentiation into many different cell types.
Ji-Fan Hu, Andrew R. Hoffman, Xue Wen, Miguel A. Esteban, Min Li, Chao Niu, Wei Li, Jiuwei Cui, Tingge Sun, Lei Zhou, Hui Li   +10 more
core   +1 more source