Results 61 to 70 of about 111,548 (274)
Snapshots of Pluripotency [PDF]
Stem Cell Reports, 2016 Pluripotency is a unique developmental state that lays the foundation upon which the entire embryo is built. Pluripotent cells possess the unique capacity to generate, in an exquisitely defined sequence, all the distinct cell types comprising the fetal and adult organism. The discovery of pluripotent stem cells and now the ability to generate them from
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A Pluripotency Platform for Prdm14 [PDF]
Developmental Cell, 2016 The tripartite network of Prdm14, Blimp1, and AP2γ is essential for the important process of germ cell specification, but their precise molecular mechanisms of action remain lacking. Tu and colleagues (2016) report in Nature that the transcriptional co-repressor CBFA2T2 is an essential interactor protein regulating PRDM14 function, shedding light into ...
Burton, Adam +1 more
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Production and characterization of CSSI003 (2961) human induced pluripotent stem cells (iPSCs) carrying a novel puntiform mutation in RAI1 gene, Causative of Smith–Magenis syndrome [PDF]
, 2018 Smith-Magenis syndrome (SMS) is a complex genetic disorder characterized by developmental delay, behavioural problems and circadian rhythm dysregulation. About 90% of SMS cases are due to a 17p11.2 deletion containing retinoic acid induced1 (RAI1) gene,
Altieri, Filomena +12 more
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Rationale and Methodology of Reprogramming for Generation of Induced Pluripotent Stem Cells and Induced Neural Progenitor Cells. [PDF]
, 2016 Great progress has been made regarding the capabilities to modify somatic cell fate ever since the technology for generation of induced pluripotent stem cells (iPSCs) was discovered in 2006.
Biswas, Sangita +3 more
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Cells, 2022 Pluripotency maintenance and exit in embryonic stem cells is a focal topic in stem cell biology. However, the effects of screening under very stringent culture conditions (e.g., differentiation medium, no leukemia inhibitory factor, no chemical ...
Chen Gao +9 more
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An Endogenously Tagged Fluorescent Fusion Protein Library in Mouse Embryonic Stem Cells
Stem Cell Reports, 2017 Embryonic stem cells (ESCs), with their dual capacity to self-renew and differentiate, are commonly used to study differentiation, epigenetic regulation, lineage choices, and more. Using non-directed retroviral integration of a YFP/Cherry exon into mouse
Arigela Harikumar +11 more
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Stem Cell Reports, 2017 Promyelocytic leukemia protein (PML), the main constituent of PML nuclear bodies, regulates various physiological processes in different cell types. However, little is known about its functions in embryonic stem cells (ESC).
Christiana Hadjimichael +7 more
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The Epigenome in Pluripotency and Differentiation [PDF]
Epigenomics, 2014 The ability to culture pluripotent stem cells and direct their differentiation into specific cell types in vitro provides a valuable experimental system for modeling pluripotency, development and cellular differentiation. High-throughput profiling of the transcriptomes and epigenomes of pluripotent stem cells and their differentiated derivatives has ...
Thiagarajan, Rathi D +2 more
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Frontiers in Oncology, 2014 The striking similarity displayed at the mechanistic level between tumorigenesis and the generation of induced pluripotent stem cells and the fact that genes and pathways relevant for embryonic development are reactivated during tumor progression ...
Juan Manuel eIglesias +20 more
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BCMA (TNFRSF17) Induces APRIL and BAFF Mediated Breast Cancer Cell Stemness
Frontiers in Oncology, 2018 Recent advances in cancer immunology revealed immune-related properties of cancer cells as novel promising therapeutic targets. The two TNF superfamily members, APRIL (TNFSF13), and BAFF (TNFSF13B), which are type II membrane proteins, released in active
Vasiliki Pelekanou +12 more
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