Construction of recombinant sox2-encoding plasmids that regulate pluripotency of breast cancer stem cells from indonesian patient [PDF]
Pharmaciana, 2019 A therapy development with recombinant protein is a new and potential innovation to destroy cancer stem cells (CSCs). Various ways of killing CSCs include the provision of polyvalent anti-protein antibodies that code pluripotency.
Hanifah Rahmi +3 more
doaj +1 more source
Co-expression networks in generation of induced pluripotent stem cells. [PDF]
, 2016 We developed an adenoviral vector, in which Yamanaka's four reprogramming factors (RFs) were controlled by individual CMV promoters in a single cassette (Ad-SOcMK). This permitted coordinated expression of RFs (SOX2, OCT3/4, c-MYC and KLF4) in a cell for
Coppola, Giovanni +6 more
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NANOG expression in parthenogenetic porcine blastocysts is required for intact lineage specification and pluripotency [PDF]
Animal Bioscience, 2023 Objective Nanog homeobox (NANOG) is a core transcription factor that contributes to pluripotency along with octamer binding transcription factor-4 (OCT4) and sex determining region-Y box-2 (SOX2).
Mingyun Lee +8 more
doaj +1 more source
A stochastic model dissects cell states in biological transition processes [PDF]
, 2013 Many biological processes, including differentiation, reprogramming, and disease transformations, involve transitions of cells through distinct states.
Armond, Jonathan W. +6 more
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Statistical Mechanics of Pluripotency [PDF]
Cell, 2013 Recent reports using single-cell profiling have indicated a remarkably dynamic view of pluripotent stem cell identity. Here, we argue that the pluripotent state is not well defined at the single-cell level but rather is a statistical property of stem cell populations, amenable to analysis using the tools of statistical mechanics and information theory.
MacArthur, Ben D., Lemischka, Ihor R.
openaire +3 more sources
Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [PDF]
, 2006 The POU domain transcription factor OCT4 is a key regulator of pluripotency in the early mammalian embryo and is highly expressed in the inner cell mass of the blastocyst. Consistent with its essential role in maintaining pluripotency, Oct4 expression is
Adjaye, J. +8 more
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Epigenetics of Pluripotent Cells [PDF]
Acta Naturae, 2012 Pluripotency is maintained by a complex system that includes the genetic and epigenetic levels. Recent studies have shown that the genetic level (transcription factors, signal pathways, and microRNAs) closely interacts with the enzymes and other specific proteins that participate in the formation of the chromatin structure.
Medvedev, S., Pokushalov, E., Zakian, S.
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Organization of the Pluripotent Genome [PDF]
Cold Spring Harbor Perspectives in Biology, 2020 In the past several decades, the establishment of in vitro models of pluripotency has ushered in a golden era for developmental and stem cell biology. Research in this arena has led to profound insights into the regulatory features that shape early embryonic development.
Lim, Patrick S.L., Meshorer, Eran
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microRNA-mediated regulation of microRNA machinery controls cell fate decisions
eLife, 2021 microRNAs associate with Argonaute proteins, forming the microRNA-induced silencing complex (miRISC), to repress target gene expression post-transcriptionally.
Qiuying Liu +4 more
doaj +1 more source
Investigating the functionality of an OCT4-short response element in human induced pluripotent stem cells. [PDF]
, 2016 Pluripotent stem cells offer great therapeutic promise for personalized treatment platforms for numerous injuries, disorders, and diseases. Octamer-binding transcription factor 4 (OCT4) is a key regulatory gene maintaining pluripotency and self-renewal ...
Awe, Jason P +9 more
core +3 more sources