Results 71 to 80 of about 83,579 (259)

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

A competitive protein interaction network buffers Oct4‐mediated differentiation to promote pluripotency in embryonic stem cells

Molecular Systems Biology, 2013
Pluripotency in embryonic stem cells is maintained through the activity of a small set of transcription factors centred around Oct4 and Nanog, which control the expression of ‘self‐renewal’ and ‘differentiation’ genes.
Silvia Muñoz Descalzo, Pau Rué, Fernando Faunes, Penelope Hayward, Lars Martin Jakt, Tina Balayo, Jordi Garcia‐Ojalvo, Alfonso Martinez Arias   +7 more
doaj   +1 more source

Chaperones and Beyond as Key Players in Pluripotency Maintenance

Frontiers in Cell and Developmental Biology, 2019
Pluripotency is orchestrated by distinct players and chaperones and their partners have emerged as pivotal molecules in proteostasis control to maintain stemness.
Camila Felix de Lima Fernandes, Rebeca Piatniczka Iglesia, Maria Isabel Melo-Escobar, Mariana Brandão Prado, Marilene Hohmuth Lopes   +4 more
doaj   +1 more source

Formative pluripotency: the executive phase in a developmental continuum. [PDF]

, 2017
The regulative capability of single cells to give rise to all primary embryonic lineages is termed pluripotency. Observations of fluctuating gene expression and phenotypic heterogeneity in vitro have fostered a conception of pluripotency as an ...

core   +2 more sources

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

Advanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao, Ting‐Yu Han, Yan‐Li Cheng, Yi‐Dan Zhang, Yu‐Wei Zhang, JinJian Guo, ShaoJun Zhang, WenZe Huang, Jing Zhang, Pei‐Yu Liao, Ying Xin, ChuanChen Chu, Qing‐Yuan Sun, ZhiZhen Liu, Xiang‐Hong Ou, Jun Xie   +15 more
wiley   +1 more source

A Dynamic Role of TBX3 in the Pluripotency Circuitry

, 2015
Pluripotency represents a cell state comprising a fine-tuned pattern of transcription factor activity required for embryonic stem cell (ESC) self-renewal.
Thomas Seufferlein, Anett Illing, Pavan Kumar P., Lechel, André, Wu, Guangming, Qiong Lin, Stefan Liebau, Martin Zenke, Guangming Wu, Sakk, Olena, Moon, Anne, Moritz Klingenstein, Schöler, Hans R., Ronan Russell, Kenjiro Adachi, Russell, Ronan, Ilg, Marcus, Bergmann, Wendy, Wendy Bergmann, Stefanie Raab, Alexander Kleger, Lin, Qiong, Seufferlein, Thomas, Eiseler, Tim, Meike Hohwieler, Zenke, Martin, Linta, Leonhard, André Lechel, Klingenstein, Moritz, Leonhard Linta, Tim Eiseler, Kleger, Alexander, Anne Moon, Hohwieler, Meike, Olena Sakk, Liebau, Stefan, Kumar P, Pavan, Illing, Anett, Adachi, Kenjiro, Marcus Ilg, Raab, Stefanie, Hans R. Schöler   +41 more
core   +1 more source

Pluripotency Factors on Their Lineage Move [PDF]

, 2016
Pluripotent stem cells are characterised by continuous self-renewal while maintaining the potential to differentiate into cells of all three germ layers.
Thomas Seufferlein, Clair E. Weidgang, Martin Mueller, Alexander Kleger   +3 more
core   +1 more source

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

Induced Pluripotent Stem Cell Neuronal Models for the Study of Autophagy Pathways in Human Neurodegenerative Disease

Cells, 2017
Human induced pluripotent stem cells (hiPSCs) are invaluable tools for research into the causes of diverse human diseases, and have enormous potential in the emerging field of regenerative medicine.
Natalia Jiménez-Moreno, Petros Stathakos, Maeve A. Caldwell, Jon D. Lane   +3 more
doaj   +1 more source

Deriving bovine embryonic stem-like cells in defined conditions [PDF]

, 2011
The first embryonic stem ES cell line was isolated from mouse in 1981 (Evans and Kaufman 1981; Martin1981). However, ESCs are only available in rodent species.
Muhammad Alahdal, Hadil, Hadil Muhammad Alahdal   +1 more
core