Results 71 to 80 of about 111,548 (274)

Repressing Ago2 mRNA translation by Trim71 maintains pluripotency through inhibiting let-7 microRNAs

eLife, 2021
The regulation of stem cell fate is poorly understood. Genetic studies in Caenorhabditis elegans lead to the hypothesis that a conserved cytoplasmic double-negative feedback loop consisting of the RNA-binding protein Trim71 and the let-7 microRNA ...
Qiuying Liu, Xiaoli Chen, Mariah K Novak, Shaojie Zhang, Wenqian Hu   +4 more
doaj   +1 more source

Reference loci for RT-qPCR analysis of differentiating human embryonic stem cells [PDF]

, 2013
Background: Selecting stably expressed reference genes is essential for proper reverse transcription quantitative polymerase chain reaction gene expression analysis. However, this choice is not always straightforward. In the case of differentiating human
De Sutter, Petra, Deforce, Dieter, Heindryckx, Björn, O'Leary, Thomas, Van Neste, Christophe, Vandesompele, Jo, Vossaert, Liesbeth   +6 more
core   +2 more sources

Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells

eLife, 2022
The transcription factor Oct4 is essential for the maintenance and induction of stem cell pluripotency, but its functional roles are not fully understood.
Le Xiong, Erik A Tolen, Jinmi Choi, Sergiy Velychko, Livia Caizzi, Taras Velychko, Kenjiro Adachi, Caitlin M MacCarthy, Michael Lidschreiber, Patrick Cramer, Hans R Schöler   +10 more
doaj   +1 more source

Connecting the DOTs on Cell Identity

Frontiers in Cell and Developmental Biology, 2022
DOT1-Like (DOT1L) is the sole methyltransferase of histone H3K79, a modification enriched mainly on the bodies of actively transcribing genes. DOT1L has been extensively studied in leukemia were some of the most frequent onco-fusion proteins contain ...
Coral K. Wille, Rupa Sridharan, Rupa Sridharan   +2 more
doaj   +1 more source

Direct comparison of distinct naive pluripotent states in human embryonic stem cells [PDF]

, 2017
Until recently, human embryonic stem cells (hESCs) were shown to exist in a state of primed pluripotency, while mouse embryonic stem cells (mESCs) display a naive or primed pluripotent state.
Chuva de Sousa Lopes, Susana Marina, De Coninck, Dieter, De Sutter, Petra, Deforce, Dieter, Duggal, Galbha, Heindryckx, Björn, Lierman, Sylvie, Menten, Björn, Mestdagh, Pieter, Peelman, Luc, Popovic, Mina, Sutherland, Ella, Taelman, Jasin, Tilleman, Laurentijn, Van der Jeught, Margot, Van Nieuwerburgh, Filip, Van Soom, Ann, Vandesompele, Jo, Warrier, Sharat   +18 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

A stochastic and dynamical view of pluripotency in mouse embryonic stem cells

, 2017
Pluripotent embryonic stem cells are of paramount importance for biomedical research thanks to their innate ability for self-renewal and differentiation into all major cell lines.
Hufton, Peter G., Lee, Esther J., Lin, Yen Ting, Potoyan, Davit A.   +3 more
core   +6 more sources

The thyroid hormone enhances mouse embryonic fibroblasts reprogramming to pluripotent stem cells: role of the nuclear receptor corepressor 1

Frontiers in Endocrinology, 2023
IntroductionPluripotent stem cells can be generated from somatic cells by the Yamanaka factors Oct4, Sox2, Klf4 and c-Myc.MethodsMouse embryonic fibroblasts (MEFs) were transduced with the Yamanaka factors and generation of induced pluripotent stem cells
Constanza Contreras-Jurado, Constanza Contreras-Jurado, Constanza Contreras-Jurado, Ana Montero-Pedrazuela, Raúl F. Pérez, Raúl F. Pérez, Raúl F. Pérez, Raúl F. Pérez, Raúl F. Pérez, Susana Alemany, Mario F. Fraga, Mario F. Fraga, Mario F. Fraga, Mario F. Fraga, Mario F. Fraga, Ana Aranda, Ana Aranda   +16 more
doaj   +1 more source

Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis [PDF]

, 2016
Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage.
Toofan, Parto, Wheadon, Helen
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source