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Derivation of multipotent mesenchymal precursors from human embryonic stem cells. [PDF]
PLoS Medicine, 2005 BACKGROUND: Human embryonic stem cells provide access to the earliest stages of human development and may serve as a source of specialized cells for regenerative medicine.
Tiziano Barberi +3 more
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Reprogramming Malignant Cancer Cells toward a Benign Phenotype following Exposure to Human Embryonic Stem Cell Microenvironment. [PDF]
PLoS ONE, 2017 The embryonic microenvironment is well known to be non-permissive for tumor development because early developmental signals naturally suppress the expression of proto-oncogenes.
Shufeng Zhou +4 more
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An in vitro stem cell model of human epiblast and yolk sac interaction
eLife, 2021 Human embryogenesis entails complex signalling interactions between embryonic and extra-embryonic cells. However, how extra-embryonic cells direct morphogenesis within the human embryo remains largely unknown due to a lack of relevant stem cell models ...
Kirsty ML Mackinlay +10 more
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Non-human primate pluripotent stem cells for the preclinical testing of regenerative therapies
Neural Regeneration Research, 2022 Non-human primates play a key role in the preclinical validation of pluripotent stem cell-based cell replacement therapies. Pluripotent stem cells used as advanced therapy medical products boost the possibility to regenerate tissues and organs affected ...
Ignacio Rodriguez-Polo, Rüdiger Behr
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Stem Cell Research, 2020 Neural crest cells are an embryonic multipotent stem cell population. Recent studies in model organisms have suggested that neural crest cells are specified earlier than previously thought, at blastula stages.
Maneeshi S. Prasad +3 more
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Stem Cell Research & Therapy, 2017 Background Human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells, hold enormous promise for many biomedical applications, such as regenerative medicine, drug testing, and disease modeling.
Elvira Parrotta +13 more
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Porcine OCT4 reporter system as a tool for monitoring pluripotency states
Journal of Animal Reproduction and Biotechnology, 2021 Pluripotent stem cells could self-renew and differentiate into various cells. In particular, porcine pluripotent stem cells are useful for preclinical therapy, transgenic animals, and agricultural usage. These stem cells have naïve and primed pluripotent
Seung-Hun Kim, Chang-Kyu Lee
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Human embryonic stem cells handbook
European Journal of Histochemistry, 2013 After the Nobel prize in physiology or medicine was awarded jointly to Sir John Gurdon and Shinya Yamanaka for the discovery that mature cells can be reprogrammed to become pluripotent it became imperative to write down the review for a book entirely ...
Carlo Alberto Redi
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Transcriptional profiling of ectoderm specification to keratinocyte fate in human embryonic stem cells. [PDF]
PLoS ONE, 2015 In recent years, several studies have shed light into the processes that regulate epidermal specification and homeostasis. We previously showed that a broad-spectrum γ-secretase inhibitor DAPT promoted early keratinocyte specification in human embryonic ...
Ana Mafalda Baptista Tadeu +6 more
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Asynchronous replication and autosome-pair non-equivalence in human embryonic stem cells. [PDF]
PLoS ONE, 2009 A number of mammalian genes exhibit the unusual properties of random monoallelic expression and random asynchronous replication. Such exceptional genes include genes subject to X inactivation and autosomal genes including odorant receptors ...
Devkanya Dutta +3 more
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