Results 11 to 20 of about 466,085 (286)
Autophagy in human embryonic stem cells.
PLoS ONE, 2011 Autophagy (macroautophagy) is a degradative process that involves the sequestration of cytosolic material including organelles into double membrane vesicles termed autophagosomes for delivery to the lysosome.
Thien Tra +7 more
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Epigenetic Regulation of Human Embryonic Stem Cells [PDF]
Frontiers in Genetics, 2012 Recently, there has been tremendous progress in characterizing the transcriptional network regulating hESCs (MacArthur et al., 2009; Loh et al., 2011), including those signaling events mediated by Oct4, Nanog and Sox2.
Qidong eHu, Michael G. Rosenfeld
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Human embryonic stem cells [PDF]
Cell Cycle, 2012 Despite intense investigation on apoptosis pathways, exactly how apoptosis is regulated in various primary cells remains understudied and continues to reveal unexpected mechanisms. While a strict regulation of apoptosis is critical for the long-term survival of postmitotic cells, mitotic cells need to maintain their ability to activate apoptosis ...
Gama, Vivian, Deshmukh, Mohanish
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Human embryonic stem cells handbook
European Journal of Histochemistry, 2013 After the Nobel prize in physiology or medicine was awarded jointly to Sir John Gurdon and Shinya Yamanaka for the discovery that mature cells can be reprogrammed to become pluripotent it became imperative to write down the review for a book entirely ...
Carlo Alberto Redi
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Transcriptional profiling of ectoderm specification to keratinocyte fate in human embryonic stem cells. [PDF]
PLoS ONE, 2015 In recent years, several studies have shed light into the processes that regulate epidermal specification and homeostasis. We previously showed that a broad-spectrum γ-secretase inhibitor DAPT promoted early keratinocyte specification in human embryonic ...
Ana Mafalda Baptista Tadeu +6 more
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Direct comparison of distinct naive pluripotent states in human embryonic stem cells [PDF]
, 2017 Until recently, human embryonic stem cells (hESCs) were shown to exist in a state of primed pluripotency, while mouse embryonic stem cells (mESCs) display a naive or primed pluripotent state.
Chuva de Sousa Lopes, Susana Marina +18 more
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Mechanisms of action of hESC-secreted proteins that enhance human and mouse myogenesis. [PDF]
, 2014 Adult stem cells grow poorly in vitro compared to embryonic stem cells, and in vivo stem cell maintenance and proliferation by tissue niches progressively deteriorates with age.
CONBOY, Irina M +6 more
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Asynchronous replication and autosome-pair non-equivalence in human embryonic stem cells. [PDF]
PLoS ONE, 2009 A number of mammalian genes exhibit the unusual properties of random monoallelic expression and random asynchronous replication. Such exceptional genes include genes subject to X inactivation and autosomal genes including odorant receptors ...
Devkanya Dutta +3 more
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Proteomics of human embryonic stem cells
PROTEOMICS, 2011 AbstractHuman embryonic stem cells (hESCs) offer exciting potential in regenerative medicine for the treatment of a host of diseases including cancer, Alzheimer's and Parkinson's disease. They also provide insight into human development and disease and can be used as models for drug discovery and toxicity analyses. The key properties of hESCs that make
Hughes, Chris S. +3 more
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Human Embryonic Stem Cells [PDF]
Bone Marrow Transplantation, 2004 Abstract In 1981, Evans and Kaufman (1) described the technique for isolating embryonic stem (ES) cell lines from mouse blastocysts. In this procedure, the inner cell mass is used to give rise to an undifferentiated cell line capable of indefinite proliferation in vitro.
Susan E Lanzendorf +2 more
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