Results 21 to 30 of about 12,340,655 (258)

Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways.

PLoS ONE, 2009
Human embryonic stem cells have unique value for regenerative medicine, as they are capable of differentiating into a broad variety of cell types. Therefore, defining the signalling pathways that control early cell fate decisions of pluripotent stem ...
Ludovic Vallier, Thomas Touboul, Zhenzhi Chng, Minodora Brimpari, Nicholas Hannan, Enrique Millan, Lucy E Smithers, Matthew Trotter, Peter Rugg-Gunn, Anne Weber, Roger A Pedersen   +10 more
doaj   +1 more source

Differences in transcription patterns between induced pluripotent stem cells produced from the same germ layer are erased upon differentiation. [PDF]

PLoS ONE, 2013
Little is known about differences between induced pluripotent stem cells produced from tissues originating from the same germ layer. We have generated human myoblast-derived iPS cells by retroviral transduction of human primary myoblasts with the OCT3/4,
Iryna Pirozhkova, Ana Barat, Petr Dmitriev, Elena Kim, Thomas Robert, Justine Guégan, Chrystèle Bilhou-Nabera, Florence Busato, Jörg Tost, Gilles Carnac, Dalila Laoudj-Chenivesse, Marc Lipinski, Yegor Vassetzky   +12 more
doaj   +1 more source

Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]

, 2002
Pluripotent mouse embryonic stem (ES) cells can be expanded in large numbers in vitro owing to a process of symmetrical self-renewal. Self-renewal entails proliferation with a concomitant suppression of differentiation.
Burdon, Tom, Burdon, T., Smith, A., Savatier, Pierre, Smith, Austin   +4 more
core   +1 more source

LSD1 inhibition yields functional insulin-producing cells from human embryonic stem cells

Stem Cell Research & Therapy, 2020
Background Human embryonic stem cells represent a potentially unlimited source of insulin-producing cells for diabetes therapy. While tremendous progress has been made in directed differentiation of human embryonic stem cells into IPCs in vitro, the ...
Fei He, Ning Li, Hai-Bo Huang, Jing-Bo Wang, Xiao-Fei Yang, Hua-Dong Wang, Wei Huang, Fu-Rong Li   +7 more
doaj   +1 more source

Embryos, Clones, and Stem Cells: A Scientific Primer

The Scientific World Journal, 2004
This article is intended to give the nonspecialist an insight into the nuances of “clones”, cloning, and stem cells. It distinguishes embryonic and adult stem cells, their normal function in the organism, their origin, and how they are recovered to ...
Kenyon S. Tweedell
doaj   +1 more source

A subset of mobilized human hematopoietic stem cells express germ layer lineage genes which can be modulated by culture conditions

Stem Cell Research & Therapy, 2018
Background Adult bone marrow contains stem cells that replenish the myeloid and lymphoid lineages. A subset of human and mouse CD34+ bone marrow stem cells can be propagated in culture to autonomously express embryonic stem cell genes and embryonic germ ...
Tapas Makar, Vamshi K. Nimmagadda, Poornachander R. Guda, Brian Hampton, Weiliang Huang, Maureen A. Kane, Paul S. Fishman, Bernard Pessac, Christopher T. Bever, David Trisler   +9 more
doaj   +1 more source

Human embryonic stem cells: preclinical perspectives

Journal of Translational Medicine, 2008
Human embryonic stem cells (hESCs) have been extensively discussed in public and scientific communities for their potential in treating diseases and injuries. However, not much has been achieved in turning them into safe therapeutic agents.
Sarda Kanchan, Deb Kaushik
doaj   +1 more source

Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells [PDF]

, 2015
© 2015 Macmillan Publishers Limited. All rights reserved. microRNA-34a (miR-34a) and sirtuin 1 (SirT1) have been extensively studied in tumour biology and longevityaging, but little is known about their functional roles in smooth muscle cell (SMC ...
L A Luong, Wen, G., Q Chen, Luong, LA, Q Xiao, Zhu, J, Zhu, J., Chen, Q, Y Huang, Luong, L. A., Zhang, L., Ye, S., H Zhao, G Wen, Wang, W, L Zhang, Xu, Q., Yu, X., Wen, G, Xiao, Q, Ye, S, Huang, Y, Q Xu, Zhao, H, X Yu, Huang, Y., Xu, Q, W Wang, Chen, Q., J Zhu, Yu, X, Zhang, L, Wang, W., Xiao, Q., Zhao, H., S Ye   +35 more
core   +1 more source

Autophagy in human embryonic stem cells.

PLoS ONE, 2011
Autophagy (macroautophagy) is a degradative process that involves the sequestration of cytosolic material including organelles into double membrane vesicles termed autophagosomes for delivery to the lysosome.
Thien Tra, Lan Gong, Lin-Pin Kao, Xue-Lei Li, Catarina Grandela, Rodney J Devenish, Ernst Wolvetang, Mark Prescott   +7 more
doaj   +1 more source

Slow Turning Lateral Vessel Bioreactor Improves Embryoid Body Formation and Cardiogenic Differentiation of Mouse Embryonic Stem Cells. [PDF]

, 2013
Embryonic stem cells (ESCs) have the ability to form aggregates, which are called embryoid bodies (EBs). EBs mimic early embryonic development and are commonly produced for cardiomyogenesis.
Tharasanit, T., Biology of Reproductive Cells, Pirity, M., Rungarunlert, Sasitorn, Klincumhom, Nuttha, Rungarunlert, S., Dinnyés, András, Tharasanit, Theerawat, Dep Gezondheidszorg Landbouwhuisdieren, Klincumhom, N., Techakumphu, M., Pirity, Melinda, Dinnyes, A.   +12 more
core   +1 more source