Results 21 to 30 of about 466,085 (286)
Computational analysis of expression of human embryonic stem cell-associated signatures in tumors
BMC Research Notes, 2011 Background The cancer stem cell model has been proposed based on the linkage between human embryonic stem cells and human cancer cells. However, the evidences supporting the cancer stem cell model remain to be collected.
Wang Xiaosheng
doaj +1 more source
Generation of GADD45A gene knockout human embryonic stem cell line using CRISPR/Cas9
Stem Cell Research, 2020 GADD45A is a DNA damage and stressful growth arrest inducible protein, also it is shown to a be tumor suppressor gene and a chromatin relaxer associated with opening chromatin during the somatic reprogramming.
Jinbing Li +7 more
doaj +1 more source
Enhanced differentiation of human embryonic stem cells towards definitive endoderm on ultrahigh aspect ratio nanopillars [PDF]
, 2015 Differentiation of human embryonic stem cells is widely studied as a potential unlimited source for cell replacement therapy to treat degenerative diseases such as diabetes.
Dufva, Martin +6 more
core +2 more sources
PLoS ONE, 2009 Human embryonic stem cells have unique value for regenerative medicine, as they are capable of differentiating into a broad variety of cell types. Therefore, defining the signalling pathways that control early cell fate decisions of pluripotent stem ...
Ludovic Vallier +10 more
doaj +1 more source
Differences in transcription patterns between induced pluripotent stem cells produced from the same germ layer are erased upon differentiation. [PDF]
PLoS ONE, 2013 Little is known about differences between induced pluripotent stem cells produced from tissues originating from the same germ layer. We have generated human myoblast-derived iPS cells by retroviral transduction of human primary myoblasts with the OCT3/4,
Iryna Pirozhkova +12 more
doaj +1 more source
LSD1 inhibition yields functional insulin-producing cells from human embryonic stem cells
Stem Cell Research & Therapy, 2020 Background Human embryonic stem cells represent a potentially unlimited source of insulin-producing cells for diabetes therapy. While tremendous progress has been made in directed differentiation of human embryonic stem cells into IPCs in vitro, the ...
Fei He +7 more
doaj +1 more source
Cells, 2019 A population of small stem cells with diameters of up to 5 μm resembling very small embryonic-like stem cells (VSELs) were sorted from human embryonic stem cell (hESC) cultures using magnetic-activated cell sorting (MACS) based on the expression of ...
Irma Virant-Klun +4 more
doaj +1 more source
Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil [PDF]
, 2018 Purpose of Review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell ...
Aljoufi, Arafat +3 more
core +1 more source
Embryos, Clones, and Stem Cells: A Scientific Primer
The Scientific World Journal, 2004 This article is intended to give the nonspecialist an insight into the nuances of “clones”, cloning, and stem cells. It distinguishes embryonic and adult stem cells, their normal function in the organism, their origin, and how they are recovered to ...
Kenyon S. Tweedell
doaj +1 more source
Stem Cell Research & Therapy, 2018 Background Adult bone marrow contains stem cells that replenish the myeloid and lymphoid lineages. A subset of human and mouse CD34+ bone marrow stem cells can be propagated in culture to autonomously express embryonic stem cell genes and embryonic germ ...
Tapas Makar +9 more
doaj +1 more source