Comparative global immune-related gene profiling of somatic cells, human pluripotent stem cells and their derivatives: implication for human lymphocyte proliferation. [PDF]
, 2017 Human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced PSCs (iPSCs), represent potentially unlimited cell sources for clinical applications. Previous studies have suggested that hPSCs may benefit from immune privilege and
Allard, Patrick +12 more
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Glycosphingolipids of human embryonic stem cells [PDF]
Glycoconjugate Journal, 2016 The application of human stem cell technology offers theoretically a great potential to treat various human diseases. However, to achieve this goal a large number of scientific issues remain to be solved. Cell surface carbohydrate antigens are involved in a number of biomedical phenomena that are important in clinical applications of stem cells, such ...
Breimer, Michael E. +3 more
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Human embryonic stem cells: preclinical perspectives
Journal of Translational Medicine, 2008 Human embryonic stem cells (hESCs) have been extensively discussed in public and scientific communities for their potential in treating diseases and injuries. However, not much has been achieved in turning them into safe therapeutic agents.
Sarda Kanchan, Deb Kaushik
doaj +1 more source
Cancer-associated TERT promoter mutations abrogate telomerase silencing. [PDF]
, 2015 Mutations in the human telomerase reverse transcriptase (TERT) promoter are the most frequent non-coding mutations in cancer, but their molecular mechanism in tumorigenesis has not been established.
Boyle, John +5 more
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Stem Cell Research, 2020 We generated an induced human pluripotent stem cell line from a child with microcephaly carrying compound heterozygous mutations of TYW1 inherited from healthy parents.
Chuanbo Sun +11 more
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Small SSEA-4-positive cells from human ovarian cell cultures: related to embryonic stem cells and germinal lineage? [PDF]
, 2013 Background: It has already been found that very small embyronic-like stem cells (VSELs) are present in adult human tissues and organs. The aim of this study was to find if there exists any similar population of cells in cell cultures of reproductive ...
Cvjeticanin, Branko +4 more
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Embryonic death and the creation of human embryonic stem cells [PDF]
Journal of Clinical Investigation, 2004 The creation of human embryonic stem cells through the destruction of a human embryo pits the value of a potential therapeutic tool against that of an early human life. This contest of values has resulted in a polarized debate that neglects areas of common interest and perspective.
Donald W, Landry, Howard A, Zucker
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A Combination of Culture Conditions and Gene Expression Analysis Can Be Used to Investigate and Predict hES Cell Differentiation Potential towards Male Gonadal Cells. [PDF]
PLoS ONE, 2015 Human embryonic stem cell differentiation towards various cell types belonging to ecto-, endo- and mesodermal cell lineages has been demonstrated, with high efficiency rates using standardized differentiation protocols. However, germ cell differentiation
Kristín Rós Kjartansdóttir +7 more
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First steps to define murine amniotic fluid stem cell microenvironment [PDF]
, 2016 Stem cell niche refers to the microenvironment where stem cells reside in living organisms. Several elements define the niche and regulate stem cell characteristics, such as stromal support cells, gap junctions, soluble factors, extracellular matrix ...
Bertin, Enrica +11 more
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Tenogenic Differentiation of Human Embryonic Stem Cells [PDF]
Tissue Engineering Part A, 2018 Tendon healing is complex to manage because of the limited regeneration capacity of tendon tissue; stem cell-based tissue engineering approaches may provide alternative healing strategies. We sought to determine whether human embryonic stem cells (hESC) could be induced to differentiate into tendon-like cells by the addition of exogenous bone ...
Dale T. P. +7 more
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