Results 91 to 100 of about 111,548 (274)
Recent Advances in Understanding the Reversal of Gene Silencing During X Chromosome Reactivation
Frontiers in Cell and Developmental Biology, 2019 Dosage compensation between XX female and XY male cells is achieved by a process known as X chromosome inactivation (XCI) in mammals. XCI is initiated early during development in female cells and is subsequently stably maintained in most somatic cells ...
Irene Talon +4 more
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Cells, 2022 Gap junctions (GJ) are suggested to support stem cell differentiation. The Muse cells that are applied in clinical trials are non-tumorigenic pluripotent-like endogenous stem cells, can be collected as stage-specific embryonic antigen 3 (SSEA-3 ...
Khaled Hatabi +6 more
doaj +1 more source
Functional cis-regulatory modules encoded by mouse-specific endogenous retrovirus [PDF]
, 2017 Cis-regulatory modules contain multiple transcription factor (TF)-binding sites and integrate the effects of each TF to control gene expression in specific cellular contexts.
Chen, Yujie +14 more
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Advanced Science, EarlyView.A flexible, ultrathin multi‐channel microelectrode array (MEA) conformally integrated onto a curved slide‐well enables stable electrical interfacing with 3D cardiac organoids. The geometry‐guided self‐alignment allows simultaneous recording of extracellular field potentials and contractile motion from irregular, beating tissues.
Ye Seul Kim +12 more
wiley +1 more source
The Unique Roles of Ion Channels in Pluripotent Stem Cells in Response to Biological Stimuli
BiologyIon channels are essential for mineral ion homeostasis in mammalian cells, and these are activated or inhibited by environmental stimuli such as heat, cold, mechanical, acidic, or basic stresses.
Taku Kaitsuka
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The Exciting Realities and Possibilities of iPS-Derived Cardiomyocytes
Bioengineering, 2023 Induced pluripotent stem cells (iPSCs) have become a prevalent topic after their discovery, advertised as an ethical alternative to embryonic stem cells (ESCs).
Fuga Takahashi +3 more
doaj +1 more source
Functional Crosstalk between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2 [PDF]
, 2015 Significance: Methylation of histone H3 on lysine 9 and 27 (H3K9 and H3K27) are two epigenetic modifications that have been linked to several crucial biological processes, among which are transcriptional silencing and cell differentiation.
Ait Si Ali, Slimane +2 more
core +2 more sources
Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis
Advanced Science, EarlyView.This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou +23 more
wiley +1 more source
Challenges and possible clinical applications of human embryonic stem cell research [PDF]
, 2012 Human embryonic stem cells (hESC) are harvested from the inner cell mass of the pre-implantation embryo and possess several unique characteristics. First, they are self-renewing, meaning they can grow indefinitely in an appropriate culture environment ...
De Sutter, Petra +3 more
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Pluripotency in the Embryo and in Culture [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 Specific cells within the early mammalian embryo have the capacity to generate all somatic lineages plus the germline. This property of pluripotency is confined to the epiblast, a transient tissue that persists for only a few days. In vitro, however, pluripotency can be maintained indefinitely through derivation of stem cell lines.
Jennifer, Nichols, Austin, Smith
openaire +2 more sources