Results 111 to 120 of about 111,548 (274)
An overview of mammalian pluripotency [PDF]
Development, 2016 ABSTRACT Mammalian pluripotency is the ability to give rise to all somatic cells as well as the germ cells of an adult mammal. It is a unique feature of embryonic epiblast cells, existing only transiently, as cells pass through early developmental stages.
Jun Wu +2 more
openaire +2 more sources
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types. [PDF]
, 2017 Large-scale collections of induced pluripotent stem cells (iPSCs) could serve as powerful model systems for examining how genetic variation affects biology and disease.
Adler, Eric +47 more
core +5 more sources
Molecular Systems Biology, 2013 Pluripotency in embryonic stem cells is maintained through the activity of a small set of transcription factors centred around Oct4 and Nanog, which control the expression of ‘self‐renewal’ and ‘differentiation’ genes.
Silvia Muñoz Descalzo +7 more
doaj +1 more source
Chaperones and Beyond as Key Players in Pluripotency Maintenance
Frontiers in Cell and Developmental Biology, 2019 Pluripotency is orchestrated by distinct players and chaperones and their partners have emerged as pivotal molecules in proteostasis control to maintain stemness.
Camila Felix de Lima Fernandes +4 more
doaj +1 more source
Gene Expression Profile Changes After Short-activating RNA-mediated Induction of Endogenous Pluripotency Factors in Human Mesenchymal Stem Cells [PDF]
, 2012 It is now recognized that small noncoding RNA sequences have the ability to mediate transcriptional activation of specific target genes in human cells.
Alluin, J +7 more
core +4 more sources
Defining Human Pluripotency [PDF]
Cell Stem Cell, 2019 Human pluripotent stem cells harbor the capacity to differentiate into cells from the three embryonic germ layers, and this ability grants them a central role in modeling human disorders and in the field of regenerative medicine. Here, we review pluripotency in human cells with respect to four different aspects: (1) embryonic development, (2 ...
Atilgan, Yilmaz, Nissim, Benvenisty
openaire +2 more sources
Temporal Interference Stimulation Enhances Neural Regeneration
Advanced Science, EarlyView.Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressotti +15 more
wiley +1 more source
Advanced Science, EarlyView.Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters +12 more
wiley +1 more source
Advanced Science, EarlyView.This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai +9 more
wiley +1 more source