Results 101 to 110 of about 83,579 (259)

Engineering a Bioelectronic Hybrid Heart with Integrated Sensing and Electrical Modulation

Advanced Science, EarlyView.
A bioelectronic hybrid heart is engineered by integrating iPSC‐derived cardiomyocytes, a decellularized cardiac scaffold, a cell‐laden ECM coating, and a flexible electronic mesh. The embedded electrodes enable real‐time recording of spontaneous electrical activity and localized stimulation, allowing controlled pacing and modulation of activation ...
Itai Cabilly, Hadas Oved, Ron Feiner, Nadav Noor, Moran Yadid, Melanie Flury, Assaf Shapira, Tal Dvir   +7 more
wiley   +1 more source

Pluripotency genes of mammals: a network at work [PDF]

Pluripotency, i.e., the ability to differentiate into cells of all three germ layers, is a transient state of early embryonic cells. In mammals, during progression from pre-implantation to post-implantation stage, pluripotent cells undergo different ...
Maddalena Mastrogiacomo, Ranieri Cancedda, R. Cancedda, M. Mastrogiacomo   +3 more
core   +1 more source

ViTAMIn‐O: Democratizing Computer Vision‐Based Machine Learning for Stem Cell Research

Advanced Intelligent Systems, EarlyView.
This study introduces a fully open generalist computer vision model for predicting the differentiation outcomes of stem cell‐based model systems, together with its code‐free deployment platform, ColabViTAMIn‐O. It is benchmarked against various architectures, datasets, and training protocols.
Ferhat Hamurcu, Markus Breunig, Arpad Varga, Bianka Bosch, Jessica Lindenmayer, Anjan T. Kanakappady, Kevin Achberger, Natalia Pashkovskaia, Alexander Kleger, Stefan Liebau, Stefanie Klingenstein, Moritz Klingenstein   +11 more
wiley   +1 more source

O-GlcNAc regulates pluripotency and reprogramming by directly acting on core components of the pluripotency network

, 2012
SummaryO-linked-N-acetylglucosamine (O-GlcNAc) has emerged as a critical regulator of diverse cellular processes, but its role in embryonic stem cells (ESCs) and pluripotency has not been investigated. Here we show that O-GlcNAcylation directly regulates
T W Kang, H Jang, S Yoon, Seon-Young Kim, H D Youn, E J Cho, Y W Kwon, S Y Choi, T W Kim   +8 more
core   +2 more sources

Differential regulation of OCT4 targets facilitates reacquisition of pluripotency [PDF]

, 2019
Ectopic transcription factor expression enables reprogramming of somatic cells to pluripotency, albeit with generally low efficiency. Despite steady progress in the field, the exact molecular mechanisms that coordinate this remarkable transition still ...
Thakurela, S., Smith, Z., Sindhu, C., Nachman, I., Yurkovsky, E., Riemenschneider, C. ; https://orcid.org/, Meissner, A. ; https://orcid.org/   +6 more
core   +1 more source

Engineering Intelligent iPSC Biomanufacturing: Integrating Robotic Automation, AI, and Process Control

Advanced Intelligent Systems, EarlyView.
This review highlights recent advances in automated iPSC culture systems integrating robotics, advanced imaging, artificial intelligence, and process control. These technologies improve reproducibility, scalability, and quality in cell expansion, differentiation, and real‐time monitoring, while emerging AI‐enabled and closed‐loop approaches offer new ...
Hyoryong Lee, Roma Desai, Byunggik Kim, Deok‐Ho Kim   +3 more
wiley   +1 more source

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Pluripotency of induced pluripotent stem cells

Journal of Animal Science and Biotechnology, 2012
Recent studies have demonstrated that differentiated somatic cells from various mammalian species can be reprogrammed into induced pluripotent stem (iPS) cells by the ectopic expression of four transcription factors that are highly expressed in embryonic
Kang Lan, Gao Shaorong
doaj   +1 more source

Pluripotency of wandering dynamics [PDF]

This paper proposes a new concept of pluripotency inspired by Colli-Vargas [Ergod. Theory Dyn. Syst., 21(6):1657-1681, 2001] and presents fundamental theorems for developing the theory.
Nakano, Yushi, Kiriki, Shin, Soma, Teruhiko   +2 more
core  

Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ES cell differentiation without affecting naïve to primed cell transition [PDF]

, 2014
The differentiation of mouse embryonic stem (ES) cells is controlled by the interaction of multiple signaling pathways, typically mediated by post-translational protein modifications.
Speakman, Christopher M., Stavridis, Marios P., Domke, Tanja C. E., Stavridis, Marios P. ; id_orcid, van Aalten, Daan M. F., Barton, Geoffrey J.; id_orcid, Sanders, Kelly, Wongpaiboonwattana, Wikrom, van Aalten, Daan M.F., Mudaliar, Manikhandan, Barton, Geoffrey J., Domke, Tanja C.E.   +11 more
core   +1 more source