Results 31 to 40 of about 62,870 (256)
NODAL Secures Pluripotency upon Embryonic Stem Cell Progression from the Ground State
Stem Cell Reports, 2017 Naive mouse embryonic stem cells (ESCs) can develop multiple fates, but the cellular and molecular processes that enable lineage competence are poorly characterized. Here, we investigated progression from the ESC ground state in defined culture.
Carla Mulas, Tüzer Kalkan, Austin Smith
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Construction of recombinant sox2-encoding plasmids that regulate pluripotency of breast cancer stem cells from indonesian patient [PDF]
Pharmaciana, 2019 A therapy development with recombinant protein is a new and potential innovation to destroy cancer stem cells (CSCs). Various ways of killing CSCs include the provision of polyvalent anti-protein antibodies that code pluripotency.
Hanifah Rahmi +3 more
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NANOG expression in parthenogenetic porcine blastocysts is required for intact lineage specification and pluripotency [PDF]
Animal Bioscience, 2023 Objective Nanog homeobox (NANOG) is a core transcription factor that contributes to pluripotency along with octamer binding transcription factor-4 (OCT4) and sex determining region-Y box-2 (SOX2).
Mingyun Lee +8 more
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Pluripotency in 3D: genome organization in pluripotent cells [PDF]
Current Opinion in Cell Biology, 2012 Cells face the challenge of storing two meters of DNA in the three-dimensional (3D) space of the nucleus that spans only a few microns. The nuclear organization that is required to overcome this challenge must allow for the accessibility of the gene regulatory machinery to the DNA and, in the case of embryonic stem cells (ESCs), for the transcriptional
Matthew, Denholtz, Kathrin, Plath
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Prospecting for pluripotency [PDF]
Nature Reviews Genetics, 2018 Unlike most organisms, planaria maintain pluripotent stem cells (PSCs) beyond embryogenesis. A new study reports the prospective identification and isolation of a neoblast subpopulation containing adult PSCs, characterization of which should help uncover the mechanisms underlying pluripotency and tissue regeneration.
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Statistical Mechanics of Pluripotency [PDF]
Cell, 2013 Recent reports using single-cell profiling have indicated a remarkably dynamic view of pluripotent stem cell identity. Here, we argue that the pluripotent state is not well defined at the single-cell level but rather is a statistical property of stem cell populations, amenable to analysis using the tools of statistical mechanics and information theory.
MacArthur, Ben D., Lemischka, Ihor R.
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Epigenetics of Pluripotent Cells [PDF]
Acta Naturae, 2012 Pluripotency is maintained by a complex system that includes the genetic and epigenetic levels. Recent studies have shown that the genetic level (transcription factors, signal pathways, and microRNAs) closely interacts with the enzymes and other specific proteins that participate in the formation of the chromatin structure.
Medvedev, S., Pokushalov, E., Zakian, S.
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microRNA-mediated regulation of microRNA machinery controls cell fate decisions
eLife, 2021 microRNAs associate with Argonaute proteins, forming the microRNA-induced silencing complex (miRISC), to repress target gene expression post-transcriptionally.
Qiuying Liu +4 more
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A pluripotent road to immunoengineering
Nature Reviews Bioengineering, 2023 Adoptive immunotherapy, particularly chimeric antigen receptor T cells, has achieved considerable success in treating hematologic malignancies over the past decade. However, variability, time commitment and high cost for engineering patient-derived cells have limited their application.
Yun Chang, Qing Deng, Xiaoping Bao
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Snapshots of Pluripotency [PDF]
Stem Cell Reports, 2016 Pluripotency is a unique developmental state that lays the foundation upon which the entire embryo is built. Pluripotent cells possess the unique capacity to generate, in an exquisitely defined sequence, all the distinct cell types comprising the fetal and adult organism. The discovery of pluripotent stem cells and now the ability to generate them from
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