Results 31 to 40 of about 83,579 (259)

A Genome-Wide CRISPR Screen Identifies Factors Regulating Pluripotency Exit in Mouse Embryonic Stem Cells

Cells, 2022
Pluripotency maintenance and exit in embryonic stem cells is a focal topic in stem cell biology. However, the effects of screening under very stringent culture conditions (e.g., differentiation medium, no leukemia inhibitory factor, no chemical ...
Chen Gao, Xiaolan Qi, Xin Gao, Jin Li, Yumin Qin, Yunjun Yin, Fei Gao, Tao Feng, Sen Wu, Xuguang Du   +9 more
doaj   +1 more source

SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program [PDF]

, 2018
The establishment and maintenance of pluripotency depend on precise coordination of gene expression. We establish serine-arginine-rich splicing factor 3 (SRSF3) as an essential regulator of RNAs encoding key components of the mouse pluripotency circuitry,
Dent, Craig I., De Los Mozos, Igor Ruiz, Beilharz, T.H., Jose M Polo, Anko, M-L, Madara Ratnadiwakara, Knaupp, AS, Ratnadiwakara, M, Dent, CI, Beilharz, Traude H., Polo, Jose M, Dent, Craig I, Archer, S.K., Polo, J.M., Ratnadiwakara, Madara, Polo, Jose M., Christian M Nefzger, Ruiz De Los Mozos, Igor, Nefzger, Christian M, Archer, SK, Ratnadiwakara, M., Knaupp, Anja S., Igor Ruiz De Los Mozos, De Los Mozos, I.R., Dent, C.I., De Los Mozos, IR, Stuart K Archer, Anko, Minna-Liisa, Anja S Knaupp, Knaupp, A.S., Archer, Stuart K, Anko, M.L., Polo, JM, Minna-Liisa Anko, Nefzger, CM, Knaupp, Anja S, Nefzger, Christian M., Nefzger, C.M., Traude H Beilharz, Archer, Stuart K., Craig I Dent, Beilharz, TH, Beilharz, Traude H; id_orcid   +42 more
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An Endogenously Tagged Fluorescent Fusion Protein Library in Mouse Embryonic Stem Cells

Stem Cell Reports, 2017
Embryonic stem cells (ESCs), with their dual capacity to self-renew and differentiate, are commonly used to study differentiation, epigenetic regulation, lineage choices, and more. Using non-directed retroviral integration of a YFP/Cherry exon into mouse
Arigela Harikumar, Raghu Ram Edupuganti, Matan Sorek, Gajendra Kumar Azad, Styliani Markoulaki, Petra Sehnalová, Soňa Legartová, Eva Bártová, Shlomit Farkash-Amar, Rudolf Jaenisch, Uri Alon, Eran Meshorer   +11 more
doaj   +1 more source

Super-enhancers conserved within placental mammals maintain stem cell pluripotency

, 2022
Despite pluripotent stem cells sharing key transcription factors, their maintenance involves distinct genetic inputs. Emerging evidence suggests that super-enhancers (SEs) can function as master regulatory hubs to control cell identity and pluripotency ...
Hua, Jinlian,, Shen, Qiaoyan,, Liao, Mingzhi, Li, Yunxiang, Zhou, Yaqi, Li, Yunxiang,, Lei, Anmin, Zhang, Juqing, Chen, Xingqi,, Hua, Jinlian, Yue, Wei,, Pan, Qin, Peng, Sha, Ding, Xinbao, Ding, Xinbao,, Li, Xinmei, Zhang, Rui, Liao, Mingzhi,, Yu, Shuai, Wu, Xiaolong,, Shen, Qiaoyan, Pan, Qin,, Yu, Shuai,, Li, Na,, Zhang, Rui,, Wu, Xiaolong, Warg, Wei, Zhou, Yaqi,, Li, Yayu,, Li, Yayu, Lei, Anmin,, Xu, Wenjing,, Wang, Yu, Zhang, Shiqiang, Zhang, Shiqiang,, Li, Na, Warg, Wei,, Yue, Wei, Xu, Wenjing, Zhang, Juqing,, Wu, Xiaojie,, Chen, Xingqi, Zhu, Zhenshuo,, Yang, Fan, Peng, Sha,, Li, Xinmei,, Wang, Yu,, Wu, Xiaojie, Zhu, Zhenshuo, Yang, Fan,   +49 more
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Promyelocytic Leukemia Protein Is an Essential Regulator of Stem Cell Pluripotency and Somatic Cell Reprogramming

Stem Cell Reports, 2017
Promyelocytic leukemia protein (PML), the main constituent of PML nuclear bodies, regulates various physiological processes in different cell types. However, little is known about its functions in embryonic stem cells (ESC).
Christiana Hadjimichael, Konstantina Chanoumidou, Christoforos Nikolaou, Antonios Klonizakis, Gesthimani-Ioanna Theodosi, Takis Makatounakis, Joseph Papamatheakis, Androniki Kretsovali   +7 more
doaj   +1 more source

The activation of the Sox2 RR2 pluripotency transcriptional reporter in human breast cancer cell lines is dynamic and labels cells with higher tumorigenic potential

Frontiers in Oncology, 2014
The striking similarity displayed at the mechanistic level between tumorigenesis and the generation of induced pluripotent stem cells and the fact that genes and pathways relevant for embryonic development are reactivated during tumor progression ...
Juan Manuel eIglesias, Juan Manuel eIglesias, Olatz eLeis Esnaola, Olatz eLeis Esnaola, Estibaliz ePerez Ruiz, Juan eGumuzio Barrie, Juan eGumuzio Barrie, Francisco eGarcia Garcia, Francisco eGarcia Garcia, Ariane eAduriz, Izaskun eBeloqui, Susana eHernandez Garcia, Maria Paz eLopez Mato, Joaquin eDopazo, Joaquin eDopazo, Joaquin eDopazo, Atanasio ePandiella, Javier eMenendez, Javier eMenendez, Angel eGarcia Martin, Angel eGarcia Martin   +20 more
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NaNog: A pluripotency homeobox (master) molecule. [PDF]

, 2015
One of the most intriguing aspects of cell biology is the state of pluripotency, where the cell is capable of self-renewal for as many times as deemed "necessary", then at a specified time can differentiate into any type of cell. This fundamental process
Aguib, YE, ElGuindy, AM, Allouba, MH, Krishnamoorthy, N, Yacoub, MH   +4 more
core   +1 more source

BCMA (TNFRSF17) Induces APRIL and BAFF Mediated Breast Cancer Cell Stemness

Frontiers in Oncology, 2018
Recent advances in cancer immunology revealed immune-related properties of cancer cells as novel promising therapeutic targets. The two TNF superfamily members, APRIL (TNFSF13), and BAFF (TNFSF13B), which are type II membrane proteins, released in active
Vasiliki Pelekanou, George Notas, Paraskevi Athanasouli, Konstantinos Alexakis, Fotini Kiagiadaki, Nikolaos Peroulis, Konstantina Kalyvianaki, Errika Kampouri, Hara Polioudaki, Panayiotis Theodoropoulos, Andreas Tsapis, Elias Castanas, Marilena Kampa   +12 more
doaj   +1 more source

Repressing Ago2 mRNA translation by Trim71 maintains pluripotency through inhibiting let-7 microRNAs

eLife, 2021
The regulation of stem cell fate is poorly understood. Genetic studies in Caenorhabditis elegans lead to the hypothesis that a conserved cytoplasmic double-negative feedback loop consisting of the RNA-binding protein Trim71 and the let-7 microRNA ...
Qiuying Liu, Xiaoli Chen, Mariah K Novak, Shaojie Zhang, Wenqian Hu   +4 more
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Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells

eLife, 2022
The transcription factor Oct4 is essential for the maintenance and induction of stem cell pluripotency, but its functional roles are not fully understood.
Le Xiong, Erik A Tolen, Jinmi Choi, Sergiy Velychko, Livia Caizzi, Taras Velychko, Kenjiro Adachi, Caitlin M MacCarthy, Michael Lidschreiber, Patrick Cramer, Hans R Schöler   +10 more
doaj   +1 more source