Results 21 to 30 of about 62,870 (256)
Modeling epigenetic modifications in renal development and disease with organoids and genome editing
Disease Models & Mechanisms, 2018 Understanding epigenetic mechanisms is crucial to our comprehension of gene regulation in development and disease. In the past decades, different studies have shown the role of epigenetic modifications and modifiers in renal disease, especially during ...
Carmen Hurtado del Pozo +3 more
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Genomics Data, 2015 Cardiomyocyte-like cells (CMs) derived from human pluripotent stem cells (hPSCs) present a valuable model for human disease modeling, studying early human development and, potentially, developing cell therapeutic approaches. However, the specification of
Ilaria Piccini +3 more
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Cell, 2008 In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES) cells in culture represent the ground state for a mammalian cell, signified by freedom from developmental specification or epigenetic restriction and capacity for autonomous self-replication.
Silva, Jose, Smith, Austin
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Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES
Nature Communications, 2018 The T-box transcription factor eomesodermin (EOMES) acts both in endoderm specification as well as heart development, suggesting context-specific function.
Martin J. Pfeiffer +7 more
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Revised roles of ISL1 in a hES cell-based model of human heart chamber specification
eLife, 2018 The transcription factor ISL1 is thought to be key for conveying the multipotent and proliferative properties of cardiac precursor cells. Here, we investigate its function upon cardiac induction of human embryonic stem cells.
Roberto Quaranta +8 more
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Cardiac Subtype-Specific Modeling of Kv1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells
Frontiers in Physiology, 2017 The ultrarapid delayed rectifier K+ current (IKur), mediated by Kv1.5 channels, constitutes a key component of the atrial action potential. Functional mutations in the underlying KCNA5 gene have been shown to cause hereditary forms of atrial fibrillation
Maike Marczenke +12 more
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The Battlefield of Pluripotency [PDF]
Cell, 2005 How embryonic stem cells maintain the potential to differentiate into multiple cell lineages is still unclear. In this issue of Cell, Niwa et al. (2005) show that a duel between the transcription factors Oct3/4 and Cdx2 can restrict embryonic stem cells to either embryonic or placental fate.
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Organization of the Pluripotent Genome [PDF]
Cold Spring Harbor Perspectives in Biology, 2020 In the past several decades, the establishment of in vitro models of pluripotency has ushered in a golden era for developmental and stem cell biology. Research in this arena has led to profound insights into the regulatory features that shape early embryonic development.
Lim, Patrick S.L., Meshorer, Eran
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Adrenergic Stress Protection of Human iPS Cell-Derived Cardiomyocytes by Fast Kv7.1 Recycling
Frontiers in Physiology, 2017 The fight-or-flight response (FFR), a physiological acute stress reaction, involves positive chronotropic and inotropic effects on heart muscle cells mediated through β-adrenoceptor activation.
Ilaria Piccini +8 more
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Recreating Pluripotency? [PDF]
Cell Stem Cell, 2010 Two Matters Arising articles in this issue challenge the conclusions of a previous Cell Stem Cell paper that found extensive transcriptional differences between hESCs and hiPSCs. The original authors provide a response and set in motion a discussion in the field about appropriate methods for microarray data analysis.
Loh, Kyle M., Lim, Bing
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