Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells [PDF]
, 2010 hESCs (human embryonic stem cells) offer great potential for pharmaceutical research and development and, potentially, for therapeutic use. However, improvements in cell culture are urgently required to allow the scalable production of large numbers of ...
Baillie, George S. +44 more
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Adrenergic Stress Protection of Human iPS Cell-Derived Cardiomyocytes by Fast Kv7.1 Recycling
Frontiers in Physiology, 2017 The fight-or-flight response (FFR), a physiological acute stress reaction, involves positive chronotropic and inotropic effects on heart muscle cells mediated through β-adrenoceptor activation.
Ilaria Piccini +8 more
doaj +1 more source
NODAL Secures Pluripotency upon Embryonic Stem Cell Progression from the Ground State
Stem Cell Reports, 2017 Naive mouse embryonic stem cells (ESCs) can develop multiple fates, but the cellular and molecular processes that enable lineage competence are poorly characterized. Here, we investigated progression from the ESC ground state in defined culture.
Carla Mulas, Tüzer Kalkan, Austin Smith
doaj +1 more source
Construction of recombinant sox2-encoding plasmids that regulate pluripotency of breast cancer stem cells from indonesian patient [PDF]
Pharmaciana, 2019 A therapy development with recombinant protein is a new and potential innovation to destroy cancer stem cells (CSCs). Various ways of killing CSCs include the provision of polyvalent anti-protein antibodies that code pluripotency.
Hanifah Rahmi +3 more
doaj +1 more source
NANOG expression in parthenogenetic porcine blastocysts is required for intact lineage specification and pluripotency [PDF]
Animal Bioscience, 2023 Objective Nanog homeobox (NANOG) is a core transcription factor that contributes to pluripotency along with octamer binding transcription factor-4 (OCT4) and sex determining region-Y box-2 (SOX2).
Mingyun Lee +8 more
doaj +1 more source
Recruitment of Oct4 protein to UV-damaged chromatin in embryonic stem cells. [PDF]
, 2011 BACKGROUND: Oct4 is a specific marker of embryonic stem cell (ESC) pluripotency. However, little is known regarding how Oct4 responds to DNA damage. Here, we investigated whether Oct4 recognizes damaged chromatin in mouse ESCs stably expressing GFP-Oct4.
Kozubek, Stanislav +17 more
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Control of pluripotency during the oocyte-to-embryo transition in caenorhabditis elegans [PDF]
, 2015 The germline of Caenorhabditis elegans has been used as a model system to study the control of pluripotency in germ cells: through the mean of a genetic screen, from which most of the results of this thesis derived, different factors involved in the ...
Tocchini, Cristina
core +1 more source
microRNA-mediated regulation of microRNA machinery controls cell fate decisions
eLife, 2021 microRNAs associate with Argonaute proteins, forming the microRNA-induced silencing complex (miRISC), to repress target gene expression post-transcriptionally.
Qiuying Liu +4 more
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Global DNA hypomethylation prevents consolidation of differentiation programs and allows reversion to the embryonic stem cell state. [PDF]
, 2012 DNA methylation patterns change dynamically during mammalian development and lineage specification, yet scarce information is available about how DNA methylation affects gene expression profiles upon differentiation.
Spada, Fabio +39 more
core +2 more sources
GENERATION OF MOUSE INDUCED PLURIPOTENT STEM CELLS BY PROTEIN TRANSDUCTION. [PDF]
, 2013 Somatic cell reprogramming has generated enormous interest after the first report by Yamanaka and his coworkers in 2006 on the generation of induced pluripotent stem cells (iPSCs) from mouse fibroblasts. Here we report the generation of stable iPSCs from
Polgár, Zsuzsanna +5 more
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