Results 11 to 20 of about 83,579 (259)

Chemical Screening Identifies Danofloxacin as a Self-Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1-Mediated Deacetylation of Tert and Prdm10. [PDF]

Adv Sci (Weinh)
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Zhang Y, Ji J, Dong B, Zhu Z, Lv X, Chen P, Liu W, Zhou M, Ye SD.   +8 more
europepmc   +2 more sources

ChristelKrueger/Exit-from-Pluripotency: v0.1

, 2023
Full Changelog: https://github.com/ChristelKrueger/Exit-from-Pluripotency/commits/v0.
Christel Krueger
core   +1 more source

CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes [PDF]

, 2014
Standard culture of human induced pluripotent stem cells (hiPSCs) requires basic Fibroblast Growth Factor (bFGF) to maintain the pluripotent state, whereas hiPSC more closely resemble epiblast stem cells than true naïve state ES which requires LIF to ...
Tang, D, Suzuki, H., Forrest, Alistair R. R., Hasegawa, Y., Suzuki, H, Ovchinnikov, Dmitry A., Hitchens, Kelly J., Takahashi, N., Forrest, A.R.R., Kenna, Tony, Suzuki, Harukazu, Tang, D., Joshi, Anagha, Hayashizaki, Y., Wolvetang, Ernst, Tang, Dave, Suzuki, H., Forrest, Alistair R R, FANTOM Consortium, the FANTOM consortium, Vijayan, Dipti, Wells, Christine A., Hasegawa, Y, Hayashizaki, Yoshihide, Forrest, ARR, Takahashi, Naoko, Briggs, James, Hasegawa, Yuki, Blumenthal, Antje, Tang, D., Hayashizaki, Y, ?, ?, Sajantila, Antti, Hasegawa, Y., Takahashi, N, Takahashi, N., Forrest, A. R., Beckhouse, Anthony G., FANTOM Consortium,, Hayashizaki, Y.   +39 more
core   +1 more source

NuRD Suppresses Pluripotency Gene Expression to Promote Transcriptional Heterogeneity and Lineage Commitment [PDF]

, 2012
Transcriptional heterogeneity within embryonic stem cell (ESC) populations has been suggested as a mechanism by which a seemingly homogeneous cell population can initiate differentiation into an array of different cell types.
O'Shaughnessy, Aoife, Bertone, Paul, Leaford, Donna, Brennecke, Philip, Kalkan, Tuezer, Costello, Ita, Nakagawa, Kentaro, Latos, Paulina, Hynes-Allen, Antony, Signolet, Jason, Reynolds, Nicola, Strouboulis, John, Behrens, Axel, Hendrich, Brian, Loos, Remco, Humphreys, Peter, Mansfield, William, Mosaku, Olukunbi   +17 more
core   +2 more sources

Modeling epigenetic modifications in renal development and disease with organoids and genome editing

Disease Models & Mechanisms, 2018
Understanding epigenetic mechanisms is crucial to our comprehension of gene regulation in development and disease. In the past decades, different studies have shown the role of epigenetic modifications and modifiers in renal disease, especially during ...
Carmen Hurtado del Pozo, Elena Garreta, Juan Carlos Izpisúa Belmonte, Nuria Montserrat   +3 more
doaj   +1 more source

A novel Nodal enhancer dependent on pluripotency factors and Smad2/3 signaling conditions a regulatory switch during epiblast maturation [PDF]

, 2014
During early development, modulations in the expression of Nodal, a TGFβ family member, determine the specification of embryonic and extra-embryonic cell identities.
Jérôme Collignon (34631), Francina Langa (49327), Jérôme Collignon, Ataaillah Benhaddou (588226), Ataaillah Benhaddou, Costis Papanayotou, Valérie Mezger (588227), Délara Sabéran-Djoneidi (588228), Collignon, Jérôme, Aitana Perea-Gomez, Délara Sabéran-Djoneidi, Aitana Perea-Gomez (34627), Anne Camus (246751), Perea-Gomez, Aitana, Jouneau, Alice, Camus, Anne, Langa, Francina, Benhaddou, Ataaillah, Francina Langa, Sascha Ott, Anne Camus, Sabéran-Djoneidi, Délara, Alice Jouneau, Papanayotou, Costis, Costis Papanayotou (83558), Sascha Ott (192042), Alice Jouneau (328085), Ott, Sascha, Mezger, Valérie, Valérie Mezger, Ott Sascha, Perea-Gomez Aitana, Collignon Jérôme, Langa Francina, Mezger Valérie, Sabéran-Djoneidi Délara, Benhaddou Ataaillah, Camus Anne, Papanayotou Costis, Jouneau Alice   +39 more
core   +1 more source

Human pluripotent stem cell-derived cardiomyocytes: Genome-wide expression profiling of long-term in vitro maturation in comparison to human heart tissue

Genomics Data, 2015
Cardiomyocyte-like cells (CMs) derived from human pluripotent stem cells (hPSCs) present a valuable model for human disease modeling, studying early human development and, potentially, developing cell therapeutic approaches. However, the specification of
Ilaria Piccini, Jyoti Rao, Guiscard Seebohm, Boris Greber   +3 more
doaj   +1 more source

Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES

Nature Communications, 2018
The T-box transcription factor eomesodermin (EOMES) acts both in endoderm specification as well as heart development, suggesting context-specific function.
Martin J. Pfeiffer, Roberto Quaranta, Ilaria Piccini, Jakob Fell, Jyoti Rao, Albrecht Röpke, Guiscard Seebohm, Boris Greber   +7 more
doaj   +1 more source

Revised roles of ISL1 in a hES cell-based model of human heart chamber specification

eLife, 2018
The transcription factor ISL1 is thought to be key for conveying the multipotent and proliferative properties of cardiac precursor cells. Here, we investigate its function upon cardiac induction of human embryonic stem cells.
Roberto Quaranta, Jakob Fell, Frank Rühle, Jyoti Rao, Ilaria Piccini, Marcos J Araúzo-Bravo, Arie O Verkerk, Monika Stoll, Boris Greber   +8 more
doaj   +1 more source

Cardiac Subtype-Specific Modeling of Kv1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells

Frontiers in Physiology, 2017
The ultrarapid delayed rectifier K+ current (IKur), mediated by Kv1.5 channels, constitutes a key component of the atrial action potential. Functional mutations in the underlying KCNA5 gene have been shown to cause hereditary forms of atrial fibrillation
Maike Marczenke, Maike Marczenke, Ilaria Piccini, Ilaria Piccini, Isabella Mengarelli, Jakob Fell, Jakob Fell, Albrecht Röpke, Guiscard Seebohm, Arie O. Verkerk, Arie O. Verkerk, Boris Greber, Boris Greber   +12 more
doaj   +1 more source