Results 11 to 20 of about 111,548 (274)
Frontiers in Cell and Developmental Biology, 2014 Vacanti and colleagues recently reported the generation of mouse cells exhibiting pluri/totipotency by stress treatment, and showed that these cells can give rise to chimeras and clonal adults (Obokata et al., 2014a,b). The findings were controversial, and the authors have now retracted the papers, citing multiple critical errors within the reports ...
Bor Luen eTang
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Assessing kidney development and disease using kidney organoids and CRISPR engineering
Frontiers in Cell and Developmental Biology, 2022 The differentiation of human pluripotent stem cells (hPSCs) towards organoids is one of the biggest scientific advances in regenerative medicine. Kidney organoids have not only laid the groundwork for various organ-like tissue systems but also provided ...
Wajima Safi +7 more
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Pluripotency of induced pluripotent stem cells [PDF]
Journal of Animal Science and Biotechnology, 2012 Recent studies have demonstrated that differentiated somatic cells from various mammalian species can be reprogrammed into induced pluripotent stem (iPS) cells by the ectopic expression of four transcription factors that are highly expressed in embryonic stem (ES) cells.
Kang Lan, Gao Shaorong
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Anaerobicizing into Pluripotency [PDF]
Cell Metabolism, 2011 Reprogramming involves multiple layers of molecular regulation, yet it remains relatively unknown how the cell's metabolism is changing and/or contributing to this process. In this issue of Cell Metabolism, Folmes et al. (2011) demonstrate that reprogramming induces a bioenergetic transition from an oxidative to a glycolytic state, and provide evidence
Panopoulos, Athanasia D. +1 more
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Harnessing mechanobiology for kidney organoid research
Frontiers in Cell and Developmental Biology, 2023 Recently, organoids have emerged as revolutionizing tools with the unprecedented potential to recreate organ-specific microanatomy in vitro. Upon their derivation from human pluripotent stem cells (hPSCs), organoids reveal the blueprints of human ...
Zarina Nauryzgaliyeva +5 more
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Pluripotency Deconstructed [PDF]
Development, Growth & Differentiation, 2018 Pluripotency denotes the flexible capacity of single cells to give rise to all somatic lineages and typically also the germline. Mouse ES cells and post‐implantation epiblast‐derived stem cells (EpiSC) are widely used pluripotent cell culture systems. These two in vitro stem cell types have divergent characteristics.
Kinoshita, Masaki, Smith, Austin
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Limited in vitro differentiation of porcine induced pluripotent stem cells into endothelial cells
Journal of Animal Reproduction and Biotechnology, 2023 Background: Pluripotent stem cells (PSCs) including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) offer the immense therapeutic potential in stem cell-based therapy of degenerative disorders.
In-Won Lee +8 more
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Hybridization led to a rewired pluripotency network in the allotetraploid Xenopus laevis
eLife, 2023 After fertilization, maternally contributed factors to the egg initiate the transition to pluripotency to give rise to embryonic stem cells, in large part by activating de novo transcription from the embryonic genome.
Wesley A Phelps +5 more
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Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation [PDF]
, 2020 Embryonic Stem Cell (ESC) differentiation requires complex cell signalling network dynamics, although the key molecular events remain poorly understood.
Budzyk, Manon +10 more
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Global DNA hypomethylation prevents consolidation of differentiation programs and allows reversion to the embryonic stem cell state. [PDF]
, 2012 DNA methylation patterns change dynamically during mammalian development and lineage specification, yet scarce information is available about how DNA methylation affects gene expression profiles upon differentiation.
Bultmann, Sebastian +9 more
core +11 more sources