Results 11 to 20 of about 62,870 (256)
Pluripotency of induced pluripotent stem cells [PDF]
Journal of Animal Science and Biotechnology, 2012 Recent studies have demonstrated that differentiated somatic cells from various mammalian species can be reprogrammed into induced pluripotent stem (iPS) cells by the ectopic expression of four transcription factors that are highly expressed in embryonic
Kang Lan, Gao Shaorong
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Frontiers in Cell and Developmental Biology, 2014 Vacanti and colleagues recently reported the generation of mouse cells exhibiting pluri/totipotency by stress treatment, and showed that these cells can give rise to chimeras and clonal adults (Obokata et al., 2014a,b). The findings were controversial, and the authors have now retracted the papers, citing multiple critical errors within the reports ...
Bor Luen eTang
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Anaerobicizing into Pluripotency [PDF]
Cell Metabolism, 2011 Reprogramming involves multiple layers of molecular regulation, yet it remains relatively unknown how the cell's metabolism is changing and/or contributing to this process. In this issue of Cell Metabolism, Folmes et al. (2011) demonstrate that reprogramming induces a bioenergetic transition from an oxidative to a glycolytic state, and provide evidence
Panopoulos, Athanasia D. +1 more
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Pluripotency Deconstructed [PDF]
Development, Growth & Differentiation, 2018 Pluripotency denotes the flexible capacity of single cells to give rise to all somatic lineages and typically also the germline. Mouse ES cells and post‐implantation epiblast‐derived stem cells (EpiSC) are widely used pluripotent cell culture systems. These two in vitro stem cell types have divergent characteristics.
Kinoshita, Masaki, Smith, Austin
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Speeding to Pluripotency [PDF]
Cell, 2014 Finding a cell that reprograms in a nonstochastic manner without genetic manipulation has proven elusive. In this issue, Guo et al. report the identification of a cell defined by an ultrafast cycle whose progeny reprogram in a synchronous and rapid manner.
Chenoweth, Josh G., McKay, Ronald D.
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Metamachines of pluripotent colloids [PDF]
Nature Communications, 2021 AbstractMachines enabled the Industrial Revolution and are central to modern technological progress: A machine’s parts transmit forces, motion, and energy to one another in a predetermined manner. Today’s engineering frontier, building artificial micromachines that emulate the biological machinery of living organisms, requires faithful assembly and ...
Antoine Aubret +2 more
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Proteomics and pluripotency [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2011 The fields of mass spectrometry (MS) and stem cell biology have expanded greatly in the past twenty years. Taken alone, these fields occupy entirely different branches of science; however, the points where they overlap provide valuable insight, both in the biological and technical arenas.
Justin, Brumbaugh +4 more
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Cell Research, 2013 Recent studies have uncovered a specific role of TET proteins in reprogramming somatic cells to induced pluripotent stem cells, a process where O-linked β-N-acetylglucosamine transferase may play a crucial role.
Ping, Wang +5 more
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Pluripotency of Induced Pluripotent Stem Cells
Genomics, Proteomics & Bioinformatics, 2013 Abstract Induced pluripotent stem (iPS) cells can be generated by forced expression of four pluripotency factors in somatic cells. This has received much attention in recent years since it may offer us a promising donor cell source for cell transplantation therapy. There has been great progress in iPS cell research in the past few years.
Chunjing Feng +2 more
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Cell Stem Cell, 2011 To date, pluripotent epiblast stem cells (EpiSCs) had only been derived from postimplantation mouse embryos. In this issue of Cell Stem Cell, Najm et al. (2011) demonstrate that EpiSCs can be routinely derived from preimplantation embryos, showing that both human and mouse blastocysts can produce the same class of primed pluripotent cells.
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