Results 21 to 30 of about 11,262 (208)
A NANOG‐pERK reciprocal regulatory circuit regulates Nanog autoregulation and ERK signaling dynamics [PDF]
The EMBO Reports, 2021 Abstract The self‐renewal and differentiation potential of embryonic stem cells (ESCs) is maintained by the regulated expression of core pluripotency factors. Expression levels of the core pluripotency factor Nanog are tightly regulated by a negative feedback autorepression ...
Hanuman T Kale +7 more
openaire +2 more sources
Nanog-like Regulates Endoderm Formation through the Mxtx2-Nodal Pathway [PDF]
, 2012 In mammalian embryonic stem cells, the acquisition of pluripotency is dependent on Nanog, but the in vivo analysis of Nanog has been hampered by its requirement for early mouse development. In an effort to examine the role of Nanog in vivo, we identified
Fan, Zi Peng +9 more
core +2 more sources
Nanog structure and simulation setup.
, 2023 (A) Human Nanog sequence. NTD, N-terminal domain; DBD, DNA-binding domain; CTD, C-terminal domain; WR, tryptophan-repeated region. The amino acid sequence in WR is depicted. (B) Charged resides in Nanog.
Cheng Tan (293674) +3 more
core +1 more source
Allocation of stem cell alterations in spermatogenesis of male rats affected by zymafluor and detection of reverse effect of vitamin E on testis histology using immunohistochemical techniques [PDF]
Scripta MedicaBackground/Aim: Zymafluor is a proven protective agent against dental caries and it is a naturally occurring agent present in water and soil. Aim of this study was to analyse the detrimental effect of sodium fluoride and opposing effect of vitamin E on ...
Noel Khalida I. +3 more
doaj +1 more source
Identification of Nanog as a novel inhibitor of Rad51 [PDF]
Cell Death & Disease, 2022 AbstractTo develop inhibitors targeting DNA damage repair pathways is important to improve the effectiveness of chemo- and radiotherapy for cancer patients. Rad51 mediates homologous recombination (HR) repair of DNA damages. It is widely overexpressed in human cancers and overwhelms chemo- and radiotherapy-generated DNA damages through enhancing HR ...
Ying Xin +12 more
openaire +3 more sources
On the Origin and Evolutionary History of NANOG
PLoS ONE, 2014 Though pluripotency is well characterized in mammals, many questions remain to be resolved regarding its evolutionary history. A necessary prerequisite for addressing this issue is to determine the phylogenetic distributions and orthology relationships of the transcription factor families sustaining or modulating this property.
Scerbo, Pierluigi +6 more
openaire +6 more sources
NANOG regulates the proliferation of PCSCs via the TGF-β1/SMAD pathway
Open Medicine, 2020 In prostate cancer, castration resistance is a factor that frequently leads to death in individuals with this disease. Recent studies have suggested that prostate cancer stem cells (PCSCs) are pivotal regulators in the establishment of castration ...
Liu Changming +7 more
doaj +1 more source
Radiology and Oncology, 2016 The data on expression and clinical impact of cancer stem cell markers SOX2, NANOG and OCT4 in lung cancer is still lacking. The aim of our study was to compare SOX2, NANOG and OCT4 mRNA expression levels in whole blood between advanced small-cell lung ...
Sodja Eva +5 more
doaj +1 more source
NANOG reporter cell lines generated by gene targeting in human embryonic stem cells. [PDF]
PLoS ONE, 2010 Pluripotency and self-renewal of human embryonic stem cells (hESCs) is mediated by a complex interplay between extra- and intracellular signaling pathways, which regulate the expression of pluripotency-specific transcription factors.
Yvonne Fischer +5 more
doaj +1 more source