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Single-cell RNA sequencing reveals that TAF7 promotes colorectal cancer stemness by targeting SOX2 [PDF]

Biology Direct
Background Cancer cell stemness plays a decisive role in tumor metastasis and recurrence. TATA-box binding protein-associated factor 7 (TAF7), which is highly expressed in multiple cancers and critical for metastasis, has not been clearly linked to ...
Xiaohui Ai, Yupei Jiang, Xiaoqing Huang, Haitao Ning, Shaojun Wang, Fang Li, Shulin Wu, Jun Mo   +7 more
doaj   +2 more sources

Neural stem cell self-renewal stimulation by store-operated calcium entries in adult mouse area postrema: influence of leptin

Frontiers in Cellular Neuroscience, 2023
Neural stem cells (NSCs) persist in specific brain germinative niches and sustain neurogenesis throughout life in adult mammals. In addition to the two major stem cell niches in the subventricular zone and the hippocampal dentate gyrus, the area postrema
Cyrine Ben Dhaou, Elodie Terrié, Nadine Déliot, Thomas Harnois, Laetitia Cousin, Patricia Arnault, Bruno Constantin, Emmanuel Moyse, Valérie Coronas   +8 more
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Human nasal olfactory stem cells, purified as advanced therapy medicinal products, improve neuronal differentiation

Frontiers in Neuroscience, 2022
BackgroundOlfactory ecto-mesenchymal stem cells (OE-MSC) are mesenchymal stem cells derived from the lamina propria of the nasal mucosa. They display neurogenic and immunomodulatory properties and were shown to induce recovery in animal models of spinal ...
Charlotte Jaloux, Charlotte Jaloux, Maxime Bonnet, Maxime Bonnet, Marie Vogtensperger, Marie Witters, Marie Witters, Julie Veran, Laurent Giraudo, Florence Sabatier, Florence Sabatier, Justin Michel, Regis Legré, Gaëlle Guiraudie-Capraz, François Féron, François Féron   +15 more
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Classification of lung adenocarcinoma based on stemness scores in bulk and single cell transcriptomes

Computational and Structural Biotechnology Journal, 2022
Tumor stemness is associated with tumor progression and therapy resistance. The recent advances in sequencing, genomics, and computational technologies have facilitated investigation into the tumor stemness cell-like characteristics.
Qian Liu, Jiali Lei, Xiaobo Zhang, Xiaosheng Wang   +3 more
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Betulinic Acid Inhibits the Stemness of Gastric Cancer Cells by Regulating the GRP78-TGF-β1 Signaling Pathway and Macrophage Polarization

Molecules, 2023
Cancer stemness is the process by which cancer cells acquire chemoresistance and self-renewal in the tumor microenvironment. Glucose-regulated protein 78 (GRP78) is a biomarker for gastric cancer and is involved in cancer stemness.
Jen-Lung Chen, Yun-Shen Tai, Hsin-Yi Tsai, Chia-Yuan Hsieh, Chun-Lin Chen, Chung-Jung Liu, Deng-Chyang Wu, Yaw-Bin Huang, Ming-Wei Lin   +8 more
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Integrative multi-omics analysis unveils stemness-associated molecular subtypes in prostate cancer and pan-cancer: prognostic and therapeutic significance

Journal of Translational Medicine, 2023
Background Prostate cancer (PCA) is the fifth leading cause of cancer-related deaths worldwide, with limited treatment options in the advanced stages. The immunosuppressive tumor microenvironment (TME) of PCA results in lower sensitivity to immunotherapy.
Kun Zheng, Youlong Hai, Yue Xi, Yukun Zhang, Zheqi Liu, Wantao Chen, Xiaoyong Hu, Xin Zou, Jie Hao   +8 more
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Stemness Subtypes and Scoring System Predict Prognosis and Efficacy of Immunotherapy in Soft Tissue Sarcoma

Frontiers in Immunology, 2022
Tumor stemness has been reported to play important roles in cancers. However, a comprehensive analysis of tumor stemness remains to be performed to investigate the specific mechanisms and practical values of stemness in soft tissue sarcomas (STS).
Hui-Yun Gu, Wen-Qiang Qu, Hai-Heng Peng, Yi-Feng Yu, Zhe-Zhen Jiang, Bai-Wen Qi, Ai-Xi Yu   +6 more
doaj   +1 more source

Low-density lipoprotein receptor promotes crosstalk between cell stemness and tumor immune microenvironment in breast cancer: a large data-based multi-omics study

Journal of Translational Medicine, 2023
Background Tumor cells with stemness in breast cancer might facilitate the immune microenvironment’s suppression process and led to anti-tumor immune effects.
Qihang Yuan, Xiaona Lu, Hui Guo, Jiaao Sun, Mengying Yang, Quentin Liu, Mengying Tong   +6 more
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A novel stemness classification in acute myeloid leukemia by the stemness index and the identification of cancer stem cell-related biomarkers

Frontiers in Immunology, 2023
BackgroundStem cells play an important role in acute myeloid leukemia (AML). However, their precise effect on AML tumorigenesis and progression remains unclear.MethodsThe present study aimed to characterize stem cell-related gene expression and identify ...
Yue Huang, Zhuo Zhang, Zhuo Zhang, Meijuan Sui, Yang Li, Yi Hu, Haiyu Zhang, Fan Zhang   +7 more
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High copy number variations, particular transcription factors, and low immunity contribute to the stemness of prostate cancer cells

Journal of Translational Medicine, 2021
Background Tumor metastasis is the main cause of death of cancer patients, and cancer stem cells (CSCs) is the basis of tumor metastasis. However, systematic analysis of the stemness of prostate cancer cells is still not abundant.
Zao Dai, Ping Liu
doaj   +1 more source