Results 31 to 40 of about 81,932 (265)

A Comprehensive Analysis of METTL1 to Immunity and Stemness in Pan-Cancer

Frontiers in Immunology, 2022
BackgroundPrevious studies have reported the effect of N7-methylguanosine (m7G) regulator methyltransferase like-1 protein (METTL1) in tumor initiation, metastasis, and chemosensitivity.
Zijie Gao, Zijie Gao, Jianye Xu, Jianye Xu, Zongpu Zhang, Zongpu Zhang, Yang Fan, Yang Fan, Hao Xue, Hao Xue, Xing Guo, Xing Guo, Lin Deng, Lin Deng, Shaobo Wang, Shaobo Wang, Rongrong Zhao, Rongrong Zhao, Ping Zhang, Ping Zhang, Gang Li, Gang Li   +21 more
doaj   +1 more source

Deconstructing stemness [PDF]

The EMBO Journal, 2005
Stem cells are unique in their capacity to self-renew and generate differentiated progeny to maintain tissues throughout life. A common molecular program for stem cells has remained elusive. We discuss what the molecular logic of stemness may be. We suggest that it may not be coupled to distinct cellular properties such as self-renewal or multipotency,
Harald, Mikkers, Jonas, Frisén
openaire   +2 more sources

Are Fertility Preservation Procedures Before Gonadotoxic Therapy and Hematopoietic Stem Cell Transplantation Feasible and Safe in Very Young Children? A Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian, Yannick Braun, Till‐Martin Theilen, Anke Barnbrock, Theresa Rohm, Fabienne Hammant, Nicole Sänger, Aynura Abbasova‐Semiz, Jan‐Henning Klusmann, Thomas Klingebiel, Udo Rolle, Peter Bader, Henning C. Fiegel, Andrea Jarisch   +13 more
wiley   +1 more source

Metabolic oxidoreductases: central regulators of the epigenetic landscapes in stemness

Experimental and Molecular Medicine
Cell metabolism has long been recognized as a fundamental process for energy production, biomolecule synthesis, and cell survival. During transitions between stem and somatic states, central carbon metabolism is rewired with concurrent changes in ...
Han-Teo Lee, Jae-Seok Roe, Hong-Duk Youn
doaj   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

IGFBPs were associated with stemness, inflammation, extracellular matrix remodeling and poor prognosis of low-grade glioma

Frontiers in Endocrinology, 2022
BackgroundThe IGFBP family of insulin-like growth factor binding proteins has important biological functions in the organism. However, the role of the IGFBP family in low-grade glioma (LGG) has not been fully explored.MethodsWe validated the clinical ...
Zhihui Liu, Zhihui Liu, Zhihui Liu, Hang Ji, Wenchao Fu, Wenchao Fu, Shuai Ma, Hongtao Zhao, Hongtao Zhao, Hongtao Zhao, Fang Wang, Fang Wang, Jiawei Dong, Jiawei Dong, Xiuwei Yan, Xiuwei Yan, Jiheng Zhang, Jiheng Zhang, Nan Wang, Nan Wang, Jiasheng Wu, Shaoshan Hu, Shaoshan Hu   +22 more
doaj   +1 more source

The Enhancement of Arabic Stemming by Using Light Stemming and Dictionary-Based Stemming

Journal of Software Engineering and Applications, 2011
Word stemming is one of the most important factors that affect the performance of many natural language processing applications such as part of speech tagging, syntactic parsing, machine translation system and information retrieval systems. Computational stemming is an urgent problem for Arabic Natural Language Processing, because Arabic is a highly ...
Yasir Alhanini, Mohd Juzaiddin Ab Aziz
openaire   +2 more sources

Improved Early Referral in Long‐Term Survivor Care With Institutional Standardized Practice Among Childhood Leukemia Survivors#

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In 2018, the Texas Children's Cancer and Hematology Center Leukemia Program implemented a practice standard to support the transition from treatment to survivorship that includes shared, alternating care between leukemia and survivorship clinicians and a reminder to refer survivors to the long‐term survivor clinic (LTSC) 2 years after ...
Ji Yun Tark, Kayla L. Foster, Omar Shakeel, Mary C. Shapiro, Shawki L. Qasim, ZoAnn Dreyer, Eric S. Schafer, Ashley M. Butler, Austin L. Brown, Maria Monica Gramatges   +9 more
wiley   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source