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Metronomic chemotherapy involves the administration of cytotoxic chemotherapy at reduced doses administered at regular and frequent intervals. Low-dose metronomic (LDM) chemotherapy represents an alternative to standard maximum tolerated dose (MTD ...
Wen-Ying Liao +2 more
doaj +1 more source
Cancer cells show heterogeneity in stemness, proliferation and EMT scores.
(A) Stemness, proliferation and EMT scores in single cells by cell type. Boxplots colors correspond to normal (blue), colorectal cancer (orange), and stem (red) cells.
Artem Baranovsky (12568587) +4 more
core +1 more source
STEM crisis or STEM surplus? Yes and yes [PDF]
The last decade has seen considerable concern regarding a shortage of science, technology, engineering, and mathematics (STEM) workers to meet the demands of the labor market. At the same time, many experts have presented evidence of a STEM worker surplus. A comprehensive literature review, in conjunction with employment statistics, newspaper articles,
Xue, Yi, Larson, Richard Charles
openaire +5 more sources
training dataset with known stemness information used to train this ...
Xiaohan Ren (9445418)
core +1 more source
E2F3 accelerates the stemness of colon cancer cells by activating the STAT3 pathway
IntroductionColon cancer is one of the most prevalent malignancies and causes of cancer-related deaths worldwide. Thus, further research is required to explicate the latent molecular mechanisms and look for novel biomarkers. E2F3 has been confirmed to be
Qingkun Gao +5 more
doaj +1 more source
Additional file 6. Figure S5. Stemness subtype chemotherapy sensitivity analysis and potential compound identification. (A) Box plot showing the sensitivity of chemotherapeutic agents between stemness subtypes, red indicates Stemness Subtype I, green ...
Ruihao Zhou (4987850) +7 more
core +1 more source
Coupling the modules of EMT and stemness: A tunable ‘stemness window’ model [PDF]
Metastasis of carcinoma involves migration of tumor cells to distant organs and initiate secondary tumors. Migration requires a complete or partial Epithelial-to-Mesenchymal Transition (EMT), and tumor-initiation requires cells possessing stemness ...
Pienta, Kenneth J. +6 more
core +1 more source
Thymosin β4 (Tβ4) is a small, 44-amino acid polypeptide. It has been implicated in multiple processes, including cell movement, angiogenesis, and stemness. Previously, we reported that melanoma cell lines differ in Tβ4 levels.
Aleksandra Makowiecka +7 more
doaj +1 more source
Cancer stem cells play crucial roles in colorectal cancer (CRC) tumorigenesis and treatment response. This study aimed to determine the value of the mRNA stemness index (mRNAsi) in CRC and introduce a stemness-related classification to predict the ...
Yi-Xin Yin (12337778) +5 more
core +1 more source
Hematopoietic stem cell metabolism and stemness
AbstractHematopoietic stem cells (HSCs) are considered to originate from the aorta-gonad-mesonephros, migrate into fetal liver for a rapid expansion, and eventually reside into a unique hypoxic bone marrow niche, where they maintain their homeostasis throughout their life span.
Dan Huang +4 more
openaire +3 more sources

