Results 11 to 20 of about 81,932 (265)
The role of microRNAs in stemness of cancer stem cells
Oncology Reviews, 2013 Cancer is one of the most important diseases of humans, for which no cure has been found so far. Understanding the causes of cancer can pave the way for its treatment. Alteration in genetic elements such as oncogenes and tumor suppressor genes results in
Seyed Mohammad Ali Hosseini Rad +5 more
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Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment [PDF]
Stem Cells International, 2017 Stemness combines the ability of a cell to perpetuate its lineage, to give rise to differentiated cells, and to interact with its environment to maintain a balance between quiescence, proliferation, and regeneration. While adult Stem Cells display these properties when participating in tissue homeostasis, Cancer Stem Cells (CSCs) behave as their ...
Pedro M. Aponte, Andrés Caicedo
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Stemming vision loss with stem cells [PDF]
Journal of Clinical Investigation, 2010 Dramatic advances in the field of stem cell research have raised the possibility of using these cells to treat a variety of diseases. The eye is an excellent target organ for such cell-based therapeutics due to its ready accessibility, the prevalence of vasculo- and neurodegenerative diseases affecting vision, and the availability of animal models to ...
Valentina, Marchetti +3 more
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Stemness, cancer, and cancer stem cells [PDF]
Cell Cycle, 2008 The ability of cancers to grow indefinitely has fueled the idea that cancer and stem cells may have common underlying mechanisms. Detailed gene expression maps have now shown the diversity and distinctiveness in gene expression programs associated with stemness in embryonic and adult stem cells. These maps have further revealed a shared transcriptional
David J, Wong +2 more
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Epitranscriptomics in the development, functions, and disorders of cancer stem cells
Frontiers in Oncology, 2023 Biomolecular modifications play an important role in the development of life, and previous studies have investigated the role of DNA and proteins. In the last decade, with the development of sequencing technology, the veil of epitranscriptomics has been ...
Linlin Hao +4 more
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Science, 2007 Two converging events took place on 9 August that ought to have the scientific community scratching its collective head. One of these is an anniversary: On that date in 2001, President George W. Bush signed an Executive Order banning any use of federal funds to support research on stem cells (save, of course, for those 78 preexisting cell lines, only ...
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T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications
Frontiers in Immunology, 2023 T cells play a crucial role in the regulation of immune response and are integral to the efficacy of cancer immunotherapy. Because immunotherapy has emerged as a promising treatment for cancer, increasing attention has been focused on the differentiation
Xiaoxia Chi +7 more
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BMC Cancer, 2023 Background Cancer stemness has been proven to affect tumorigenesis, metastasis, and drug resistance in various cancers, including lung squamous cell carcinoma (LUSC).
Jinzhi Lai +4 more
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To STEM or not to STEM? That is not the question
Cypriot Journal of Educational Sciences, 2018 The aim of this study is to identify the faults in Science, Technology, Engineering and Mathematics (STEM) education and to provide an approach to how these deficiencies can be eliminated. The STEM approach can provide students with an interdisciplinary point of view to gain creativity, critical thinking, high-level skills of thinking and problem ...
Kubat, U., Guray, E.
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Journal of Cancer Research and Practice, 2017 Metronomic chemotherapy involves the administration of cytotoxic chemotherapy at reduced doses administered at regular and frequent intervals. Low-dose metronomic (LDM) chemotherapy represents an alternative to standard maximum tolerated dose (MTD ...
Wen-Ying Liao +2 more
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