Results 51 to 60 of about 106,531 (314)

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

A Comprehensive Analysis of METTL1 to Immunity and Stemness in Pan-Cancer

Frontiers in Immunology, 2022
BackgroundPrevious studies have reported the effect of N7-methylguanosine (m7G) regulator methyltransferase like-1 protein (METTL1) in tumor initiation, metastasis, and chemosensitivity.
Zijie Gao, Zijie Gao, Jianye Xu, Jianye Xu, Zongpu Zhang, Zongpu Zhang, Yang Fan, Yang Fan, Hao Xue, Hao Xue, Xing Guo, Xing Guo, Lin Deng, Lin Deng, Shaobo Wang, Shaobo Wang, Rongrong Zhao, Rongrong Zhao, Ping Zhang, Ping Zhang, Gang Li, Gang Li   +21 more
doaj   +1 more source

Effect of fibronectin, FGF-2, and BMP4 in the stemness maintenance of BMSCs and the metabolic and proteomic cues involved

, 2021
Background: Growing evidence suggests that the pluripotent state of mesenchymal stem cells (MSCs) relies on specific local microenvironmental cues such as adhesion molecules and growth factors.
Carlton, Morgan, Chen, Xiaodan, Zhou, Yinghong, Chen, Lingling, Kaur, Navdeep, Parker, Tony J, Lin, Zhengmei, Xiao, Yin, Ryan, Hollie, Yinghong Zhou, Lingling Chen, Hollie Ryan, Navdeep Kaur, Xiaodan Chen, Morgan Carlton, Yin Xiao, Tony J Parker, Zhengmei Lin   +17 more
core   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Metabolic oxidoreductases: central regulators of the epigenetic landscapes in stemness

Experimental and Molecular Medicine
Cell metabolism has long been recognized as a fundamental process for energy production, biomolecule synthesis, and cell survival. During transitions between stem and somatic states, central carbon metabolism is rewired with concurrent changes in ...
Han-Teo Lee, Jae-Seok Roe, Hong-Duk Youn
doaj   +1 more source

DataSheet1_Novel Stemness-Related Gene Signature Predicting Prognosis and Indicating a Different Immune Microenvironment in HNSCC.docx

, 2022
Background: The head and neck squamous cell carcinomas (HNSCC) is one of the most frequent cancers in the world, with an unfavorable prognosis. Cancer stem cells (CSCs) have been found to be responsible for HNSCC recurrence and therapeutic resistance ...
Ben Ma (555388), Yu Wang (12152), Yi Luo (143206), Wei-Bo Xu (11635516)   +3 more
core   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

IGFBPs were associated with stemness, inflammation, extracellular matrix remodeling and poor prognosis of low-grade glioma

Frontiers in Endocrinology, 2022
BackgroundThe IGFBP family of insulin-like growth factor binding proteins has important biological functions in the organism. However, the role of the IGFBP family in low-grade glioma (LGG) has not been fully explored.MethodsWe validated the clinical ...
Zhihui Liu, Zhihui Liu, Zhihui Liu, Hang Ji, Wenchao Fu, Wenchao Fu, Shuai Ma, Hongtao Zhao, Hongtao Zhao, Hongtao Zhao, Fang Wang, Fang Wang, Jiawei Dong, Jiawei Dong, Xiuwei Yan, Xiuwei Yan, Jiheng Zhang, Jiheng Zhang, Nan Wang, Nan Wang, Jiasheng Wu, Shaoshan Hu, Shaoshan Hu   +22 more
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Deconstructing stemness [PDF]

The EMBO Journal, 2005
Stem cells are unique in their capacity to self-renew and generate differentiated progeny to maintain tissues throughout life. A common molecular program for stem cells has remained elusive. We discuss what the molecular logic of stemness may be. We suggest that it may not be coupled to distinct cellular properties such as self-renewal or multipotency,
Harald, Mikkers, Jonas, Frisén
openaire   +2 more sources