Results 31 to 40 of about 70,422 (295)

The prognostic value of whole blood SOX2, NANOG and OCT4 mRNA expression in advanced small-cell lung cancer

Radiology and Oncology, 2016
The data on expression and clinical impact of cancer stem cell markers SOX2, NANOG and OCT4 in lung cancer is still lacking. The aim of our study was to compare SOX2, NANOG and OCT4 mRNA expression levels in whole blood between advanced small-cell lung ...
Sodja Eva, Rijavec Matija, Koren Ana, Sadikov Aleksander, Korošec Peter, Cufer Tanja   +5 more
doaj   +1 more source

NANOG reporter cell lines generated by gene targeting in human embryonic stem cells. [PDF]

PLoS ONE, 2010
Pluripotency and self-renewal of human embryonic stem cells (hESCs) is mediated by a complex interplay between extra- and intracellular signaling pathways, which regulate the expression of pluripotency-specific transcription factors.
Yvonne Fischer, Elvira Ganic, Jacqueline Ameri, Xiaojie Xian, Martina Johannesson, Henrik Semb   +5 more
doaj   +1 more source

Reference loci for RT-qPCR analysis of differentiating human embryonic stem cells [PDF]

, 2013
Background: Selecting stably expressed reference genes is essential for proper reverse transcription quantitative polymerase chain reaction gene expression analysis. However, this choice is not always straightforward. In the case of differentiating human
De Sutter, Petra, Deforce, Dieter, Heindryckx, Björn, O'Leary, Thomas, Van Neste, Christophe, Vandesompele, Jo, Vossaert, Liesbeth   +6 more
core   +2 more sources

Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation [PDF]

, 2020
Embryonic Stem Cell (ESC) differentiation requires complex cell signalling network dynamics, although the key molecular events remain poorly understood.
Budzyk, Manon, Bustos, Francisco, Fernandez-Alonso, Rosalia, Findlay, Greg M., Helbig, Andreas O., Hukelmann, Jens, Kumar, Pankaj, Lamond, Angus I., Lanner, Fredrik, Petsalaki, Evangelia, Zhou, Houjiang   +10 more
core   +2 more sources

Nanog promotes stem-like traits of glioblastoma cells

Frontiers in Bioscience-Landmark, 2020
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with poor progrnosis and a high recurrence rate after surgery. To this end, we examined the role of Nanog that is highly expressed in this tumor. NANOG is a transcription factor involved in
Yuan Ye, Mengsi Zhang, Guangning Yan, Qinghua Ma, Zexuan Yan, ,Lihong Wang, Kaidi Yang, Deyu Guo   +7 more
doaj   +1 more source

MicroRNAs and Long Non-Coding RNAs as Regulators of NANOG Expression in the Development of Oral Squamous Cell Carcinoma

Frontiers in Oncology, 2021
NANOG is a stem cell transcription factor that is believed to play an important role in the development of oral squamous cell carcinoma (OSCC), but there is limited data regarding the role of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in the ...
Gašper Grubelnik, Emanuela Boštjančič, Aleksandar Aničin, Aleksandar Aničin, Tadej Dovšak, Tadej Dovšak, Nina Zidar   +6 more
doaj   +1 more source

Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency [PDF]

, 2017
Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells.
Adjaye, J, Campanella, M, De Coppi, P, Eaton, S, Faccenda, D, Guillot, P V, Hau, K-L, Hawkins, K E, Martin-Trujillo, A, Monk, D, Moschidou, D, Ranzoni, A M, Sanchez-Freire, V, Thrasher, A J, Tommasini, F, Wruck, W   +15 more
core   +4 more sources

Nanog regulates Pou3f1 expression at the exit from pluripotency during gastrulation

Biology Open, 2019
Pluripotency is regulated by a network of transcription factors that maintain early embryonic cells in an undifferentiated state while allowing them to proliferate.
Antonio Barral, Isabel Rollan, Hector Sanchez-Iranzo, Wajid Jawaid, Claudio Badia-Careaga, Sergio Menchero, Manuel J. Gomez, Carlos Torroja, Fatima Sanchez-Cabo, Berthold Göttgens, Miguel Manzanares, Julio Sainz de Aja   +11 more
doaj   +1 more source

Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal

iScience, 2023
Summary: The synergistic effect of alcohol and HCV mediated through TLR4 signaling transactivates NANOG, a pluripotency transcription factor important for the stemness of tumor-initiating stem-like cells (TICs).
Da-Wei Yeh, Cheng Liu, Juan Carlos Hernandez, Stanley M. Tahara, Hidekazu Tsukamoto, Keigo Machida   +5 more
doaj   +1 more source

Autophagy and mitophagy in hepatocarcinogenesis

Molecular & Cellular Oncology, 2018
Autophagy is required for benign hepatic tumors to progress into malignant hepatocellular carcinoma. In our recent studies, we found that autophagy, or more specifically mitophagy, was required to suppress TP53 and induce the expression of the ...
Kai Liu, Jiyoung Lee, Jing-Hsiung James Ou   +2 more
doaj   +1 more source