Results 31 to 40 of about 11,262 (208)

Nanog promotes stem-like traits of glioblastoma cells

Frontiers in Bioscience-Landmark, 2020
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with poor progrnosis and a high recurrence rate after surgery. To this end, we examined the role of Nanog that is highly expressed in this tumor. NANOG is a transcription factor involved in
Yuan Ye, Mengsi Zhang, Guangning Yan, Qinghua Ma, Zexuan Yan, ,Lihong Wang, Kaidi Yang, Deyu Guo   +7 more
doaj   +1 more source

MicroRNAs and Long Non-Coding RNAs as Regulators of NANOG Expression in the Development of Oral Squamous Cell Carcinoma

Frontiers in Oncology, 2021
NANOG is a stem cell transcription factor that is believed to play an important role in the development of oral squamous cell carcinoma (OSCC), but there is limited data regarding the role of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in the ...
Gašper Grubelnik, Emanuela Boštjančič, Aleksandar Aničin, Aleksandar Aničin, Tadej Dovšak, Tadej Dovšak, Nina Zidar   +6 more
doaj   +1 more source

Functional analysis of the Nanog tryptophan repeat [PDF]

, 2020
The homeodomain transcription factor NANOG promotes self-renewal of embryonic stem cells (ESCs) and specification of primordial germ cells (PGCs). NANOG binds thousands of sites within the ESC genome together with OCT4, SOX2 and RNA polymerase II (RNAPII)
Vojtek, Matúš
core   +1 more source

Nanog regulates Pou3f1 expression at the exit from pluripotency during gastrulation

Biology Open, 2019
Pluripotency is regulated by a network of transcription factors that maintain early embryonic cells in an undifferentiated state while allowing them to proliferate.
Antonio Barral, Isabel Rollan, Hector Sanchez-Iranzo, Wajid Jawaid, Claudio Badia-Careaga, Sergio Menchero, Manuel J. Gomez, Carlos Torroja, Fatima Sanchez-Cabo, Berthold Göttgens, Miguel Manzanares, Julio Sainz de Aja   +11 more
doaj   +1 more source

Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal

iScience, 2023
Summary: The synergistic effect of alcohol and HCV mediated through TLR4 signaling transactivates NANOG, a pluripotency transcription factor important for the stemness of tumor-initiating stem-like cells (TICs).
Da-Wei Yeh, Cheng Liu, Juan Carlos Hernandez, Stanley M. Tahara, Hidekazu Tsukamoto, Keigo Machida   +5 more
doaj   +1 more source

Autophagy and mitophagy in hepatocarcinogenesis

Molecular & Cellular Oncology, 2018
Autophagy is required for benign hepatic tumors to progress into malignant hepatocellular carcinoma. In our recent studies, we found that autophagy, or more specifically mitophagy, was required to suppress TP53 and induce the expression of the ...
Kai Liu, Jiyoung Lee, Jing-Hsiung James Ou   +2 more
doaj   +1 more source

Condensates containing Nanog and DNA fragments.

, 2023
(A–C) Results of a representative trajectory of 200 Nanog molecules and four DNA segments starting from a fully phase-separated configuration. (A) Time courses of 200 Nanog molecules (cyan) and four DNA (red) along the z-axis (long axis) of the slab. (B)
Cheng Tan (293674), Shoji Takada (282002), Yuji Sugita (140032), Azuki Mizutani (16641714)   +3 more
core   +1 more source

Targeting aggressive cancer stem cells in glioblastoma

Frontiers in Oncology, 2015
Glioblastoma (GBM) is the most common and fatal type of primary brain tumor. Gliosarcoma (GSM) is a rarer and more aggressive variant of GBM that has recently been considered a potentially different disease.
Tracy Christina Seymour, Anna eNowak, Foteini eKakulas   +2 more
doaj   +1 more source

Generation and characterization of a novel mouse embryonic stem cell line with a dynamic reporter of Nanog expression. [PDF]

PLoS ONE, 2013
The pluripotent state in embryonic stem (ES) cells is controlled by a core network of transcription factors that includes Nanog, Oct4 and Sox2. Nanog is required to reach pluripotency during somatic reprogramming and is the only core factor whose ...
Elsa Abranches, Evguenia Bekman, Domingos Henrique   +2 more
doaj   +1 more source

Exploring the NANOG-TET2 interaction interface. Effects of a selected mutation and hypothesis on the clinical correlation with anemias

Frontiers in Chemical Biology
In this study, we focused on the computational analysis of a selected single-point mutation identified by a NGS screening panel in the TET2 enzyme classified as “variant of uncertain clinical significance.” The mutation, namely Q1084P, occurs at the ...
Claudia Testi, Roberta Piacentini, Roberta Piacentini, Alessandro Perrone, Chiara Bartoli, Daniele Leso, Domitilla Pavia, Elisa Pistolesi, Flavio Scipione, Irene Cotronea, Marco Adinolfi Falcone, Marco Ierani, Alberto Boffi, Lorenzo Di Rienzo   +13 more
doaj   +1 more source