Results 1 to 10 of about 6,917 (104)
NANOG expression in parthenogenetic porcine blastocysts is required for intact lineage specification and pluripotency [PDF]
Animal Bioscience, 2023 Objective Nanog homeobox (NANOG) is a core transcription factor that contributes to pluripotency along with octamer binding transcription factor-4 (OCT4) and sex determining region-Y box-2 (SOX2).
Mingyun Lee +8 more
doaj +1 more source
Protodioscin protects porcine oocytes against H2O2-induced oxidative stress during in vitro maturation [PDF]
Animal Bioscience, 2023 Objective The present study investigated whether protodioscin (PD), a steroidal saponin mainly found in rhizome of Dioscorea species, alleviates oxidative stress-induced damage of porcine oocytes during in vitro maturation.
So-Hee Kim +8 more
doaj +1 more source
miR-27b antagonizes BMP signaling in early differentiation of human induced pluripotent stem cells
Scientific Reports, 2021 Human induced pluripotent stem (hiPS) cells are feasible materials for studying the biological mechanisms underlying human embryogenesis. In early embryogenesis, definitive endoderm and mesoderm are differentiated from their common precursor, mesendoderm.
Jaeeun Lim +3 more
doaj +1 more source
The Adipokine Visfatin Modulates Cancer Stem Cell Properties in Triple-Negative Breast Cancer
Biomedicines, 2023 Obesity is a cancer progression risk factor; excessive adipocytes increase adipokine secretion. Visfatin, a novel adipokine highly expressed in cancer patients, is related to breast cancer risk.
Yi-Fen Chiang +11 more
doaj +1 more source
MedComm, 2023 Esophageal squamous cell carcinoma (ESCC) is a frequently seen esophageal tumor type in China. Activation of signaling proteins and relevant molecular mechanisms in ESCC are partially explored, impairing the antitumor efficiency of targeted therapy in ...
Jie Chen +8 more
doaj +1 more source
Gli affects the stemness and prognosis of epithelial ovarian cancer via homeobox protein NANOG
Molecular Medicine Reports, 2020 Gli proteins are key transcription factors of the Hedgehog (HH) signaling pathway, which is associated with tumorigenesis and drug resistance. However, the role of the HH signaling pathway in epithelial ovarian cancer (EOC) remains unclear. Studies have demonstrated that in some tumors, homeobox protein NANOG (NANOG), a known stem cell marker, is a ...
Zhao, Huan +4 more
openaire +3 more sources
Journal of Experimental & Clinical Cancer Research, 2021 Background Temozolomide (TMZ) resistance limits its application in glioma. Exosome can carry circular RNAs (circRNAs) to regulate drug resistance via sponging microRNAs (miRNAs).
Chenyu Ding +13 more
doaj +1 more source
NANOG regulates the proliferation of PCSCs via the TGF-β1/SMAD pathway
Open Medicine, 2020 In prostate cancer, castration resistance is a factor that frequently leads to death in individuals with this disease. Recent studies have suggested that prostate cancer stem cells (PCSCs) are pivotal regulators in the establishment of castration ...
Liu Changming +7 more
doaj +1 more source
Identification and in vitro derivation of spermatogonia in beagle testis. [PDF]
PLoS ONE, 2014 BACKGROUND: In vitro culture of spermatogonial stem cells (SSCs) is important for exploration of SSCs self-renewal, differentiation, and manipulation. There are several reports on rodent SSC cultures; however, data on SSC cultures in domestic animals are
Kyung Hoon Lee +9 more
doaj +1 more source
PLoS ONE, 2021 Vitrification is an economically effective method for embryo cryopreservation in human and livestock animals; however, it carries the risk of damage by the exposure to severe oxidative stress.
Tarek A Alshaheen +2 more
doaj +1 more source