Results 11 to 20 of about 6,936 (122)

EN2 Regulates Pancreatic Cancer Initiation, Progression, and Epithelial-Mesenchymal Transition Through the Notch Signalling Pathway. [PDF]

J Cell Mol Med
ABSTRACT The incidence and mortality of pancreatic cancer are steadily increasing worldwide, and the disease is projected to become the second leading cause of cancer‐related deaths by 2030. Pancreatic tumorigenesis is driven by multiple genetic alterations, underscoring the need to elucidate the molecular mechanisms underlying pancreatic ...
Yu W, Varma RK, Ma Y, Boinpelly VC, Khatri A, Gombos E, Srivastava RK, Shankar S.   +7 more
europepmc   +2 more sources

A genomewide functional network for the laboratory mouse. [PDF]

PLoS Computational Biology, 2008
Establishing a functional network is invaluable to our understanding of gene function, pathways, and systems-level properties of an organism and can be a powerful resource in directing targeted experiments.
Yuanfang Guan, Chad L Myers, Rong Lu, Ihor R Lemischka, Carol J Bult, Olga G Troyanskaya   +5 more
doaj   +1 more source

Protein Arginine Methyltransferase 5 Is Necessary for Embryonic Development in Medaka Oryzias latipes

Fishes, 2022
Protein arginine methyltransferase 5 (Prmt5), conserved from yeast to humans, catalyzes arginine’s dimethylation in proteins. Prmt5 is necessary for embryonic development in mice because it maintains embryonic stem cells.
Xiaoting Liang, Shi Duan, Qing Yang, Xiaoqin Ma, Zhenyu Li, Qiting Yao, Kongyue Wu, Pei Chang, Gongqing Feng, Wentao Hong, Mengxi Cao, Qingchun Zhou, Xueping Zhong, Haobin Zhao   +13 more
doaj   +1 more source

THOC2 and THOC5 Regulate Stemness and Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, 2021
Triple‐negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. Radioresistance and stemness are substantial obstacles to TNBC treatment.
Xupeng Bai, Jie Ni, Julia Beretov, Shanping Wang, Xingli Dong, Peter Graham, Yong Li   +6 more
doaj   +1 more source

NANOG Is Multiply Phosphorylated and Directly Modified by ERK2 and CDK1 In Vitro

Stem Cell Reports, 2014
NANOG is a divergent homeobox protein and a core component of the transcriptional circuitry that sustains pluripotency and self-renewal. Although NANOG has been extensively studied on the transcriptional level, little is known regarding its ...
Justin Brumbaugh, Jason D. Russell, Pengzhi Yu, Michael S. Westphall, Joshua J. Coon, James A. Thomson   +5 more
doaj   +1 more source

Roles of Melatonin in Goat Hair Follicle Stem Cell Proliferation and Pluripotency Through Regulating the Wnt Signaling Pathway

Frontiers in Cell and Developmental Biology, 2021
Emerging studies show that melatonin promotes cashmere development through hypodermic implantation. However, the impact and underlying mechanisms are currently unknown.
Weidong Zhang, Niu Wang, Tongtong Zhang, Meng Wang, Wei Ge, Xin Wang   +5 more
doaj   +1 more source

Molecular characterization and expression patterns of Nanog gene validating its involvement in the embryonic development and maintenance of spermatogonial stem cells of farmed carp, Labeo rohita

Journal of Animal Science and Biotechnology, 2018
Background The homeobox containing transcription factor Nanog plays crucial roles in embryonic development/proliferation and/or maintenance of spermatogonial stem cells (SSCs) via interacting with transcription factors such as Oct4 and Sox2 in mammals ...
Swagat K. Patra, Chakrpani Vemulawada, Meenati M. Soren, Jitendra K. Sundaray, Manoj K. Panda, Hirak K. Barman   +5 more
doaj   +1 more source

Regulation of sarcomagenesis by the empty spiracles homeobox genes EMX1 and EMX2

Cell Death and Disease, 2021
The EMX (Empty Spiracles Homeobox) genes EMX1 and EMX2 are two homeodomain gene members of the EMX family of transcription factors involved in the regulation of various biological processes, such as cell proliferation, migration, and differentiation ...
Manuel Pedro Jimenez-García, Antonio Lucena-Cacace, Daniel Otero-Albiol, Amancio Carnero   +3 more
doaj   +1 more source

Transcription factor Six2 induces a stem cell‐like phenotype in renal cell carcinoma cells

FEBS Open Bio, 2019
Renal cell carcinoma (RCC) accounts for 2–3% of adult malignant tumors, and the incidence of RCC worldwide has increased by about 2% over the past two decades.
Na Cheng, Hongjuan Li, Yan Han, Shuzhen Sun   +3 more
doaj   +1 more source

CircRNA CDR1as/miR-641/HOXA9 pathway regulated stemness contributes to cisplatin resistance in non-small cell lung cancer (NSCLC)

Cancer Cell International, 2020
Background Cisplatin (DDP) is the first-line chemotherapeutic drug for non-small cell lung cancer (NSCLC), and long-term DDP stimulation increased resistance of NSCLC cells to this drug by enriching cancer stem cells (CSCs), which contributed to ...
Yongsheng Zhao, Renyan Zheng, Jian Chen, Dong Ning   +3 more
doaj   +1 more source