Results 41 to 50 of about 70,422 (295)

Systematic optimization of human pluripotent stem cells media using Design of Experiments. [PDF]

, 2015
Human pluripotent stem cells (hPSC) are used to study the early stages of human development in vitro and, increasingly due to somatic cell reprogramming, cellular and molecular mechanisms of disease.
Chailangkarn, Thanathom, Marinho, Paulo A, Muotri, Alysson R   +2 more
core   +1 more source

Sall4 Interacts with Nanog and Co-occupies Nanog Genomic Sites in Embryonic Stem Cells [PDF]

Journal of Biological Chemistry, 2006
Embryonic stem (ES) cells are pluripotent cells with self-renewing property. Nanog is a homeobox transcription factor required to maintain ES cells in a non-differentiated state. Using affinity purification coupled to liquid chromatography-tandem mass spectrometry analysis, we identified Sall4 as a Nanog co-purified protein.
Qiang, Wu, Xi, Chen, Jinqiu, Zhang, Yuin-Han, Loh, Teck-Yew, Low, Weiwei, Zhang, Wensheng, Zhang, Siu-Kwan, Sze, Bing, Lim, Huck-Hui, Ng   +9 more
openaire   +2 more sources

Targeting aggressive cancer stem cells in glioblastoma

Frontiers in Oncology, 2015
Glioblastoma (GBM) is the most common and fatal type of primary brain tumor. Gliosarcoma (GSM) is a rarer and more aggressive variant of GBM that has recently been considered a potentially different disease.
Tracy Christina Seymour, Anna eNowak, Foteini eKakulas   +2 more
doaj   +1 more source

Generation and characterization of a novel mouse embryonic stem cell line with a dynamic reporter of Nanog expression. [PDF]

PLoS ONE, 2013
The pluripotent state in embryonic stem (ES) cells is controlled by a core network of transcription factors that includes Nanog, Oct4 and Sox2. Nanog is required to reach pluripotency during somatic reprogramming and is the only core factor whose ...
Elsa Abranches, Evguenia Bekman, Domingos Henrique   +2 more
doaj   +1 more source

Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells [PDF]

, 2018
Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development.
Agnese Po, Andrea Carai, Angela Mastronuzzi, Elisabetta Ferretti, Elisabetta Ferretti, Enrico De Smaele, Evelina Miele, Felice Giangaspero, Felice Giangaspero, Franco Locatelli, Franco Locatelli, Luana Abballe, Marta Moretti, Zein Mersini Besharat   +13 more
core   +9 more sources

Esrrb Is a Direct Nanog Target Gene that Can Substitute for Nanog Function in Pluripotent Cells [PDF]

Cell Stem Cell, 2012
Embryonic stem cell (ESC) self-renewal efficiency is determined by the level of Nanog expression. However, the mechanisms by which Nanog functions remain unclear, and in particular, direct Nanog target genes are uncharacterized. Here we investigate ESCs expressing different Nanog levels and Nanog(-/-) cells with distinct functionally inducible Nanog ...
Festuccia, Nicola, Osorno, Rodrigo, Halbritter, Florian, Karwacki-Neisius, Violetta, Navarro, Pablo, Colby, Douglas, Wong, Frederick, Yates, Adam, Tomlinson, Simon R, Chambers, Ian   +9 more
openaire   +3 more sources

Distinct allelic patterns of nanog expression impart embryonic stem cell population heterogeneity. [PDF]

PLoS Computational Biology, 2013
Nanog is a principal pluripotency regulator exhibiting a disperse distribution within stem cell populations in vivo and in vitro. Increasing evidence points to a functional role of Nanog heterogeneity on stem cell fate decisions. Allelic control of Nanog
Jincheng Wu, Emmanuel S Tzanakakis
doaj   +1 more source

Endoglin Is Essential for the Maintenance of Self-Renewal and Chemoresistance in Renal Cancer Stem Cells. [PDF]

, 2017
Renal cell carcinoma (RCC) is a deadly malignancy due to its tendency to metastasize and resistance to chemotherapy. Stem-like tumor cells often confer these aggressive behaviors.
Dai, Jin, Guan, Wei, Hu, Junhui, Liu, Peijun, Qian, Yuan, Sharrow, Allison C, Tang, Kun, Wu, Lily, Xiao, Haibing, Xu, Hua, Ye, Zhangqun   +10 more
core   +3 more sources

Exploring the NANOG-TET2 interaction interface. Effects of a selected mutation and hypothesis on the clinical correlation with anemias

Frontiers in Chemical Biology
In this study, we focused on the computational analysis of a selected single-point mutation identified by a NGS screening panel in the TET2 enzyme classified as “variant of uncertain clinical significance.” The mutation, namely Q1084P, occurs at the ...
Claudia Testi, Roberta Piacentini, Roberta Piacentini, Alessandro Perrone, Chiara Bartoli, Daniele Leso, Domitilla Pavia, Elisa Pistolesi, Flavio Scipione, Irene Cotronea, Marco Adinolfi Falcone, Marco Ierani, Alberto Boffi, Lorenzo Di Rienzo   +13 more
doaj   +1 more source

First steps to define murine amniotic fluid stem cell microenvironment [PDF]

, 2016
Stem cell niche refers to the microenvironment where stem cells reside in living organisms. Several elements define the niche and regulate stem cell characteristics, such as stromal support cells, gap junctions, soluble factors, extracellular matrix ...
Bertin, Enrica, Bonaldo, Paolo, Braghetta, Paola, DE COPPI, Paolo, Dedja, Arben, Dona', Silvia, Franzin, Chiara, Piccoli, Martina, Pozzobon, Michela, Schiavi, Francesca, Spiro, Giovanna, Taschin, E.   +11 more
core   +3 more sources