Results 41 to 50 of about 11,262 (208)
Distinct allelic patterns of nanog expression impart embryonic stem cell population heterogeneity. [PDF]
PLoS Computational Biology, 2013 Nanog is a principal pluripotency regulator exhibiting a disperse distribution within stem cell populations in vivo and in vitro. Increasing evidence points to a functional role of Nanog heterogeneity on stem cell fate decisions. Allelic control of Nanog
Jincheng Wu, Emmanuel S Tzanakakis
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Sall4 Interacts with Nanog and Co-occupies Nanog Genomic Sites in Embryonic Stem Cells [PDF]
Journal of Biological Chemistry, 2006 Embryonic stem (ES) cells are pluripotent cells with self-renewing property. Nanog is a homeobox transcription factor required to maintain ES cells in a non-differentiated state. Using affinity purification coupled to liquid chromatography-tandem mass spectrometry analysis, we identified Sall4 as a Nanog co-purified protein.
Qiang, Wu +9 more
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, 2014 Human PPIN topological properties of 1TF (OCT4 or SOX2 or NANOG), 2TF (OCT4-SOX2 or OCT4-NANOG or SOX2-NANOG) and 3TF (OCT4-SOX2-NANOG) targets.
Liangcai Zhang (156659) +8 more
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Nanog Heterogeneity: Tilting at Windmills? [PDF]
Cell Stem Cell, 2013 Fluctuating expression of transcription factors in embryonic stem cells is an alluring observation, but, as outlined by two articles in this issue, appearances can be misleading.
openaire +2 more sources
miR-133a-3p and miR-145-5p co-promote goat hair follicle stem cell differentiation by regulating NANOG and SOX9 expression [PDF]
Animal BioscienceObjective Hair follicle stem cells (HFSCs) differentiation is a critical physiological progress in skin hair follicle (HF) formation. Goat HFSCs differentiation is one of the essential processes of superior-quality brush hair (SQBH) synthesis.
Jian Wang +6 more
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Prediction of the effect of single allele deletion on Nanog expression.
, 2013 Nanog expression distribution in (A) Nanog+/+ and (B) Nanog+/− mESCs. The fractions of NANOG-positive and -negative cells are also shown. (C) Average NANOG expression level of Nanog+/+ and Nanog+/− cell populations calculated from the distributions in (A)
Emmanuel S. Tzanakakis (114570) +1 more
core +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Frontiers in Cell and Developmental BiologyIntroductionThe safe and effective application of human pluripotent stem cells (hPSCs) in research and regenerative medicine requires precise control over pluripotency and cell fate.
Petr Fojtík +23 more
doaj +1 more source
Frontiers in Oncology, 2021 BackgroundCancer stem cells (CSCs) and Circulating tumor cells (CTCs) have been proposed as fundamental causes for the recurrence of hepatocellular carcinoma (HCC).
Yongrong Lei +7 more
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Esrrb is a prominent target of Nanog that substitutes for Nanog function in ES cell self-renewal, reprogramming and germline development [PDF]
, 2013 Embryonic stem (ES) cell pluripotency is sustained by a network of transcription factors centred on Oct4, Sox2 and Nanog. Whilst Oct4 and Sox2 expression is relatively uniform, ES cells fluctuate between states of high Nanog expression possessing high
Festuccia, Nicola
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