Results 61 to 70 of about 11,262 (208)
Advanced Science, EarlyView.Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li +8 more
wiley +1 more source
Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the role of High-mobility group box-1 (HMGB1) protein in regulating the expression of cancer stem cell markers Nanog, OCT4 and Sox2.
WANG Hua +4 more
doaj +1 more source
Analysis of topological properties of NANOG-miRNA-targets in mouse PPIN.
, 2014 (A) Comparison of NANOG-miRNA and NANOG-non-miRNA targets. (B) Comparison of NANOG-miRNA and non-NANOG-non-miRNA targets.
Liangcai Zhang (156659) +8 more
core +1 more source
, 2023 NANOG, a stemness-associated transcription factor, is highly expressed in many cancers and plays a critical role in regulating tumorigenicity. Transformation/transcription domain-associated protein (TRRAP) has been reported to stimulate the tumorigenic ...
Dong-Soo Suh +11 more
core +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Advanced Science, EarlyView.Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen +7 more
wiley +1 more source
, 2016 1) Distributions of the sampled trajectories using STILT on the Nanog subtree dataset 2) Goodness-of-fit test distributions Related to : Analysis of cell lineage trees by exact Bayesian inference identifies negative autoregulation of Nanog in mouse ...
Feigelman, J (via Mendeley Data) +2 more
core +3 more sources
Epigenetics & Chromatin, 2020 Transcriptional repression of Nanog is an important hallmark of stem cell differentiation. Chromatin modifications have been linked to the epigenetic profile of the Nanog gene, but whether chromatin organization actually plays a causal role in Nanog ...
Francisco J. González-Rico +8 more
doaj +1 more source
A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis. [PDF]
PLoS ONE, 2010 NANOG is a key player in pluripotency and its expression is restricted to pluripotent cells of the inner cell mass, the epiblast and to primordial germ cells.
Ewart W Kuijk +6 more
doaj +1 more source
Advanced Science, EarlyView.In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang +18 more
wiley +1 more source