Results 71 to 80 of about 11,262 (208)
Expression of the stem cell markers NANOG and SOX2 in the cervical squamous carcinogenesis
Radiology and OncologyThe aim of the present study was to assess a diagnostic potential of stem cell markers NANOG and SOX2 for classifying cervical squamous intraepithelial lesions (SILs)/cervical intraepithelial neoplasia (CIN).
Koren Miha +4 more
doaj +1 more source
Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis. [PDF]
PLoS ONE, 2010 The expression of the transcription factors Oct4, Sox2, and Nanog is commonly associated with pluripotency of mouse embryonic stem (ES) cells. However, recent observations suggest that ES cell populations are heterogeneous with respect to the expression ...
Ingmar Glauche +2 more
doaj +1 more source
Nanog Regulates Primordial Germ Cell Migration Through Cxcr4b
, 2010 Gonadal development in vertebrates depends on the early determination of primordial germ cells (PGCs) and their correct migration to the sites where the gonads develop. Several genes have been implicated in PGC specification and migration in vertebrates.
Manuel Díaz-Llopis +6 more
core +1 more source
Advanced Science, EarlyView.A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung +15 more
wiley +1 more source
ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal
Stem Cell Research, 2014 Nanog regulates human and mouse embryonic stem (ES) cell self-renewal activity. Activation of ERKs signaling negatively regulates ES cell self-renewal and induces differentiation, but the mechanisms are not understood.
Sung-Hyun Kim +14 more
doaj +1 more source
Transcriptional Regulation of Nanog by OCT4 and SOX2 [PDF]
Journal of Biological Chemistry, 2005 Nanog, Sox2, and Oct4 are transcription factors all essential to maintaining the pluripotent embryonic stem cell phenotype. Through a cooperative interaction, Sox2 and Oct4 have previously been described to drive pluripotent-specific expression of a number of genes. We now extend the list of Sox2-Oct4 target genes to include Nanog.
Rodda, D.J. +6 more
openaire +2 more sources
Advanced Science, EarlyView.Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao +15 more
wiley +1 more source
Context-Dependent Functions of NANOG Phosphorylation in Pluripotency and Reprogramming
Stem Cell Reports, 2017 The core pluripotency transcription factor NANOG is critical for embryonic stem cell (ESC) self-renewal and somatic cell reprogramming. Although NANOG is phosphorylated at multiple residues, the role of NANOG phosphorylation in ESC self-renewal is ...
Arven Saunders +10 more
doaj +1 more source
Advanced Science, EarlyView.Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin +7 more
wiley +1 more source
Molecular Characterization of the Human NANOG Protein [PDF]
Stem Cells, 2009 Abstract NANOG is a key transcriptional regulator of pluripotent stem cell (PSC) self-renewal. NANOG occupies promoters that are active and others that are repressed during self-renewal; however, the mechanisms by which NANOG regulates transcriptional repression and activation are unknown.
David F, Chang +5 more
openaire +2 more sources